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Identification of an immune modulation locus utilising a bovine mammary gland infection challenge model

Published online by Cambridge University Press:  22 May 2018

Mathew D Littlejohn
Affiliation:
LIC, Hamilton, New Zealand
Sally-Anne Turner
Affiliation:
DairyNZ, Hamilton, New Zealand
Caroline G Walker
Affiliation:
DairyNZ, Hamilton, New Zealand
Sarah D Berry
Affiliation:
Growing up in New Zealand, University of Auckland, Auckland, New Zealand
Kathryn Tiplady
Affiliation:
LIC, Hamilton, New Zealand
Ric G Sherlock
Affiliation:
LIC, Hamilton, New Zealand
Greg Sutherland
Affiliation:
School of Medical Sciences, University of Sydney, Sydney, Australia
Simon Swift
Affiliation:
School of Medical Sciences, University of Auckland, Auckland, New Zealand
Dorian Garrick
Affiliation:
Massey University, Palmerston North, New Zealand
S Jane Lacy-Hulbert
Affiliation:
DairyNZ, Hamilton, New Zealand
Scott McDougall
Affiliation:
Cognsoco, Anexa Animal Health, Morrinsville, New Zealand
Richard J Spelman
Affiliation:
LIC, Hamilton, New Zealand
Russell G Snell
Affiliation:
School of Biological Sciences, University of Auckland, Auckland, New Zealand
J Eric Hillerton
Affiliation:
DairyNZ, Hamilton, New Zealand
Corresponding

Abstract

Inflammation of the mammary gland following bacterial infection, commonly known as mastitis, affects all mammalian species. Although the aetiology and epidemiology of mastitis in the dairy cow are well described, the genetic factors mediating resistance to mammary gland infection are not well known, due in part to the difficulty in obtaining robust phenotypic information from sufficiently large numbers of individuals. To address this problem, an experimental mammary gland infection experiment was undertaken, using a Friesian-Jersey cross breed F2 herd. A total of 604 animals received an intramammary infusion of Streptococcus uberis in one gland, and the clinical response over 13 milkings was used for linkage mapping and genome-wide association analysis. A quantitative trait locus (QTL) was detected on bovine chromosome 11 for clinical mastitis status using micro-satellite and Affymetrix 10 K SNP markers, and then exome and genome sequence data used from the six F1 sires of the experimental animals to examine this region in more detail. A total of 485 sequence variants were typed in the QTL interval, and association mapping using these and an additional 37 986 genome-wide markers from the Illumina SNP50 bovine SNP panel revealed association with markers encompassing the interleukin-1 gene cluster locus. This study highlights a region on bovine chromosome 11, consistent with earlier studies, as conferring resistance to experimentally induced mammary gland infection, and newly prioritises the IL1 gene cluster for further analysis in genetic resistance to mastitis.

Type
Research Article
Copyright
Copyright © Hannah Dairy Research Foundation 2018 

