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A genetic isolate in the French Pyrenees: probabilities of origin of genes and inbreeding

Published online by Cambridge University Press:  31 July 2008

Jean Louis Serre ,
Lucienne Jakobi  and
Marie-claude Babron
Jean Louis Serre
Affiliation:
Laboratoire de Génétique Epidémiologique, INSERM U-155, Paris, France Université Pierre et Marie Curie, Paris, France
Lucienne Jakobi
Affiliation:
Centre de Recherches Anthropologiques du Musée de l'Homme, Paris, France
Marie-claude Babron
Affiliation:
Laboratoire de Génétique Epidémiologique, INSERM U-155, Paris, France
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Summary

The genetic structure and its recent evolution in a small isolated village in the French Pyrenees, Arthez-d'Asson, have been characterized by calculating the probabilities of origin of genes and inbreeding values at every generation since the 17th century.

Arthez-d'Asson appears to be one of the most inbred populations in France, with an inbreeding coefficient of approximately 0·5%. This is due first to genetical and cultural isolation, and secondly to migration out of the village towards towns at the turn of the century. The valley of Ouzom, in which Arthez-d'Asson lies, constitutes a hierarchical population and some cultural and genetical turnover is drawing back to the valley genes which have been absent for some generations.

Type
Research Article
Information
Journal of Biosocial Science , Volume 17 , Issue 4 , October 1985 , pp. 405 - 414
Copyright
Copyright © 1985, Cambridge University Press

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