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Maternal mental health and internalizing and externalizing psychopathology in extremely low birth weight adults

Published online by Cambridge University Press:  22 November 2019

Meena Rangan
Affiliation:
Department of Psychology, Ryerson University, Toronto, ON, Canada
Megan Banting
Affiliation:
Department of Medicine, McMaster University, Hamilton, ON, Canada
Lindsay Favotto
Affiliation:
Department of Health Research Methods, Evidence, and Impact, McMaster University, Hamilton, ON, Canada
Louis A. Schmidt
Affiliation:
Department of Psychology, Neuroscience and Behaviour, McMaster University, Hamilton, ON, Canada
Saroj Saigal
Affiliation:
Department of Pediatrics, McMaster University, Hamilton, ON, Canada
Ryan J. Van Lieshout
Affiliation:
Department of Psychiatry and Behavioural Neurosciences, McMaster University, Hamilton, ON, Canada
Corresponding
E-mail address:

Abstract

The mental health of adult extremely low birth weight (ELBW) (<1000 g) survivors is poorer than their normal birth weight (NBW) peers. An understanding of the modifiable factors that affect this risk could provide targets for intervention. We set out to determine the extent to which a maternal history of mental health problems influenced mental health in ELBW and NBW offspring in adulthood. A total of 85 ELBW and 88 NBW individuals born between 1977 and 1982 in central west Ontario, Canada self-reported on internalizing (depression, anxiety) and externalizing (attention-deficit hyperactivity and antisocial) problems using the Diagnostic and Statistical Manual of Mental Disorders (DSM) scales of the Young Adult Self-Report at ages 22–26 and 30–35. They also reported on their mother’s maternal mental health using the Family History Screen. An interaction was found between birth weight status and maternal history of an anxiety disorder such that ELBW survivors showed a greater increase in internalizing scores than NBW participants at 22–26 (β = 10.27, p = 0.002) and at 30–35 years of age (β = 12.65, p = 0.002). An interaction was also observed between birth weight and maternal history of mood disorder, with higher externalizing scores in ELBW survivors than NBW adults at 22–26 (β = 7.21, p < 0.0001). ELBW adults appear to be more susceptible to the adverse mental health effects of exposure to maternal mood and anxiety disorders than those born at NBW. These links further highlight the importance of detecting and treating mental health problems in the parents of preterm survivors as a means of attempting to reduce the burden of psychopathology in this population.

Type
Original Article
Copyright
© Cambridge University Press and the International Society for Developmental Origins of Health and Disease 2019

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Footnotes

These authors contributed equally to this work.

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