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Cardiovascular responses and mammary substrate uptake in Jersey cows treated with pituitary-derived growth hormone during late lactation

Published online by Cambridge University Press:  01 June 2009

Frances M. Fullerton ,
Ivan R. Fleet ,
R. Brian Heap ,
Ian C. Hart  and
T. Ben Mepham
Frances M. Fullerton
Affiliation:
AFRC Institute of Animal Physiology and Genetics Research, Babraham, Cambridge CB2 4AT, UK
Ivan R. Fleet
Affiliation:
AFRC Institute of Animal Physiology and Genetics Research, Babraham, Cambridge CB2 4AT, UK
R. Brian Heap
Affiliation:
AFRC Institute of Animal Physiology and Genetics Research, Babraham, Cambridge CB2 4AT, UK
Ian C. Hart
Affiliation:
AFRC Institute of Animal Physiology and Genetics Research, Babraham, Cambridge CB2 4AT, UK
T. Ben Mepham
Affiliation:
University of Nottingham, Department of Physiology and Environmental Science, Faculty of Agricultural Science, Sutton Bonington, Loughborough LE12 5RD, UK
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Summary

Pituitary-derived bovine growth hormone (bGH) was administered to Jersey cows during late lactation for 7 d. Milk yield increased significantly during treatment and by a maximum of 49·6% on d 7. The magnitude of the increase was similar to that of mammary plasma flow (47·8±18·3%) over the same period. By 15–21 d after treatment, both variables had returned to pretreatment values. With respect to milk composition, bGH had negligible effect on lactose and fat concentrations but there were significant decreases in protein, sodium and chloride. Arterial plasma concentrations of bGH increased substantially during treatment, but the associated rise in insulin was not statistically significant. Haematocrit decreased significantly, the lowest value being recorded 3 d after bGH treatment ceased. Mammary respiratory quotient fell progressively after the start of bGH treatment and reached the lowest recorded value 3 d after treatment ceased (62·2 ± 7·3% of pretreatment value). Glucose and acetate uptake by the mammary gland increased significantly during treatment, increase in glucose uptake being due both to a greater arterio-venous difference and to mammary plasma flow. There was strong evidence that the acute response in increased milk yield was associated with multiple effects in terms of mammary plasma flow and metabolism, as well as haematocrit changes indicative of increased plasma volume.

Type
Original Articles
Information
Journal of Dairy Research , Volume 56 , Issue 1 , February 1989 , pp. 27 - 35
Copyright
Copyright © Proprietors of Journal of Dairy Research 1989

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