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Biosynthesis and secretion of milk proteins: a review

Published online by Cambridge University Press:  01 June 2009

Bruce L. Larson
Bruce L. Larson
Affiliation:
Department of Dairy Science, University of Illinois, Urbana, Illinois 61801, USA
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Summary

Recent years have seen a great increase in the knowledge and understanding of milk proteins. Arising from several origins including the blood stream and various cellular sources, many of the proteins found in milk are products of the secretory cells directly involved in the synthesis and secretion processes of various milk components. The lactation-specific proteins present in major amounts are synthesized in the rough endoplasmic reticulum (RER) under genetic control and undergo further post-translational modifications in their secretory route from the RER through the Golgi apparatus and secretory vesicles before ejection into the lumen with other milk components. Various molecular aspects of these mechanisms and their control are now understood, but many remain to be described.

Type
Section A. Biological Aspects of Milk Proteins
Information
Journal of Dairy Research , Volume 46 , Issue 2: Symposium on the Physics and Chemistry of Milk Proteins , April 1979 , pp. 161 - 174
Copyright
Copyright © Proprietors of Journal of Dairy Research 1979

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References

REFERENCES

Anderson, M. & Cawston, T. E. (1975). Journal of Dairy Research 42, 459.CrossRefGoogle Scholar
Anderson, R. R. (1974). In Lactation: A Comprehensive Treatise, vol. I, p. 97. (Eds Larson, B. L. and Smith, V. R..) New York: Academic Press.Google Scholar
Anderson, R. R. (1978). In Lactation: A Comprehensive Treatise, vol. IV, p. 3. (Ed. Larson, B. L..) New York: Academic Press.Google Scholar
Barry, J. M. (1961). In Milk: The Mammary Gland and Its Secretion, vol. I, p. 389. (Eds Kon, S. K. and Cowie, A. T..) London: Academic Press.Google Scholar
Baumrucker, C. R. (1978). In Lactation: A Comprehensive Treatise, vol. IV, p. 463. (Ed. Larson, B. L..) New York: Academic Press.Google Scholar
Baumrucker, C. R. & Pocius, P. A. (1978). Journal of Dairy Science 61, 309.CrossRefGoogle Scholar
Bingham, E. W. & Farrell, H. M. Jr (1974). Journal of Biological Chemistry 249, 3647.CrossRefGoogle Scholar
Bingham, E. W. & Farrell, H. M. Jr (1977). Journal of Dairy Science 60, 1199.CrossRefGoogle Scholar
Blobel, G. & Dobberstein, B. (1975). Journal of Cell Biology 67, 852.CrossRefGoogle Scholar
Blobel, G. & Sabatini, D. D. (1971). Biomembranes 2, 193.CrossRefGoogle Scholar
Bracker, C. E., Grove, S. N., Heintz, C. E. & Morré, D. J. (1971). Cytobiologie 4, 1.Google Scholar
Brandon, M. R., Watson, D. L. & Lascelles, A. K. (1971). Australian Journal of Experimental Biology and Medical Sciences 49, 613.CrossRefGoogle Scholar
Brown, R. C., Fish, W. W., Hudson, B. G. & Ebner, K. E. (1977). Biochimica et Biophysica Acta 491, 82.CrossRefGoogle Scholar
Butler, J. E. (1974). In Lactation: A Comprehensive Treatise, vol. III, p. 217. (Eds Larson, B. L. and Smith, V. R..) New York: Academic Press.Google Scholar
Christensen, H. N. (1975). Biological Transport. London: W. A. Benjamin, Inc.Google Scholar
