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Dietary phosphorus depletion in sheep: effects on plasma inorganic phosphorus, calcium, l,25-(OH)2-Vit.D3 and alkaline phosphatase and on gastrointestinal P and Ga balances

Published online by Cambridge University Press:  27 March 2009

G. Breves ,
R. Ross  and
H. Höller
G. Breves
Affiliation:
Department of Physiology, School of Veterinary Medicine, Hannover, Federal Republic of Germany
R. Ross
Affiliation:
Department of Animal Physiology and Nutrition, University of Leeds, Leeds
H. Höller
Affiliation:
Department of Physiology, School of Veterinary Medicine, Hannover, Federal Republic of Germany
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Summary

Experiments were carried out to study the effects of dietary P depletion on plasma concentrations of inorganic P (P1), calcium, 1,25-(OH)2-Vit.D3 and alkaline phosphatase, and to investigate the effects of P depletion, in comparison with P repletion, on intestinal flow and net disappearance of Ca and P in sheep. The animals were adapted to an experimental diet of pellets and chopped straw providing between 0·91 and 1·04 g P/day for depletion. They were repleted by single infusions of phosphate into the duodenum raising total P supply to about 4·1 g/day. During P depletion plasma P1, concentrations decreased significantly whereas those of Ca increased. The development of hypercalcaemia is discussed with respect to intestinal absorption and bone accretion and resorption. Plasma 1,25-(OH)2-Vit.D3 and alkaline phosphatase were not affected by P depletion.

In P depletion the flow through the gastrointestinal tract of total P contained in the digesta and faecal P excretion were significantly reduced and the P balance was slightly negative. Calcium net absorption from the gut was also reduced. Daily flow of total P and P1, contained in the particle-free intestinal fluid was markedly lower in P depletion as compared with P repletion. The percentage of net disappearance from the small intestines of total P and P1, in the particle-free fluid was 57 and 70 % in the depleted state and 79 and 93% in the repleted state.

Type
Research Article
Information
The Journal of Agricultural Science , Volume 105 , Issue 3 , December 1985 , pp. 623 - 629
Copyright
Copyright © Cambridge University Press 1985

