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The sensitivity of bovine staphylococci, streptococci and corynebacteria to cloxacillin and various other antibiotics

Published online by Cambridge University Press:  01 June 2009

A. Jones ,
T. M. Higgs ,
F. K. Neave  and
A. Smith
A. Jones
Affiliation:
Beecham Research Laboratories, Great West Road, Brentford
T. M. Higgs
Affiliation:
National Institute for Research in Dairying, Shinfield, Reading
F. K. Neave
Affiliation:
National Institute for Research in Dairying, Shinfield, Reading
A. Smith
Affiliation:
National Institute for Research in Dairying, Shinfield, Reading
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Summary

The sensitivities of isolates of bovine staphylococci, corynebacteria and streptococci to various antibiotics were determined. The growth of various strains of Staphylococcus aureus was inhibited by the following range of concentrations of antibiotic: cloxacillin, 0·07 to 0·6 μg/ml; penicillin G, 0·018 to > 250 μg/ml; streptomycin, 1·25 to > 250 µg/ml; novobiocin, 0·15 to 25 μg/ml; chlortetracycline, 0·6 to 10 µg/ml. The concentrations of cloxacillin required to inhibit growth were between 0·15 and 1·25 μg/ml for strains of Streptococcus agalactiae; 0·07 to 0·3 μg/ml for strains of Streptococcus dysgalactiae and 0·15 to 0·6 μg/ml for strains of Streptococcus uberis.

The corynebacteria were generally sensitive to the penicillins (ampicillin, penicillin G, phenethicillin and cloxacillin), but showed least sensitivity to cloxacillin which had a similar activity to that of chlortetracycline, neomycin and oleandomycin. Chloramphenicol and streptomycin were less active than the penicillins and novobiocin showed little activity against Corynebacterium ulcerans.

A clear relationship was confirmed between the sensitivity of staphylococci to cloxacillin and penicillin G. Some indication was found of an association between the sensitivity of staphylococci to cloxacillin and the success of cloxacillin intramammary therapy in the non-lactating udder. There was no evidence of a change in the sensitivity of Staph. aureus following exposure to cloxacillin in the non-lactating udder.

Type
Original Articles
Information
Journal of Dairy Research , Volume 34 , Issue 3 , October 1967 , pp. 249 - 255
Copyright
Copyright © Proprietors of Journal of Dairy Research 1967

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References

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