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References

Baret, PV, Knott, SA & Visscher, PM 1998 On the use of linear regression and maximum likelihood for QTL mapping in half-sib designs. Genetics Research 72 149158CrossRefGoogle ScholarPubMed
Boichard, D, Grohs, C, Bourgeois, F, Cerqueira, F, Faugeras, R, Neau, A, Rupp, R, Amigues, Y, Boscher, MY & Levéziel, H 2003 Detection of genes influencing economic traits in three French dairy cattle breeds. Genetics Selection Evolution 35 77101CrossRefGoogle ScholarPubMed
Haley, CS, Knott, SA & Elsen, JM 1994 Mapping quantitative trait loci in crosses between outbred lines using least squares. Genetics 136 11951207Google ScholarPubMed
Harmon, RJ 1994 Physiology of mastitis and factors affecting somatic cell counts. Journal of Dairy Science 77 21032112CrossRefGoogle ScholarPubMed
Heringstad, B, Klemetsdal, G & Ruane, J 2000 Selection for mastitis resistance in dairy cattle: a review with focus on the situation in the Nordic countries. Livestock Production Science 64 95106CrossRefGoogle Scholar
Hill, AW 1988 Protective effect of previous intramammary infection with Streptococcus uberis against subsequent clinical mastitis in the cow. Research in Veterinary Science 44 386387Google ScholarPubMed
Hogan, J, Gonzalez, R, Harmon, R, Nickerson, S, Oliver, S, Pankey, JW & Smith, KL 1999 Laboratory Handbook on Bovine Mastitis. Madison, WI, USA: National Mastitis Council IncGoogle Scholar
Holmberg, M & Andersson-Eklund, L 2004 Quantitative trait loci affecting health traits in Swedish dairy cattle. Journal of Dairy Science 87 26532659CrossRefGoogle ScholarPubMed
Klungland, H, Sabry, A, Heringstad, B, Olsen, HG, Gomez-Raya, L, Våge, DI, Olsaker, I, Ødegård, J, Klemetsdal, G, Schulman, N, Vilkki, J, Ruane, J, Aasland, M, Rønningen, K & Lien, S 2001 Quantitative trait loci affecting clinical mastitis and somatic cell count in dairy cattle. Mammalian Genome 12 837842CrossRefGoogle ScholarPubMed
Lopez-Benavides, MG, Williamson, JH, McGowan, JE, Lacy-Hulbert, SJ, Jago, JG, Davis, KL & Woolford, MW 2006 Mastitis in cows milked in an automated or conventional milking system in New Zealand. Proceedings of the New Zealand Society for Animal Production 66 252257Google Scholar
Lund, MS, Sahana, G, Andersson-Eklund, L, Hastings, N, Fernandez, A, Schulman, N, Thomsen, B, Viitala, S, Sabry, A, Viinalass, H & Vilkki, J 2007 Joint analysis of quantitative trait loci for clinical mastitis and somatic cell score on five chromosomes in three Nordic dairy cattle breeds. Journal of Dairy Science 90 52825290CrossRefGoogle ScholarPubMed
Lund, MS, Guldbrandtsen, B, Buitenhuis, AJ, Thomsen, B & Bendixen, C 2008 Detection of quantitative trait loci in Danish Holstein cattle affecting clinical mastitis, somatic cell score, udder conformation traits, and assessment of associated effects on milk yield. Journal of Dairy Science 91 40284036CrossRefGoogle ScholarPubMed
Lush, JL 1949 Inheritance of susceptibility to mastitis. Journal paper no. J-1718, Iowa Agricultural Experiment Station, Project no, 1053, pp. 121125Google Scholar
McDougall, S 2002 Bovine mastitis: epidemiology, treatment and control. New Zealand Veterinary Journal 50(Suppl) 8184CrossRefGoogle Scholar
McDougall, S, Parkinson, TJ, Leyland, M, Anniss, FM & Fenwick, SG 2004 Duration of infection and strain variation in Streptococcus uberis isolated from cows’ milk. Journal of Dairy Science 87 20622072CrossRefGoogle ScholarPubMed
Nicklin, MJ, Barton, JL, Nguyen, M, FitzGerald, MG, Duff, GW, & Kornman, K, 2002 A sequence-based map of the nine genes of the human interleukin-1 cluster. Genomics 79 718725CrossRefGoogle ScholarPubMed
NMC 2016 Current Concepts of Bovine Mastitis, 5th edn. pp. 80. New Prague, MI, USA: National Mastitis CouncilGoogle Scholar
Ron, M, Feldmesser, E, Golik, M, Tager-Cohen, I, Kliger, D, Reiss, V, Domochovsky, R, Alus, O, Seroussi, E, Ezra, E & Weller, JI 2004 A complete genome scan of the Israeli Holstein population for quantitative trait loci by a daughter design. Journal of Dairy Science 87 476490CrossRefGoogle ScholarPubMed
Sanders, KM, McDougall, S, Stanley, GE, Johnson, DL, Spelman, RJ & Harcourt, SJ 2006 Responses and factors affecting intramammary infection rates resulting from infusion of a Streptococcus uberis strain in Friesian-Jersey crossbred cows. Proceedings of the New Zealand Society for Animal Production 66 7076Google Scholar
Schulman, NF, Sahana, G, Iso-Touru, T, Lund, MS, Andersson-Eklund, L, Viitala, SM, Värv, S, Viinalass, H & Vilkki, JH 2009 Fine mapping of quantitative trait loci for mastitis resistance on bovine chromosome 11. Animal Genetics 40 509515CrossRefGoogle ScholarPubMed
Sims, JE & Smith, DE 2010 The IL-1 family: regulators of immunity. Nature Reviews Immunology 10 89102CrossRefGoogle Scholar
Spelman, RJ, Milllar, FM, Hooper, JD, Thielen, M & Garrick, DJ 2001 Experimental design for the QTL trial involving New Zealand Friesian and Jersey breeds. Proceedingsof the Association for Advancemnet in Animal Breeding and Genetics, Queenstown, New Zealand, pp. 393396Google Scholar
Tal-Stein, R, Fontanesi, L, Dolezal, M, Scotti, E, Bagnato, A, Russo, V, Canavesi, F, Friedmann, A, Soller, M & Lipkin, E 2010 A genome scan for quantitative trait loci affecting milk somatic cell score in Israeli and Italian Holstein cows by means of selective DNA pooling with single- and multiple-marker mapping. Journal of Dairy Science 93 49134927CrossRefGoogle ScholarPubMed
Ward, AH 1938 Preliminary report on inheritance of “susceptibility” to severe udder infection (mastitis). New Zealand Journal of Science and Technology 20 109A114AGoogle Scholar
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Identification of an immune modulation locus utilising a bovine mammary gland infection challenge model
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