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Periconceptional undernutrition in sheep leads to decreased locomotor activity in a natural environment

Published online by Cambridge University Press:  31 May 2013

E. L. Donovan ,
C. E. Hernandez ,
L. R. Matthews ,
M. H. Oliver ,
A. L. Jaquiery ,
F. H. Bloomfield  and
J. E. Harding
E. L. Donovan
Affiliation:
The Liggins Institute, the University of Auckland, Auckland, New Zealand Gravida: National Centre for Growth and Development, New Zealand
C. E. Hernandez
Affiliation:
The Liggins Institute, the University of Auckland, Auckland, New Zealand Gravida: National Centre for Growth and Development, New Zealand
L. R. Matthews
Affiliation:
AgResearch, Ruakura Research Centre, Hamilton, New Zealand
M. H. Oliver
Affiliation:
The Liggins Institute, the University of Auckland, Auckland, New Zealand Gravida: National Centre for Growth and Development, New Zealand
A. L. Jaquiery
Affiliation:
The Liggins Institute, the University of Auckland, Auckland, New Zealand Gravida: National Centre for Growth and Development, New Zealand
F. H. Bloomfield
Affiliation:
The Liggins Institute, the University of Auckland, Auckland, New Zealand Gravida: National Centre for Growth and Development, New Zealand
J. E. Harding*
Affiliation:
The Liggins Institute, the University of Auckland, Auckland, New Zealand
*
*Address for correspondence: J. E. Harding, Liggins Institute, The University of Auckland, Private Bag 92019, Victoria Street West, Auckland 1142, New Zealand. (Email j.harding@auckland.ac.nz)
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Abstract

Maternal undernutrition during pregnancy increases offspring obesity and metabolic disease risk. We hypothesized that periconceptional undernutrition in sheep from 60 days before conception through to day 30 of gestation (UN) would decrease voluntary locomotor activity in adult offspring. Distance travelled was measured at 18 months of age for ∼48 h in the paddock. Data were analysed using multiple regression analysis, with explanatory variables including sex, nutrition group, birth weight, average time between GPS measurements and percentage of time during the measurement period spent in daylight. Mean (±s.e.) distance walked (m/h) was greater for control (CON) than UN animals, and greater for females than males [110.2 (6.5), CON females; 110.7 (6.3), CON males; 105.1 (5.3), UN females and 95.5 (5.8), UN males; P = 0.02 for nutrition group effect and for sex effect]. Periconceptional undernutrition may lead to a significant decrease in voluntary physical activity in adult offspring.

Keywords

developmental programmingobesityphysical activityundernutrition
Type
Brief Report
Information
Journal of Developmental Origins of Health and Disease , Volume 4 , Issue 4 , August 2013 , pp. 296 - 299
Copyright
Copyright © Cambridge University Press and the International Society for Developmental Origins of Health and Disease 2013 

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