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Chemoprophylactic studies with ivermectin against subperiodic Brugia malayi infection in the leaf monkey, Presbytis cristata

Published online by Cambridge University Press:  05 June 2009

J. W. Mak
Affiliation:
Institute for Medical Research, Jalan Pahang, 50588 Kuala Lumpur, Malaysia
P. L. W. Lam
Affiliation:
Institute for Medical Research, Jalan Pahang, 50588 Kuala Lumpur, Malaysia
A. Noor Rain
Affiliation:
Institute for Medical Research, Jalan Pahang, 50588 Kuala Lumpur, Malaysia
K. Suresh
Affiliation:
Institute for Medical Research, Jalan Pahang, 50588 Kuala Lumpur, Malaysia

Abstract

Four Presbytis cristata were treated with oral ivermectin at the same time as the subcutaneous inoculation of 100 infective larvae monthly for three months. Two animals given 0·2 mg/kg monthly and two others given 0·3 mg/kg monthly as well as three control animals became patent for microfilaraemia. However, only 1% of the infective dose was recovered as adult worms from animals in the higher drug dosage group compared to 8·2% and 6·2% in the lower dosage and control groups respectively.

Type
Research Papers
Copyright
Copyright © Cambridge University Press 1987

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