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References

REFERENCES

Abdel Hafeez, H. M., Mañas-Almendros, M., Ross, R. & Care, A. D. (1982). Effects of dietary phosphorus and calcium on the intestinal absorption of Ca in sheep. British Journal of Nutrition 47, 69–77.CrossRefGoogle ScholarPubMed
Agricultural Research Council (1980). The Nutrient Requirements of Ruminant Livestock. Farnham Royal: Commonwealth Agricultural Bureaux.Google Scholar
Bar, A. & Wasserman, R. H. (1973). Control of calcium absorption and intestinal calcium binding protein synthesis. Biochemical and Biophysical Research Communications 54, 191–196.CrossRefGoogle ScholarPubMed
Ben-Ghedalia, D., Tagari, H., Zamwel, S. & Bondi, A. (1975). Solubility and net exchange of calcium, magnesium and phosphorus in digesta flowing along the gut of the sheep. British Journal of Nutrition 33, 87–94.CrossRefGoogle ScholarPubMed
Bessey, O. A., Lowry, O. H. & Brock, M. J. (1946). A method for the rapid determination of alkaline phosphatase with five cubic millimeters of serum. Journal of Biological Chemistry 164, 321–329.CrossRefGoogle ScholarPubMed
Breves, G. (1982). Plasma inorganic phosphorus and calcium concentrations in sheep with experimental phosphorus deficiency. Zentralblatt für Veterinärmedizin A 29, 716–719.CrossRefGoogle ScholarPubMed
Breves, G. & Höller, H. (1985). Effekte einer P-Depletion auf die gastrointestinalen Stickstoffumsetzungen bei Schafen. (Abstract). Zeitschrift für Tierphysiologie, Tierernährung und Futtermittelkunde 54, 63–64.Google Scholar
Clemens, T. L., Hendy, G. N., Graham, R. F., Baggioloni, E. G., Usko-Ković, M. R. & O'Rioedan, J. L. H. (1978). A radioimmunoassay for 1,25-dihydroxycholecalciferol. Clinical Science and Molecular Medicine 54, 329–332.Google Scholar
Clemens, T. L., Hendy, G. N., Papapoulos, S. E., Fraher, L. J., Care, A. D. & O'Riordan, J. L. H. (1979). Measurement of 1,25-dihydroxycholecalciferol in man by radioimmunoassay. Clinical Endocrinology 11, 225–234.CrossRefGoogle Scholar
Deutsche Landwirtschafts-Gesellschaft 1982. DLG-Futterwerttabellen für Wiederkäuer. Frankfurt: DLG-Verlag.Google Scholar
Faichney, G. J. (1975). The use of markers to partition digestion within the gastro-intestinal tract of ruminants. In Digestion and Metabolism in the Ruminant (ed. McDonald, I. W. and Warner, A. C. I.), pp. 277–291. Armidale, N. S. W., Australia: University of New England Publishing Unit.Google Scholar
Field, A. C, Suttle, N. F. & Nisbet, D. I. (1975). Effects of diets low in calcium and phosphorus on the development of growing lambs. Journal of Agricultural Science, Cambridge 85, 435–442.CrossRefGoogle Scholar
Fox, J., Pickard, D. W., Care, A. D. & Murray, T. M. (1978). Effect of low phosphorus diets on intestinal calcium absorption and the concentration of calcium binding protein in intact and parathyroidectomised pigs. Journal of Endocrinology 78, 379–385.CrossRefGoogle Scholar
Gericke, S. & Kurmies, B. (1952). Die kolorimetrische Phosphorsäurebestimmung mit Ammonium-Vanadat-Molybdat und ihre Anwendung bei der Pflanzenanalyse. Zeitschrift für Pflanzenernährung, Düngung und Bodenkunde 59, 325–347.Google Scholar
Grace, N. D., Davies, E. & Monro, J. (1977). Association of Mg, Ca, P and K with various fractions in the diet, digesta and faeces of sheep fed fresh pasture. New Zealand Journal of Agricultural Research 20, 441–448.CrossRefGoogle Scholar
Grace, N. D., Ulyatt, M. J. & MacRae, J. C. (1974). Quantitative digestion of fresh herbage by sheep. III. The movement of Mg, Ca, P, K and Na in the digestive tract. Journal of Agricultural Science, Cambridge 82, 321–330.CrossRefGoogle Scholar
Hughes, M. R., Brumbaugh, P. F., Haussler, M. R., Wergedal, J. E. & Baylink, D. J. (1975). Regulation of serum 1α,25-dihydroxyvitamin D3 by calcium and phosphate in the rat. Science 190, 578–580.CrossRefGoogle Scholar
Konitzer, K. (1958). Zur Bestimmung des Ca in kleinen Serummengen. Zeitschrift für Innere Medizin 13, 2–8.Google Scholar
Lessmann, H. W., Breves, G. & Holler, H. (1985). Effekte einer P-Depletion auf den Nettozuwachs an mikrobiell gebundenem Stickstoff im Pansen von Schafen. (Abstract.) Zeitschrift für Tierphysiologie, Tierernährung und Futtermittelkunde 54, 65.Google Scholar
Mañas-Almendros, M., Ross, R. & Care, A. D. (1982). Factors affecting the secretion of phosphate in parotid saliva in the sheep and goat. Quarterly Journal of Experimental Physiology 67, 269–280.CrossRefGoogle ScholarPubMed
Maunder, E. M. W., Pillay, A. V. & Care, A. D. (1985). Hypophosphataemia and vitamin D metabolism in sheep. Proceedings of the VI. Workshop on Vitamin D, p. 142. March 17–22, 1985, Merano, Italy.Google Scholar
Morrissey, R. L. & Wasserman, R. H. (1971). Calcium absorption and calcium binding protein in chicks on differing calcium and phosphorus intakes. American Journal of Physiology 220, 1509–1515.CrossRefGoogle ScholarPubMed
Pfeffer, E., Thompson, A. & Armstrong, D. G. (1970). Studies on intestinal digestion in the sheep. 3. Net movement of certain inorganic elements in the digestive tract on rations containing different proportions of hay and rolled barley. British Journal of Nutrition 24, 197–204.CrossRefGoogle ScholarPubMed
Richterich, R. (1968). Klinische Chemie, Theorie und Praxis, pp. 307–309. Basel, New York: S. Karger.Google Scholar
Scott, D., McLean, A. F. & Buchan, W. (1984). The effect of variation of phosphorus intake on net intestinal phosphorus absorption, salivary phosphorus secretion and pathway of excretion in sheep fed roughage diets. Quarterly Journal of Experimental Physiology 69, 439–452.CrossRefGoogle ScholarPubMed
Tanaka, Y. & De Luga, H. F. (1973). The control of 25-hydroxyvitamin D metabolism by inorganic phosphorus. Archives of Biochemistry and Biophysics 154, 566–574.CrossRefGoogle Scholar
Tomas, F. M., Moir, R. J. & Somers, M. (1967). Phosphorus turnover in sheep. Australian Journal of Agricultural Research 18, 635–645.CrossRefGoogle Scholar
Ulyatt, M. J. & Egan, A. R. (1979). Quantitative digestion of fresh herbage by sheep. V. The digestion of four herbages and prediction of sites of digestion. Journal of Agricultural Science, Cambridge 92, 605–616.CrossRefGoogle Scholar
Young, V. R., Richards, W. P., Lofgreen, G. P. & Luick, J. R. (1966). Phosphorus depletion in sheep and the ratio of calcium to phosphorus in the diet with reference to calcium and phosphorus absorption. British Journal of Nutrition 20, 783–794.CrossRefGoogle ScholarPubMed