Hostname: page-component-77c89778f8-n9wrp Total loading time: 0 Render date: 2024-07-23T03:29:02.497Z Has data issue: false hasContentIssue false

Short-term effects of selenium supplementation of cows' feed on the content and distribution of selenium, copper and zinc in bovine milk, whey and blood plasma

Published online by Cambridge University Press:  04 August 2008

Tien Hoac
Affiliation:
Biomedical Nutrition, Pure and Applied Biochemistry, Lund University, Lund, Sweden
Jan Stagsted
Affiliation:
Department of Food Science, Research Centre Foulum, Faculty of Agricultural Sciences, University of Aarhus, Tjele, Denmark
Thomas Lundh
Affiliation:
Division of Occupational and Environmental Medicine and Psychiatric Epidemiology, Department of Laboratory Medicine, Lund University Hospital, Lund, Sweden
Jacob H Nielsen
Affiliation:
Department of Food Science, Research Centre Foulum, Faculty of Agricultural Sciences, University of Aarhus, Tjele, Denmark
Björn Åkesson*
Affiliation:
Biomedical Nutrition, Pure and Applied Biochemistry, Lund University, Lund, Sweden Department of Clinical Nutrition, Lund University Hospital, Lund, Sweden
*
*For correspondence; e-mail: bjorn.akesson@tbiokem.lth.se

Abstract

The effect of selenium supplementation of feed on the Se content in bovine milk, whey and plasma, and on the distribution of Se, Zn and Cu in whey and plasma was investigated. In a cross-over study two groups of cows were given a basal feed with 0·16 ppm selenite (approx. 3 mg Se/d) with or without 25 mg yeast Se/d for 2 weeks. In the supplemented group the Se content increased 10-fold in milk, 10-fold in whey and 2-fold in plasma, and after the cessation of the supplementation, selenium in milk decreased with a calculated half-life of 3·5 d. In another experiment, two groups of cows were given either 100 mg yeast Se/d for 1 week or only the basal feed. The increase in Se content in both whole and defatted milk was 40–50-fold, and in whey it was approx. 20-fold. Size-exclusion chromatography of whey using inductively coupled plasma mass spectrometry for detection showed that supplementation increased the proportion of Se in the β-lactoglobulin-α-lactalbumin fraction. Distribution of Cu and Zn was essentially unaffected. In plasma, supplementation increased the Se content in all major Se fractions like selenoprotein P, albumin and low-molecular-weight compounds, but the distribution profiles of Zn and Cu underwent no major changes. The study showed for the first time the rapid kinetics of the Se increase and decrease in milk after the initiation and cessation of supplementation, respectively, and the preferential appearance of Se in the β-lactoglobulin-α-lactalbumin fraction of whey. Milk highly enriched in selenium will be a useful tool for different research purposes.

Type
Research Article
Copyright
Copyright © Proprietors of Journal of Dairy Research 2008

Access options

Get access to the full version of this content by using one of the access options below. (Log in options will check for institutional or personal access. Content may require purchase if you do not have access.)

