An experimental investigation was conducted to examine acoustic receptivity and subsequent boundary-layer instability evolution for a Blasius boundary layer formed on a flat plate in the presence of two-dimensional and oblique (three-dimensional) surface waviness. The effect of the non-localized surface roughness geometry and acoustic wave amplitude on the receptivity process was explored. The surface roughness had a well-defined wavenumber spectrum with fundamental wavenumber kw. A planar downstream-travelling acoustic wave was created to temporally excite the flow near the resonance frequency of an unstable eigenmode corresponding to kts = kw. The range of acoustic forcing levels, ε, and roughness heights, Δh, examined resulted in a linear dependence of receptivity coefficients; however, the larger values of the forcing combination εΔh resulted in subsequent nonlinear development of the Tollmien–Schlichting (T–S) wave. This study provides the first experimental evidence of a marked increase in the receptivity coefficient with increasing obliqueness of the surface waviness in excellent agreement with theory. Detuning of the two-dimensional and oblique disturbances was investigated by varying the streamwise wall-roughness wavenumber αw and measuring the T–S response. For the configuration where laminar-to-turbulent breakdown occurred, the breakdown process was found to be dominated by energy at the fundamental and harmonic frequencies, indicative of K-type breakdown.