Craig, R. K., Brown, P. A., Harrison, O. S., Mcilreavy, D. & Campbell, P. N. (1976). Biochemical Journal 160, 57.CrossRefGoogle Scholar
Craig, R. K. & Campbell, P. N. (1978). In Lactation: A Comprehensive Treatise, vol. IV, p. 387. (Ed. Larson, B. L.). New York: Academic Press.Google Scholar
Davis, C. L. & Bauman, D. E. (1974). In Lactation: A Comprehensive Treatise, vol. II, p. 3. (Eds Larson, B. L. and Smith, V. R.). New York: Academic Press.Google Scholar
Denamur, R. (1974). In Lactation: A Comprehensive Treatise, vol. I, p. 413. (Eds Larson, B. L. and Smith, R..) New York: Academic Press.Google Scholar
Ebner, K. E. & Schanbacher, F. S. (1974). In Lactation: A Comprehensive Treatise, vol. II, p. 77. (Eds Larson, B. L. and Smith, V. R..) New York: Academic Press.Google Scholar
Eigel, W. N. (1977). Journal of Dairy Science 60, 1399.CrossRefGoogle Scholar
Elder, J. H. & Morré, D. J. (1976). Journal of Biological Chemistry 251, 5054.CrossRefGoogle Scholar
Folley, S. J. (1949). Biological Reviews 24, 316.CrossRefGoogle Scholar
Franklin, R. M., Kenyon, K. R. & Tomasi, T. B. Jr (1973). Journal of Immunology 110, 984.CrossRefGoogle Scholar
Gaye, P. & Houdebine, L. M. (1975). Nucleic Acids Research 2, 707.CrossRefGoogle Scholar
Gordon, W. G. & Groves, M. L. (1975). Journal of Dairy Science 58, 574.CrossRefGoogle Scholar
Grosvenor, C. E. & Mena, F. (1974). In Lactation: A Comprehensive Treatise, vol. I, p. 227. (Eds Larson, B. L. and Smith, V. R..) New York: Academic Press.Google Scholar
Groves, M. L. (1971). In Milk Proteins: Chemistry and Molecular Biology, vol. II, p. 367. (Ed. McKenzie, H. A..) New York: Academic Press.CrossRefGoogle Scholar
Groves, M. L. & Gordon, W. G. (1970). Archives of Biochemistry and Biophysics 140, 47.CrossRefGoogle Scholar
Harrison, O. S., Craig, R. K. & Campbell, P. N. (1976). Biochemical Society Transactions 4, 340.CrossRefGoogle Scholar
Head, J. R. & Beer, A. E. (1978). In Lactation: A Comprehensive Treatise, vol. IV, p. 337. (Ed Larson, B. L..) New York: Academic Press.Google Scholar
Hollmann, K. H. (1974). In Lactation: A Comprehensive Treatise, vol. I, p. 3 (Eds Larson, B. L. and Smith, V. R..) New York: Academic Press.Google Scholar
Houdebine, L. M. (1976a). Nucleic Acids Research 3, 615.CrossRefGoogle Scholar
Houdebine, L. M. (1976b). European Journal of Biochemistry 68, 219.CrossRefGoogle Scholar
Houdebine, L. M. & Gaye, P. (1975). Nucleic Acids Research 2, 165.CrossRefGoogle Scholar
Houdebine, L. M., Gaye, P. & Favre, A. (1974). Nucleic Acids Research 1, 413.CrossRefGoogle Scholar
Jenness, R. (1974). In Lactation: A Comprehensive Treatise, vol. III, p. 1 (Eds Larson, B. L. and Smith, V. R..) New York: Academic Press.Google Scholar
Johke, T. (1978). In Lactation: A Comprehensive Treatise, vol. IV, p. 513. (Ed. Larson, B. L..) New York: Academic Press.Google Scholar
Jones, E. A. (1978). In Lactation: A Comprehensive Treatise, vol. IV, p. 371. (Ed. Larson, B. L..) New York: Academic Press.Google Scholar
Keenan, T. W., Franke, W. W., Mather, I. H. & Morré, D. J. (1978). In Lactation: A Comprehensive Treatise, vol. IV, p. 405. (Ed. Larson, B. L..) New York: Academic Press.Google Scholar
Keenan, T. W., Freudenstein, C. & Franke, W. W. (1977). Cytobiologie 14, 259.Google Scholar
Keenan, T. W. & Huang, C. M. (1972). Journal of Dairy Science 55, 1580.Google Scholar
