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Bocconia frutescens L. induces neurological defects in rat offspring

Published online by Cambridge University Press:  29 April 2024

V.E. Bolado-García Open the ORCID record for V.E. Bolado-García [Opens in a new window] ,
A.A. Corona-Morales ,
M.A. Núñez-Murrieta ,
A.J. Martínez ,
Y.A. Gheno-Heredia ,
A. Sánchez-Medina  and
I. Santiago-Roque
V.E. Bolado-García*
Affiliation:
Laboratorio de Investigación Genómica y Fisiológica, Facultad de Nutrición, Universidad Veracruzana, Xalapa, Veracruz, Mexico
A.A. Corona-Morales
Affiliation:
Laboratorio de Investigación Genómica y Fisiológica, Facultad de Nutrición, Universidad Veracruzana, Xalapa, Veracruz, Mexico
M.A. Núñez-Murrieta
Affiliation:
Laboratorio de Investigación Genómica y Fisiológica, Facultad de Nutrición, Universidad Veracruzana, Xalapa, Veracruz, Mexico
A.J. Martínez
Affiliation:
Instituto de Neuroetología, Universidad Veracruzana, Xalapa, Veracruz, Mexico
Y.A. Gheno-Heredia
Affiliation:
Facultad de Ciencias Biológicas y Agropecuarias, Universidad Veracruzana, Córdoba Veracruz, Mexico
A. Sánchez-Medina
Affiliation:
Instituto de Química Aplicada, Universidad Veracruzana, Xalapa, Veracruz, Mexico
I. Santiago-Roque
Affiliation:
Laboratorio de Neurotoxicología, Facultad de Bioanálisis, Universidad Veracruzana, Xalapa, Veracruz, Mexico
*
Corresponding author: V.E. Bolado García; Email: vbolado@uv.mx
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Abstract

Nearly 80% of the world’s population trusts traditional medicine and plant-based drug compounds to improve health, and more than 50% of women who participated in a study have used herbal remedies during pregnancy. Bocconia frutescens L. is a plant native to tropical America, where infusion of its leaves has been widely used for the treatment of several gastrointestinal disorders. We have already shown that orogastric consumption of B. frutescens L. during the organogenesis period at concentrations equivalent to human consumption produces teratogenic effects in rats, but effects on progeny development have not yet been studied. In this study, we aimed to investigate the possible association between the consumption of B. frutescens L. at a dose equivalent to that consumed by humans and the neurological development of rat progeny. Pregnant Wistar rats were administered lyophilized B. frutescens L. extract at 300 mg/kg/day or vehicle via the orogastric route during the organogenesis period (gestation days 7–13). The physical development and sensory and motor maturation of their offspring during lactation were analyzed with a battery of reflex and physical tests. B. frutescens L. produced a significant delay in physical development and sensorimotor maturation, compared to the control group. Proton nuclear magnetic resonance spectroscopy analysis showed signals for both flavonoids and alkaloids in the B. frutescens L. extract. We conclude that the delay in physical and neurological development could be interpreted as alterations in the maturation of some neuronal circuitries induced by B. frutescens L.

Keywords

Traditional medicineorganogenesis period and pregnancyflavonoids and alkaloidsphysical developmentneurological development
Type
Original Article
Information
Journal of Developmental Origins of Health and Disease , Volume 15 , 2024 , e8
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Copyright
© The Author(s), 2024. Published by Cambridge University Press in association with The International Society for Developmental Origins of Health and Disease (DOHaD)

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