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Thermoneutrality effects on developmental programming of obesity

Published online by Cambridge University Press:  13 September 2022

Mina Desai Open the ORCID record for Mina Desai [Opens in a new window] ,
Adrianna S. Torsoni ,
Marcio A. Torsoni ,
Agnlia Eisaghalian ,
Monica G. Ferrini  and
Michael G. Ross
Mina Desai*
Affiliation:
Perinatal Research Laboratory, The Lundquist Institute at Harbor-UCLA Medical Center, Department of Obstetrics and Gynecology, Torrance, CA, USA Department of Obstetrics and Gynecology, David Geffen School of Medicine, University of California, Los Angeles, CA, USA
Adrianna S. Torsoni
Affiliation:
Laboratory of Metabolic Disorders (Labdime), Faculty of Applied Sciences (FCA) of the University of Campinas (UNICAMP), Limeira/SP, Brazil
Marcio A. Torsoni
Affiliation:
Laboratory of Metabolic Disorders (Labdime), Faculty of Applied Sciences (FCA) of the University of Campinas (UNICAMP), Limeira/SP, Brazil
Agnlia Eisaghalian
Affiliation:
Department of Health and Life Sciences, Charles R. Drew University of Medicine and Science, Los Angeles, CA, USA
Monica G. Ferrini
Affiliation:
Department of Health and Life Sciences, Charles R. Drew University of Medicine and Science, Los Angeles, CA, USA
Michael G. Ross
Affiliation:
Perinatal Research Laboratory, The Lundquist Institute at Harbor-UCLA Medical Center, Department of Obstetrics and Gynecology, Torrance, CA, USA Department of Obstetrics and Gynecology, David Geffen School of Medicine, University of California, Los Angeles, CA, USA Department of Obstetrics and Gynecology, Charles R. Drew University, Los Angeles, CA, USA
*
Address for correspondence: Mina Desai, MS, PhD, The Lundquist Institute at Harbor-UCLA Medical Center, 1124 West Carson Street, MRL Building, Torrance, CA 90502, USA. Email: mdesai@lundquist.org
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Abstract

Developmental programming studies using mouse models have housed the animals at human thermoneutral temperatures (22°C) which imposes constant cold stress. As this impacts energy homeostasis, we investigated the effects of two housing temperatures (22°C and 30°C) on obesity development in male and female offspring of Control and FR dams. Pregnant mice were housed at 22°C (cold-exposed, CE) or 30°C (thermoneutrality, TN) room temperature. At gestational age e10, mice were fed either an ad libitum diet (Control) or were 30% food-restricted (FR) to produce low birth weight newborns. Following delivery, all dams were fed an ad libitum diet and maternal mice continued to nurse their own pups. At 3 weeks of age, offspring were weaned to an ad libitum diet and housed at similar temperatures as their mothers. Body weights and food intake were monitored. At 6 months of age, body composition and glucose tolerance test were determined, after which, brain and adipose tissue were collected for analysis. FR/CE and FR/TN offspring exhibited hyperphagia and were significantly heavier with increased adiposity as compared to their respective Controls. There was sex-specific effects of temperature in both groups. Male offspring at TN were heavier with increased body fat, though the food intake was decreased as compared to CE males. This was reflected by hypertrophic adipocytes and increased arcuate nucleus satiety/appetite ratio. In contrast, female offspring were not impacted by housing temperature. Thus, unlike female offspring, there was a significant interaction of diet and temperature evident in the male offspring with accentuated adverse effects evident in FR/TN males.

Keywords

Maternal undernutritionfood intakearcuate nucleusadipose tissue
Type
Original Article
Information
Journal of Developmental Origins of Health and Disease , Volume 14 , Issue 2 , April 2023 , pp. 223 - 230
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Copyright
© The Author(s), 2022. Published by Cambridge University Press in association with International Society for Developmental Origins of Health and Disease

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