Keenan, T. W., Huang, C. M. & Morré, D. J. (1972). Journal of Dairy Science 55, 1577.CrossRefGoogle Scholar
Keenan, T. W., Morré, D. J. & Huang, C. M. (1974). In Lactation: A Comprehensive Treatise, vol. II, p. 191. (Eds Larson, B. L. and Smith, V. R..) New York: Academic Press.Google Scholar
Keenan, T. W., Morré, D. J., Olson, D. E., Yunghans, W. N. & Patton, S. (1970). Journal of Cell Biology 44, 80.CrossRefGoogle Scholar
Kemler, R., Mossmann, H., Strohmaier, U., Kickhofen, B. & Hammer, D. K. (1972). European Journal of Immunology 5, 003.Google Scholar
Kobylka, D. & Carraway, K. L. (1973). Biochimica et Biophysica Acta 307, 133.CrossRefGoogle Scholar
Larson, B. L. & Gillespie, D. C. (1957). Journal of Biological Chemistry 227, 565.CrossRefGoogle Scholar
Larson, B. L. & Heoarty, H. M. (1977). Journal of Dairy Science 60, 1223.CrossRefGoogle Scholar
Larson, B. L. & Jorgensen, G. N. (1974). In Lactation: A Comprehensive Treatise, vol. II, p. 115. (Eds Larson, B. L. and Smith, V. R..) New York: Academic Press.Google Scholar
Lascelles, A. K. & Lee, C. S. (1978). In Lactation: A Comprehensive Treatise, vol. IV, p. 115. (Ed. Larson, B. L..) New York: Academic Press.Google Scholar
Lin, C. T. & Chang, J. P. (1975). Science 190, 465.CrossRefGoogle Scholar
Linzell, J. L. (1974). In Lactation: A Comprehensive Treatise, vol. I, p. 143. (Eds Larson, B. L. and Smith, V. R..) New York: Academic Press.Google Scholar
Linzell, J. L. & Peaker, M. (1971). Physiological Reviews 51, 564.CrossRefGoogle Scholar
Linzell, J. L. & Peaker, M. (1964). Journal of Physiology 243, 129.CrossRefGoogle Scholar
Mckenzie, D. D. S. & Lascelles, A. K. (1968). Australian Journal of Biology and Medical Science 46, 285.CrossRefGoogle Scholar
Mckenzie, H. A. (1971). Milk Proteins: Chemistry and Molecular Biology, vols I and II. New York: Academic Press.Google Scholar
Mckenzie, R. M. & Larson, B. L. (1978 a). Journal of Dairy Science 61, 714.CrossRefGoogle Scholar
Mckenzie, R. M. & Larson, B. L. (1978 b). Journal of Dairy Science 61, 723.CrossRefGoogle Scholar
Magee, S. C, Geren, C. R. & Ebner, K. E. (1976). Biochimica et Biophysica Acta 420, 187.CrossRefGoogle Scholar
Mangino, M. E. & Brunner, J. R. (1977). Journal of Dairy Science 60, 1208.CrossRefGoogle Scholar
Mather, I. H., Weber, K. & Keenan, T. W. (1977). Journal of Dairy Science 60, 394.CrossRefGoogle Scholar
Milstein, C., Brownlee, G. G., Cartwright, E. M., Jarvis, J. M. & Proudfoot, N. J. (1974). Nature, London 252, 354.CrossRefGoogle Scholar
Milstein, C., Brownlee, G. G., Harrison, T. M. & Matthews, M. B. (1972). Nature, London 239, 193.Google Scholar
Morré, D. J. (1975). Annual Reviews of Plant Physiology 26, 441.CrossRefGoogle Scholar
Morré, D. J., Keenan, T. W. & Huang, C. M. (1974). Cytopharmacology 2, 107.Google Scholar
Morré, D. J., Keenan, T. W. & Mollenhauer, H. H. (1971). Advances in Cytopharmacology 2, 107.Google Scholar
Morré, D. J. & Mollenhauer, H. H. (1974). In Dynamics of Plant Ultrastructure, p. 84. (Ed. Robards, A. W..) New York: McGraw-Hill.Google Scholar
Newbould, F. H. S. (1974). In Lactation: A Comprehensive Treatise, vol. II, p. 269. (Eds Larson, B. L. and Smith, V. R..) New York: Academic Press.Google Scholar
