Hostname: page-component-848d4c4894-hfldf Total loading time: 0 Render date: 2024-05-11T12:44:53.621Z Has data issue: false hasContentIssue false
  • English
  • Français

Antibody responses against Echinococcus multilocularis antigens in naturally infected Rattus norvegicus

Published online by Cambridge University Press:  05 June 2009

A. Ito ,
M. Okamoto ,
H. Kariwa ,
T. Ishiguro ,
A. Hashimoto  and
M. Nakao
A. Ito
Affiliation:
Department of Parasitology, Gifu University School of Medicine, Gifu 500, Japan
M. Okamoto
Affiliation:
Institute of Experimental Animal Sciences, Osaka University Medical School, Suita 565, Japan
H. Kariwa
Affiliation:
Department of Environmental Veterinary Sciences, Graduate School of Veterinary Medicine, Hokkaido University, Sapporo 060, Japan
T. Ishiguro
Affiliation:
Department of Parasitology, Gifu University School of Medicine, Gifu 500, Japan
A. Hashimoto
Affiliation:
Department of Veterinary Clinical Sciences, Graduate School of Veterinary Medicine, Hokkaido University, Sapporo 060, Japan
M. Nakao
Affiliation:
Department of Parasitology, Asahikawa Medical College, Asahikawa 078, Japan
Get access Rights & Permissions [Opens in a new window]

Abstract

Two Norway rats, Rattus norvegicus, were found to be naturally infected with Echinococcus multilocularis in Japan. One of them was simultaneously infected with at least three different sized metacestodes of Taenia taeniaeformis. These two R. norvegicus rats and another R. norvegicus naturally infected with T. taeniaeformis and Capillaria hepatica were examined to see if they showed any antibody responses against these two cestode parasites with the view to obtaining more information on the importance of rats as the intermediate host for E. multilocularis. These R. norvegicus showed very poor antibody responses against the two cestode species, although the Wistar rats, R. rattus, experimentally infected with a single smaller sized metacestode of T. taeniaeformis showed stronger responses not only against T. taeniaeformis but also against E. multilocularis. Therefore the three R. norvegicus naturally infected with E. multilocularis and/or T. taeniaeformis demonstrated virtually no immune response, at least against these cestodes.

Type
Research Note
Information
Journal of Helminthology , Volume 70 , Issue 4 , December 1996 , pp. 355 - 357
Copyright
Copyright © Cambridge University Press 1996

Access options

Get access to the full version of this content by using one of the access options below. (Log in options will check for institutional or personal access. Content may require purchase if you do not have access.)

References

Ito, A., Bøgh, H.O., Lightowlers, M.W., Mitchell, G.F., Takami, T., Kamiya, M., Onitake, K. & Rickard, M.D. (1991) Vaccination against Taenia taeniaeformis infection in rats using a recombinant protein and preliminary analysis of the induced antibody response. Molecular and Biochemical Parasitology 44, 43–52.CrossRefGoogle ScholarPubMed
Ito, A., Nakao, M., Kutsumi, H., Lightowlers, M.W., Itoh, M. & Sato, S. (1993) Serodiagnosis of alveolar hydatid disease by Western blotting. Transactions of the Royal Society of Tropical Medicine and Hygiene 87, 170–172.CrossRefGoogle ScholarPubMed
Ito, A., Nakao, M., Ito, M., Matsuzaki, T., Kamiya, M. & Kutsumi, H. (1994) Antibody responses in the wild vole, Clethrionomys rufocanus bedfordiae, naturally infected with Echinococcus multilocularis by Western blotting. Journal of Helminthology 68, 267–269.CrossRefGoogle ScholarPubMed
Iwaki, T., Hatakeyama, S., Nonaka, N., Miyaji, S., Yokohata, Y., Okamoto, M., Ooi, H-K., Oku, Y. & Kamiya, M. (1993) Other hepatid helminths in rodents and insectivores in Hokkaido, Japan, from 1985 to 1992. Japanese Journal of Parasitology 42, 502–506.Google Scholar
Iwaki, T., Inohara, J., Oku, Y., Shibahara, T. & Kamiya, M. (1995) Infectivity to rats with eggs of the Echinococcus multilocularis isolated from a Norway rat in Hokkaido, Japan. Japanese Journal of Parasitology 44, 32–33.Google Scholar
Okamoto, M., Fujita, S., Arikawa, J., Kurosawa, T., Oku, Y. & Kamiya, M. (1991) Natural Echinococcus multilocularis infection in a Norway rat, Rattus norvegicus, in southern Hokkaido, Japan. International Journal for Parasitology 22, 681–684.Google Scholar
Wassom, D.L., DeWitt, C.W. & Grundmann, A.W. (1974). Immunity to Hymenolepis citelli by Peromyscus maniculatus: Genetic control and ecological implications. Journal of Parasitology 60, 47–52.CrossRefGoogle ScholarPubMed