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Effect of a duodenal infusion of methionine on erythrocyte reduced glutathione of sheep

Published online by Cambridge University Press:  27 March 2009

R. M. W. Sumner ,
D. W. Peter  and
P. G. Board
R. M. W. Sumner
Affiliation:
Departments of Biochemistry and Nutrition, and Physiology, University of New England, ArmidaleN.S.W. 2351, Australia
D. W. Peter
Affiliation:
Departments of Biochemistry and Nutrition, and Physiology, University of New England, ArmidaleN.S.W. 2351, Australia
P. G. Board
Affiliation:
Departments of Biochemistry and Nutrition, and Physiology, University of New England, ArmidaleN.S.W. 2351, Australia
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Extract

Reduced glutathione (GSH) is synthesized within blood erythrocytes from the constituent nonessential amino acids, glutamic acid, cysteine and glycine. The concentration of GSH in. erythrocytes can therefore be affected by the permeability of erythrocyte membranes to certain of these amino acids and their availability within the erythrocyte (Young, Ellory & Tucker, 1976; Smith, 1977). Alterations in the activity of the two enzymes responsible for GSH synthesis, γ-glutamyl cysteine synthetase and glutathione synthetase can likewise influence GSH concentration (Smith, Lee & Mia, 1973; Blume, Paniker & Beutler, 1974; Wellner et al. 1974; Board, Morris & Peter, 1976).

Type
Short Notes
Information
The Journal of Agricultural Science , Volume 93 , Issue 1 , August 1979 , pp. 241 - 245
Copyright
Copyright © Cambridge University Press 1979

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