Newman, R. A., Harrison, R. & Uhlenbruck, G. (1976). Biochimica et Biophysica Acta 433, 344.CrossRefGoogle Scholar
Palade, G. (1975). Science 189, 347..CrossRefGoogle Scholar
Patton, S. (1976). Journal of Dairy Science 59, 1414.CrossRefGoogle Scholar
Patton, S. & Keenan, T. W. (1975). Biochimica et Biophysica Acta 415, 273.CrossRefGoogle Scholar
Peaker, M. (1978). In Lactation: A Comprehensive Treatise, vol. IV, p. 437. (Ed. Larson, B. L..) New York: Academic Press.Google Scholar
Pitelka, D. R. (1978). In Lactation: A Comprehensive Treatise, vol. IV, p. 41. (Ed. Larson, B. L..) Now York: Academic Press.Google Scholar
Pitelka, D. R., Hamamoto, S. T., Duafala, J. G. & Nemanic, M. K. (1973). Journal of Cell Biology 56, 797.CrossRefGoogle Scholar
Powell, J. T., Jarlfors, U. & Brew, K. (1977). Journal of Cell Biology 72, 617.CrossRefGoogle Scholar
Proudfoot, N. J. & Brownlee, G. G. (1976). British Medical Bulletin 32, 251.CrossRefGoogle Scholar
Raynaud, A. (1961). In Milk: The Mammary Gland and Its Secretion, vol. I, p. 3. (Eds Kon, S. K. and Cowie, A. T..) New York: Academic Press.Google Scholar
Rodewald, R. (1973). Journal of Cell Biology 58, 189.CrossRefGoogle Scholar
Rosen, J. M. (1976). Biochemistry 15, 5263.CrossRefGoogle Scholar
Rosen, J. M. & Barker, S. W. (1976). Biochemistry 15, 5272.CrossRefGoogle Scholar
Rosen, J. M., Woo, S. L. C. & Comstock, J. P. (1975). Biochemistry 14, 2895.CrossRefGoogle Scholar
Saacke, R. G. & Heald, C. W. (1974). In Lactation: A Comprehensive Treatise, vol. II, p. 147. (Eds Larson, B. L. and Smith, V. R..) New York: Academic Press.Google Scholar
Sasaki, M., Larson, B. L. & Nelson, D. R. (1977). Biochimica et Biophysica Acta 497, 160.CrossRefGoogle Scholar
Shahani, K. M., Harper, W. J., Jensen, R. G., Parry, R. M. Jr & Zittle, C. A. (1973). Journal of Dairy Science 56, 531.CrossRefGoogle Scholar
Singer, S. J. (1974). Advances in Enzymology, 19, 1.Google Scholar
Smith, V. R. (1959). Secretion of Milk. Ames: Iowa State College Press.Google Scholar
Sonoda, S., Shigematsu, T. & Schlamowttz, M. (1973). Journal of Immunology 110, 1682.CrossRefGoogle Scholar
Thompson, M. P. & Farrell, H. M. Jr (1974). In Lactation: A Comprehensive Treatise, vol. III, p. 109. (Eds Larson, B. L. and Smith, V. R..) New York: Academic Press.Google Scholar
Tindal, J. S. (1978). In Lactation: A Comprehensive Treatise, vol. IV, p. 67. (Ed. Larson, B. L..) New York: Academic Press.Google Scholar
Topper, Y. J. & Oka, T. (1974). In Lactation: A Comprehensive Treatise, vol. I, p. 327. (Eds Larson, B. L. and Smith, V. R..) New York: Academic Press.Google Scholar
Tucker, H. A. (1974). In Lactation: A Comprehensive Treatise, vol. I, p. 277. (Eds Larson, B. L. and Smith, V. R..) New York: Academic Press.Google Scholar
Turkington, R. W. & Topper, Y. J. (1966). Biochimica et Biophysica Acta 127, 366.CrossRefGoogle Scholar
Wellings, S. R. (1969). In Lactogenesis: The Initiation of Milk Secretion at Parturition, p. 5. (Eds Reynolds, M. and Folley, S. J..) Philadelphia: University of Pennsylvania Press.CrossRefGoogle Scholar
Whitney, R. McL., Brtjnner, J. R., Ebner, K. E., Farreli, H. M. JrJosephson, R. V., Morr, C. V. & Swaisgood, H. E. (1976). Journal of Dairy Science 59, 795.CrossRefGoogle Scholar
Wiegant, H. (1973). Hoppe Seyler's Zeitschrift fur Physiologische Chemie 354, 1049.CrossRefGoogle Scholar