References

Åkesson, B & Mårtensson, B 1988 Heparin interacts with a selenoprotein in human plasma. Journal of Inorganic Biochemistry 33 257260CrossRefGoogle ScholarPubMed
Alaejos, MS & Romeo, CD 1995 Selenium concentration in milks. Food Chemistry 52 118CrossRefGoogle Scholar
Aro, A, Alfthan, G & Varo, P 1995 Effects of supplementation of fertilizers on human selenium status in Finland. Analyst 120 841843CrossRefGoogle ScholarPubMed
Avissar, N, Slemmon, JR, Palmer, IS & Cohen, HJ 1991 Partial sequence of human plasma glutathione peroxidase and immunologic identification of milk glutathione peroxidase as the plasma enzyme. Journal of Nutrition 121 12431249CrossRefGoogle ScholarPubMed
Awadeh, FT, Abdelrahman, MM, Kincaid, RL & Finley, JW 1998 Effect of selenium supplements on the distribution of selenium among serum proteins in cattle. Journal of Dairy Science 81 10891094CrossRefGoogle ScholarPubMed
Bárány, E, Bergdahl, IA, Schütz, A, Skerfving, S & Oskarsson, A 1997 Inductively coupled plasma mass spectrometry for direct multi-element analysis of diluted human blood and serum. Journal of Analytical Atomic Spectrometry 12 10051009CrossRefGoogle Scholar
Becker, W 2000 [Which foods are the sources of our nutrients?] Vår Föda 3 1620Google Scholar
Blakley, BR & Hamilton, DL 1985 Ceruloplasmin as an indicator of copper status in cattle and sheep. Canadian Journal of Comparative Medicine 49 405408Google ScholarPubMed
Blot, WJ, Li, J-Y, Taylor, PR, Guo, W, Dawsey, SM, Wang, G-C, Yang, CS, Zheng, S-F, Gail, M, Li, G-Y, Yu, Y, Liu, B-Q, Tangrea, J, Sun, Y-H, Liu, F, Fraumeni, JF, Zhang, Y-H Jr & Li, B 1993 Nutrition intervention trials in Linxian, China: supplementation with specific vitamin/mineral combinations, cancer incidence, and disease-specific mortality in the general population. Journal of the National Cancer Institute 15 14831492CrossRefGoogle Scholar
Borglund, M, Åkesson, A & Åkesson, B 1988 Distribution of selenium and glutathione peroxidase in plasma, compared in healthy subjects and rheumatoid arthritis patients. Scandinavian Journal of Clinical Laboratory Investigation 48 2732CrossRefGoogle ScholarPubMed
Borglund, M & Åkesson, B 1988 Effect of selenium supplementation on the distribution of selenium in plasma proteins of healthy subjects. International Journal of Vitamin and Nutrition Research 58 97102Google ScholarPubMed
Brätter, P, Blaso, IN, Negretti de, Brätter VE & Raab, A 1998 Speciation as an analytical aid in trace element research in infant nutrition. Analyst 123 821826CrossRefGoogle ScholarPubMed
Bruzelius, K, Hoac, T, Sundler, R, Önning, G & Åkesson, B 2007 Occurrence of selenoprotein enzymatic activities and mRNA in bovine mammary tissue. Journal of Dairy Science 90 918927CrossRefGoogle Scholar
Burk, RF, Hill, KE & Motley, AK 2001 Plasma selenium in specific and nonspecific forms. Biofactors 14 107114CrossRefGoogle Scholar
Clark, LC, Combs, GF, Turnbull, BW, Slate, EH, Chalker, DK, Chow, J, Davis, LS, Glover, RA, Graham, GF, Gross, EG, Krongrad, A, Lesher, JL Jr, Park, HK, Sanders, BB Jr, Smith, CL & Taylor, JR 1996 Effect of selenium supplementation for cancer prevention in patients with carcinoma of the skin. Journal of the American Medical Association 276 19571963CrossRefGoogle ScholarPubMed
Combs, GF Jr & Combs, S 1986 Selenium in the environment. In: The Role of Selenium in Nutrition, pp. 1533. London, UK: Academic PressCrossRefGoogle Scholar
Conrad, HR & Moxon, AL 1979 Transfer of dietary selenium to milk. Journal of Dairy Science 62 404411CrossRefGoogle ScholarPubMed
Daun, C, Lundh, T, Önning, G & Åkesson, B 2004 Speciation of soluble selenium compounds in muscle from seven animal species using size exclusion chromatography and inductively coupled plasma mass spectrometry. Journal of Analytical Atomic Spectrometry 19 129134CrossRefGoogle Scholar
Deagen, JT, Butler, JA, Zachara, BA & Whanger, PD 1993 Determination of the distribution of selenium between glutathione peroxidase, selenoprotein P and albumin in plasma. Analytical Biochemistry 208 176181CrossRefGoogle ScholarPubMed
