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Attempted vaccination of jirds (Meriones unguiculatus) against Brugia pahangi with radiation attenuated infective larvae

Published online by Cambridge University Press:  05 June 2009

W. Chusattayanond  and
D. A. Denham
W. Chusattayanond
Affiliation:
Department of Microbiology, Mahidol University, Rama VI Road, Bangkok 10400, Thailand
D. A. Denham
Affiliation:
London School of Hygiene and Tropical Medicine, Keppel Street, London WC13 7HT, England
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Abstract

Jirds were vaccinated by three to five subcutaneous (SC) injections of infective larvae of Brugia pahangi which had been irradiated at 25, 45 or 90 krads from a 60Co source. They were challenged either SC or intraperitoneally. Vaccination with four doses of 50 larvae irradiated with 25 krads produced 49·3% resistance to IP challenge worms and 39·8% against SC challenge worms. Five doses of larvae irradiated with 45 krads produced 62% resistance to SC challenge. Three doses of larvae irradiated with 90 krads produced 74·9% resistance to SC challenge and five doses produced 76·2% resistance. The reasons why irradiated larvae produce resistance whereas normal larvae do not are discussed.

Keywords

Brugia pahangivaccinationMeriones unguiculatusirradiated larvaejirds
Type
Research Papers
Information
Journal of Helminthology , Volume 60 , Issue 2 , June 1986 , pp. 149 - 155
Copyright
Copyright © Cambridge University Press 1986

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