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Diet-induced modulation of pharmacokinetics of albendazole in Sahiwal cattle

Published online by Cambridge University Press:  26 August 2015

P.K. Sanyal ,
D. Rawte ,
A.E. Kerketta ,
N.K. Kumbhakar ,
D. Kumar ,
S. Pal ,
K.R. Baghel  and
S. Bisen
P.K. Sanyal*
Affiliation:
Department of Veterinary Parasitology, College of Veterinary Science & Animal Husbandry, Chhattisgarh Kamdhenu Vishwavidyalaya, Anjora, durg-491 001, Chhattisgarh, India
D. Rawte
Affiliation:
Department of Veterinary Parasitology, College of Veterinary Science & Animal Husbandry, Chhattisgarh Kamdhenu Vishwavidyalaya, Anjora, durg-491 001, Chhattisgarh, India
A.E. Kerketta
Affiliation:
Department of Veterinary Parasitology, College of Veterinary Science & Animal Husbandry, Chhattisgarh Kamdhenu Vishwavidyalaya, Anjora, durg-491 001, Chhattisgarh, India
N.K. Kumbhakar
Affiliation:
Department of Veterinary Parasitology, College of Veterinary Science & Animal Husbandry, Chhattisgarh Kamdhenu Vishwavidyalaya, Anjora, durg-491 001, Chhattisgarh, India
D. Kumar
Affiliation:
Department of Veterinary Parasitology, College of Veterinary Science & Animal Husbandry, Chhattisgarh Kamdhenu Vishwavidyalaya, Anjora, durg-491 001, Chhattisgarh, India
S. Pal
Affiliation:
Department of Veterinary Parasitology, College of Veterinary Science & Animal Husbandry, Chhattisgarh Kamdhenu Vishwavidyalaya, Anjora, durg-491 001, Chhattisgarh, India
K.R. Baghel
Affiliation:
Department of Veterinary Parasitology, College of Veterinary Science & Animal Husbandry, Chhattisgarh Kamdhenu Vishwavidyalaya, Anjora, durg-491 001, Chhattisgarh, India
S. Bisen
Affiliation:
Department of Veterinary Parasitology, College of Veterinary Science & Animal Husbandry, Chhattisgarh Kamdhenu Vishwavidyalaya, Anjora, durg-491 001, Chhattisgarh, India
*
*Fax: 91-788-2252139 E-mail: sanyalprabir54@googlemail.com
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Abstract

The influence of diet type and pre-treatment fasting on the kinetic disposition of albendazole was evaluated in Sahiwal heifers following oral and intra-ruminal administration of the drug. The anthelmintically active moiety albendazole sulphoxide appeared early and was eliminated early in cattle offered green fodder, with decreased maximum concentration (Cmax) and area under concentration–time curve (AUC) when the drug was administered both through oral and intra-ruminal routes. Further, the elimination half-life (t½β) revealed significantly increased values for albendazole sulphoxide in cattle administered albendazole through the intra-ruminal route. An increased AUC and t½β is reflective of increased bioavailability of albendazole in animals offered dry fodder. Increased values (P <  0.05) of Cmax, time to Cmax (Tmax), AUC and t½β for albendazole sulphoxide occurred in cattle with a pre-treatment 24-h fast, resulting in its increased bioavailability. Extrapolation of data of the active metabolite albendazole sulphoxide levels in terms of drug–parasite contact revealed increased exposure of parasites to the drug in cattle administered albendazole through the intra-ruminal route and with 24-h pre-treatment fasting.