EFSA 2006 Opinion of the Scientific Panel on Additives and Products or Substances used in Animal Feed on the safety and efficacy of the product Sel-Plex®2000 as a feed additive according to Regulation (EC) No 1831/2003. EFSA Journal 348 140Google Scholar
Ekholm, P, Ylinen, M, Eurola, M, Koivistoinen, P & Varo, P 1991a Effect of general soil fertilization with sodium selenate in Finland on the selenium content of milk, cheese and eggs. Milchwissenschaft 46 547550Google Scholar
Ekholm, P, Varo, P, Aspila, P, Koivistoinen, P & Syrjälä-Quist, L 1991b Transport of feed selenium to different tissues of bulls. British Journal of Nutrition 66 4955CrossRefGoogle ScholarPubMed
Gierus, M, Schwarz, FJ & Kirchgessner, M 2002 Selenium supplementation and selenium status of dairy cows fed diets based on grass, grass silage or maize silage. Journal of Animal Physiology and Animal Nutrition 86 7482CrossRefGoogle ScholarPubMed
Givens, DI, Allison, R, Cottrill, B & Blake, JS 2004 Enhancing the selenium content of bovine milk through alternation of the form and concentration of selenium in the diet of the dairy cow. Journal of the Science of Food and Agriculture 84 811817CrossRefGoogle Scholar
Gromer, S, Eubel, JK, Lee, BL & Jacob, J 2005 Human selenoproteins at a glance. Cellular and Molecular Life Sciences 62 24142437CrossRefGoogle ScholarPubMed
Hoac, T, Lundh, T, Purup, S, Önning, G, Sejrsen, K & Åkesson, B 2007 Separation of selenium, zinc and copper compounds in bovine whey using size exclusion chromatography linked to inductively coupled plasma mass spectrometry. Journal of Agricultural and Food Chemistry 55 42374243CrossRefGoogle ScholarPubMed
Inagaki, K, Mikuriya, N, Morita, S, Haraguchi, H, Nakahara, Y, Hattori, M, Kinosita, T & Saito, H 2000 Speciation of protein-binding zinc and copper in human blood serum by chelating resin pre-treatment and inductively coupled plasma mass spectrometry. Analyst 125 197203CrossRefGoogle ScholarPubMed
Johnsson, L, Åkesson, B & Alexander, J 1997 Availability of selenium from soils in relation to human nutritional requirements in Sweden—Is there a need for supplementation? Swedish Environmental Protection Agency Stockholm, Sweden, Report 4711Google Scholar
Kantola, M & Vartiainen, T 2001 Changes in selenium, zinc, copper and cadmium contents in human milk during the time when selenium has been supplemented to fertilizers in Finland. Journal of Trace Elements in Medicine and Biology 15 1117CrossRefGoogle Scholar
Knowles, SO, Grace, ND, Wurms, K & Lee, J 1999 Significance of amount and form of dietary selenium on blood, milk and casein selenium concentrations in grazing cows. Journal of Dairy Science 82 429437CrossRefGoogle ScholarPubMed
Köhrle, J, Jakob, F, Contempré, B & Dumont, JE 2005 Selenium, the thyroid, and the endocrine system. Endocrine Reviews 26 944984CrossRefGoogle ScholarPubMed
Kryukov, GV, Castellano, S, Novoselov, SV, Lobanov, AV, Zehtab, O, Guigo, R & Gladyshev, VN 2003 Characterization of mammalian selenoproteomes. Science 300 14391443CrossRefGoogle ScholarPubMed
Linder, MC, Wooten, L, Cerveza, P, Cotton, S, Shulze, R & Lomeli, N 1998 Copper transfer. American Journal of Clinical Nutrition 67 suppl965S971SCrossRefGoogle Scholar
Lindmark-Månsson, H & Åkesson, B 2001 Purification and immunochemical assay of bovine extracellular glutathione peroxidase. International Dairy Journal 11 649655CrossRefGoogle Scholar
Lindmark-Månsson, H, Fondén, R & Pettersson, HE 2003 Composition of Swedish dairy milk. International Dairy Journal 13 409425CrossRefGoogle Scholar
Mangels, AR, Moser-Veillon, PB, Patterson, KY & Veillon, C 1990 Selenium utilization during human lactation by use of stable-isotope tracers. American Journal of Clinical Nutrition 52 621627CrossRefGoogle ScholarPubMed
Masuoka, J, Hegenauer, J, Van Dyke, BR & Saltman, P 1993 Intrinsic stoichiometric equilibrium constants for the binding of zinc (II) and copper (II) to the high affinity site of serum albumin. Journal of Biological Chemistry 268 2153321537CrossRefGoogle Scholar
Meyer, F, Galan, P, Douville, P, Bairati, I, Kelge, P, Bertrais, S, Estaquio, C & Hercberg, S 2005 Antioxidant vitamin and mineral supplementation and prostate cancer prevention in the SU.VI.MAX trial. International Journal of Cancer 116 182186CrossRefGoogle ScholarPubMed
