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Effect of fermented whey with a probiotic bacterium on gut immune system

Published online by Cambridge University Press:  20 January 2020

Gisela García ,
María Emilia Agosto ,
Lilia Cavaglieri  and
Cecilia Dogi
Gisela García
Affiliation:
Universidad Nacional de Río Cuarto, Ruta 36 km. 601, 5800 Río Cuarto, Córdoba, Argentina
María Emilia Agosto
Affiliation:
Universidad Nacional de Río Cuarto, Ruta 36 km. 601, 5800 Río Cuarto, Córdoba, Argentina
Lilia Cavaglieri
Affiliation:
Universidad Nacional de Río Cuarto, Ruta 36 km. 601, 5800 Río Cuarto, Córdoba, Argentina
Cecilia Dogi*
Affiliation:
Universidad Nacional de Río Cuarto, Ruta 36 km. 601, 5800 Río Cuarto, Córdoba, Argentina
*
Author for correspondence: Cecilia Dogi, Email: cdogi@exa.unrc.edu.ar
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Abstract

The aim of the work presented in this Research Communication was to evaluate the effect of fermented whey (FW) with Lactobacillus rhamnosus RC007 in a mice model. BALB/c mice were divided into three groups: control group: animals received orally 0.1 ml of phosphate buffered saline (PBS); FW group: animals received orally 0.1 ml of FW; whey (W) group: animals received orally 0.1 ml of W without fermentation with probiotic bacterium. After 10 d mice were sacrificed. Small intestines were collected for determination of IL-10; IL-6, TNFα, goblet cells and intraepithelial lymphocytes. Increases of all the cytokines assayed were observed in mice that received FW compared to control and W group. The ratio between the anti and pro-inflammatory cytokines (IL-10/TNFα) increased in the group of mice that received FW. The number of goblet cells and intraepithelial lymphocytes were also increased in animals that received FW. The results showed that FW with L. rhamnosus RC007 was able to stimulate and to modulate mouse immune system. Whey fermented by this probiotic bacterium is an interesting alternative for development of a new food additive for pig production, taking advantage of the beneficial properties of probiotic bacterium and the nutritional properties of whey.

Keywords

Feed additivegut immune systemlactic acid bacteriawhey
Type
Research Article
Information
Journal of Dairy Research , Volume 87 , Issue 1 , February 2020 , pp. 134 - 137
Copyright
Copyright © Hannah Dairy Research Foundation 2020

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