Type
Research Papers
Information
Journal of Helminthology , Volume 90 , Issue 5 , September 2016 , pp. 555 - 560
Copyright
Copyright © Cambridge University Press 2015 

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References

Ali, D.N. & Hennessy, D.R. (1995) The effect of level of feed intake on the pharmacokinetic disposition of oxfendazole in sheep. International Journal for Parasitology 25, 63–70.Google Scholar
Alwash, A.H. & Thomas, P.C. (1971) The effect of the physical form of the diet and level of feeding on the digestion of dried grass by sheep. Journal of the Science of Food and Agriculture 22, 611–615.Google Scholar
Arundel, J.H. (1983) Anthelmintics for sheep. pp. 19–50 in Proceedings No. 67, Sheep production and preventive medicine. The Post-graduate Committee in Veterinary Science, University of Sydney.Google Scholar
Bogan, J.A. & Marriner, S.E. (1987) The rumen as a pharmacokinetic compartment. pp. 253–270 in Ooms, I.A.A., Degryse, A.D. & Van Miert, A.S.J.P.A.M. (Eds) Physiological and pharmacological aspects of reticulo-rumen. Dordrecht, Martinus Nijhoff.Google Scholar
Hennessy, D.R. (1993) Pharmacokinetic disposition of benzimidazole drugs in ruminant gastrointestinal tract. Parasitology Today 9, 329–333.Google Scholar
Hennessy, D.R. (1994) The disposition of antiparasitic drugs in relation to the development of resistance by parasites of livestock. Acta Tropica 56, 125–141.Google Scholar
Hennessy, D.R. (1997) Physiology, pharmacology and parasitology. International Journal for Parasitology 27, 145–152.CrossRefGoogle ScholarPubMed
Hennessy, D.R., Lacey, E., Prichard, R.K. & Steel, J.W. (1985) Potentiation of the anthelmintic activity of oxfendazole by parbendazole. Journal of Veterinary Pharmacology and Therapeutics 8, 270–275.Google Scholar
Lanusse, C., Sanchez, S. & Alvarez, L. (1994) Influence of fasting and nutritional status on the kinetics of albendazole in cattle. pp. 249 in Lees, P. (Ed.) Proceedings of the 6th International Congress, European Association of Veterinary Pharmacology and Toxicology, Edinburgh. Abstract No. S1003. Edinburgh, Blackwell Scientific.Google Scholar
Prichard, R.K., Hennessy, D.R. & Steel, J.W. (1978) Prolonged administration: a new concept for increasing spectrum and effectiveness of anthelmintics. Veterinary Parasitology 4, 309–315.Google Scholar
Sanyal, P.K. (1994) Pharmacokinetic behaviour of fenbendazole in buffalo and cattle. Journal of Veterinary Pharmacology and Therapeutics 17, 1–4.Google Scholar
Sanyal, P.K. (1997) Disposition kinetics of albendazole in buffalo and cattle. Journal of Veterinary Pharmacology and Therapeutics 20, 240–242.CrossRefGoogle ScholarPubMed
Sanyal, P.K., Knox, M.R., Singh, D.K., Hennessy, D.R. & Steel, J.W. (1995) Influence of diet type on the kinetic disposition of fenbendazole in cattle and buffalo. International Journal for Parasitology 25, 1201–1205.Google Scholar
Sanyal, P.K., Rawte, D., Kerketta, A.E., Pal, S., Baghel, K.R. & Bisen, S. (2015) Emergence of anthelmintic resistance in ruminants in Chhattisgarh. Journal of Veterinary Parasitology, in press.Google Scholar
Singh, D., Sanyal, P.K., Swarnkar, C.P., Khan, F.A. & Bhagwan, P.S.K. (1999) Influence of diet type and pretreatment fasting on the disposition kinetics of albendazole in sheep. Veterinary Research Communications 23, 229–240.CrossRefGoogle ScholarPubMed
Swarnkar, C.P., Sanyal, P.K., Singh, D., Khan, F.A. & Bhagwan, P.S.K. (1998) Comparative disposition kinetics of albendazole in sheep following oral and intraruminal administration. Veterinary Research Communications 22, 545–551.Google Scholar
Warner, A.C.I. (1981) Rate of passage of digesta through the gut of mammals and birds. Nutrition Abstracts and Reviews, Series B 51, 789–820.Google Scholar