Nicholson, JWG, St-Laurent, AM, McQueen, RE & Charmley, E 1991 The effect of feeding organically bound selenium and α-tocopherol to dairy cows on susceptibility of milk to oxidation. Canadian Journal of Animal Science 71 135143CrossRefGoogle Scholar
Nordic Nutrition Recommendations 2004 Nord 2004:13Google Scholar
Önning, G, Daun, C, Drevelius, M, Lindmark, Månsson H, Lundh, T & Åkesson, B 2004 Selenium and selenoproteins in food. Metal Ions in Biology and Medicine, Volume 8 (Eds Khassanova, L, Collery, P, Maynard, I, Khassanova, Z & Étienne, JC) pp. 7981Google Scholar
Ortman, K & Pehrson, B 1999 Effect of selenate as a feed supplement to dairy cows in comparison to selenite and selenium yeast. Journal of Animal Science 77 33653370CrossRefGoogle ScholarPubMed
Palacios, Ò, Encinar, JR, Bertin, G & Lobinski, R 2005 Analysis of the selenium species distribution in cow blood by size exclusion liquid chromatography-inductively coupled plasma collision cell mass spectrometry (SEC-ICPccMS). Analytical and Bioanalytical Chemistry 383 516522CrossRefGoogle ScholarPubMed
Palacios, Ò, Encinar, JR, Schaumlöffel, D & Lobinski, R 2006 Fractionation of selenium-containing proteins in serum by multiaffinity liquid chromatography before size-exclusion chromatography-ICPMS. Analytical and Bioanalytical Chemistry 384 12761283CrossRefGoogle ScholarPubMed
Papp, LV, Lu, J, Holmgren, A & Khanna, KK 2007 From selenium to selenoproteins: synthesis, identity, and their role in human health. Antioxidants & Redox Signaling 9 775806CrossRefGoogle ScholarPubMed
Perrone, L, Di Palma, L, Di Toro, R, Gialanella, G & Moro, R 1994 Interaction of trace elements in a longitudinal study of human milk from full-term and preterm mothers. Biological Trace Element Research 41 321330CrossRefGoogle Scholar
Ravn-Haren, G, Bügel, S, Krath, BN, Hoac, T, Stagsted, J, Jørgensen, K, Bresson, JR, Larsen, EH & Dragsted, LO 2008 A short-term intervention trial with selenate, selenium-enriched yeast and selenium-enriched milk: effects on oxidative defence regulation. British Journal of Nutrition 99 883892CrossRefGoogle ScholarPubMed
Rayman, MP 1997 Dietary selenium: time to act. British Medical Journal 314 387388CrossRefGoogle ScholarPubMed
Ruiz, Encinar J, Schaumlöffel, D, Orga, Y & Lobinski, R 2004 Determination of selenomethionine and selenocysteine in human serum using speciated isotope dilution-capillary HPLC-inductively coupled plasma collision cell mass spectrometry. Analytical Chemistry 76 66356642Google Scholar
Schweizer, U, Michaelis, M, Köhrle, J & Schomburg, L 2004 Efficient selenium transfer from mother to offspring in selenoprotein-P-deficient mice enables dose-dependent rescue of phenotypes associated with selenium deficiency. Biochemical Journal 378 2126CrossRefGoogle ScholarPubMed
Stagsted, J, Hoac, T, Åkesson, B & Nielsen, JH 2005 Dietary supplementation with organic selenium (Sel-Plex) alters oxidation in raw and pasteurised milk. In: Nutritional Technology in the Feed and Food Industries, pp. 249257 (Eds Lyons, TP & Jacques, KA). Nottingham, UK: Nottingham University PressGoogle Scholar
Stowe, HD & Herdt, TH 1992 Clinical assessment of selenium status of livestock. Journal of Animal Science 70 39283933CrossRefGoogle ScholarPubMed
Trumbo, PR 2005 The level of evidence for permitting a qualified health claim: FDA's review of the evidence for selenium and cancer and vitamin E and heart disease. Journal of Nutrition 135 354356CrossRefGoogle ScholarPubMed
Ullrey, DE 1992 Basis for regulation of selenium supplements in animal diets. Journal of Animal Science 70 39223927CrossRefGoogle ScholarPubMed
Van Dael, P 1992 Comparative Study on the Distribution of Selenium in Cow's, Goat, Sheep and Human Milk. Doctoral thesis, University of Antwerpen, The NetherlandsGoogle Scholar
Weiss, WP, Hogan, JS, Smith, KL & Hoblet, KH 1990 Relationships among selenium, vitamin E and mammary gland health in commercial dairy herds. Journal of Dairy Science 73 381390CrossRefGoogle ScholarPubMed
Xia, Y, Hill, KE, Byrne, DW, Xu, J & Burk, RF 2005 Effectiveness of selenium supplements in a low-selenium area of China. American Journal of Clinical Nutrition 81 829834CrossRefGoogle Scholar