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Echinococcus multilocularis: mouse strain difference in hydatid development

Published online by Cambridge University Press:  05 June 2009

K. Nakaya ,
M. Nakao  and
A. Ito
K. Nakaya
Affiliation:
Animal Laboratory for Medical Research, Asahikawa Medical College, Asahikawa 078, Japan
M. Nakao
Affiliation:
Department of Parasitology, Asahikawa Medical College, Asahikawa 078, Japan
A. Ito
Affiliation:
Department of Parasitology, Gifu University School of Medicine, Gifu 500, Japan
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Abstract

Female mice of nine inbred strains (A, AKR, BALB/c, C3H, C57BL/6, C57BL/10, CBA, DBA/1 and DBA/2) and H-2 congenic B10.D2, at 9–10 weeks of age, were infected with larval Echinococcus multilocularis by trans-portal injection of hydatid homogenate. Parasitized livers were histologically examined 9 or 13 weeks after infection. Hydatid development was quite different among mouse strains. Multivesiculation was prominent in C57BL/10, DBA/1, C57BL/6 and BALB/c. Protoscoleces were well developed in DBA/2, AKR, DBA/1 and CBA. H-2 congenic B10.D2, which has the background genes of C57BL/10 except for the H-2d gene of DBA/2, resembled C57BL/10 in prohibiting the development of protoscoleces. These data suggest that the qualitative difference in hydatid development may be regulated by non-H-2 gene(s).

Type
Research Papers
Information
Journal of Helminthology , Volume 71 , Issue 1 , March 1997 , pp. 53 - 56
Copyright
Copyright © Cambridge University Press 1997

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