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Online news media reporting of ketamine as a treatment for depression from 2000 to 2017

Published online by Cambridge University Press:  01 July 2021

Bronagh Gallagher
Affiliation:
Department of Psychiatry, Trinity College Dublin, St. Patrick’s University Hospital, James Street, Dublin 8, Ireland Trinity College Institute of Neuroscience, Trinity College Dublin, Dublin 2, Ireland
Aaron Neiman
Affiliation:
Department of Anthropology, Stanford University, Stanford, CA 94305, USA
Marie-Claire Slattery
Affiliation:
Department of Psychiatry, Trinity College Dublin, St. Patrick’s University Hospital, James Street, Dublin 8, Ireland
Declan M. McLoughlin*
Affiliation:
Department of Psychiatry, Trinity College Dublin, St. Patrick’s University Hospital, James Street, Dublin 8, Ireland Trinity College Institute of Neuroscience, Trinity College Dublin, Dublin 2, Ireland
*
*Address for correspondence: Declan M. McLoughlin, Department of Psychiatry, St. Patrick’s University Hospital, James Street, Dublin 8, Ireland. (Email: d.mcloughlin@tcd.ie)

Abstract

Objectives:

Since the first reporting of ketamine’s antidepressant effects in 2000, there has been growing public interest in this novel rapid-acting treatment for depression despite its abuse potential. Online media is an increasingly popular way for the general public to source information. Our objective was to examine how online news outlets have portrayed ketamine as an antidepressant by ascertaining the volume and content of relevant articles and trends over time.

Methods:

In this semi-quantitative study, we identified articles regarding ketamine’s use in depression from the 30 most popular English-language online news-generating sources over 18 years (2000–2017). Articles were then blindly assessed by 2 independent raters, who analysed the texts by quantifying the presence/absence of 12 content items.

Results:

We identified 97 articles, the number of which has increased since the first online news report in 2006. Most (69%) came from the USA and nearly all correctly stated the indications for ketamine. About half of the most recent articles mentioned abuse potential and 27% of articles referred to risks of unregulated use of ketamine. Just under 20% of articles referred to the lack of evidence regarding direct comparisons between ketamine and other currently available antidepressants. There was no difference in the overall level of detail within the articles during the study time period.

Conclusions:

Online news media articles have been generally positive about ketamine for treating depression but need to be interpreted with caution as many of them did not discuss negative aspects of ketamine and made unsubstantiated claims about ketamine.

Type
Original Research
Copyright
© The Author(s), 2021. Published by Cambridge University Press on behalf of The College of Psychiatrists of Ireland

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References

Andrade, C (2017). Ketamine for Depression, 4: In What Dose, at What Rate, by What Route, for How Long, and at What Frequency? Journal of Clinical Psychiatry 78, e852e857.CrossRefGoogle ScholarPubMed
Berman, RM, Cappiello, A, Anand, A, Oren, DA, Heninger, GR, Charney, DS, Krystal, JH (2000). Antidepressant effects of ketamine in depressed patients. Biological Psychiatry 47, 351354.CrossRefGoogle ScholarPubMed
Bokor, G, Anderson, PD (2014). Ketamine: an update on its abuse. Journal of Pharmacy Practice 27, 582586.CrossRefGoogle ScholarPubMed
Daly, EJ, Trivedi, MH, Janik, A, Li, H, Zhang, Y, Li, X, Lane, R, Lim, P, Duca, AR, Hough, D, Thase, ME, Zajecka, J, Winokur, A, Divacka, I, Fagiolini, A, Cubala, WJ, Bitter, I, Blier, P, Shelton, RC, Molero, P, Manji, H, Drevets, WC, Singh, JB (2019). Efficacy of Esketamine Nasal Spray Plus Oral Antidepressant Treatment for Relapse Prevention in Patients With Treatment-Resistant Depression: A Randomized Clinical Trial. JAMA Psychiatry 76, 893903.CrossRefGoogle ScholarPubMed
Fava, M, Freeman, MP, Flynn, M, Judge, H, Hoeppner, BB, Cusin, C, Ionescu, DF, Mathew, SJ, Cahng, LC, Iosifescu, DV, Murrough, J, Debattista, C, Schatzberg, AF, Trivedi, MH, Jha, MK, Sanacora, G, Wilkinson, St, Papakostas, GI (2018). Double-blind, placebo-controlled, dose-ranging trial of intravenous ketamine as adjunctive therapy in treatment-resistant depression (TRD). Molecular Psychiatry 25, 15921603.CrossRefGoogle Scholar
Forster, JA, Harrison, SC (2012). Ketamine uropathy: rising to the challenges of a new condition. BJU International 109, 12771278.CrossRefGoogle ScholarPubMed
Grunebaum, MF, Galfalvy, HC, Choo, TH, Keilp, JG, Moitra, VK, Parris, MS, Marver, JE, Burke, AK, MIlak, MS, Sublette, ME, Oquendo, MA, Mann, JJ (2018). Ketamine for Rapid Reduction of Suicidal Thoughts in Major Depression: A Midazolam-Controlled Randomized Clinical Trial. American Journal Psychiatry 175, 327335.CrossRefGoogle ScholarPubMed
Khorramzadeh, E, Lotfy, AO (1973). The use of ketamine in psychiatry. Psychosomatics 14, 344346.CrossRefGoogle Scholar
Kishimoto, T, Chawla, JM, Hagi, K, Zarate, CA, Kane, JM, Bauer, M, Correll, CU (2016). Single-dose infusion ketamine and non-ketamine N-methyl-d-aspartate receptor antagonists for unipolar and bipolar depression: a meta-analysis of efficacy, safety and time trajectories. Psycholofical Medicine 46, 14591472.CrossRefGoogle ScholarPubMed
Li, Q, Shi, L, Lu, G, Yu, HL, Yeung, FK, Wong, NK, Sun, L, Liu, K, Yew, D, Pan, F, Wang, DF, Sham, PC (2017). Chronic Ketamine Exposure Causes White Matter Microstructural Abnormalities in Adolescent Cynomolgus Monkeys. Frontiers in Neuroscience 11, 285.CrossRefGoogle ScholarPubMed
Loo, CK, Galvez, V, O’Keefe, E, Mitchell, PB, Hadzi-Pavlovic, D, Leyden, J, Harper, S, Somogyi, AA, Lai, R, Weickert, CS, Glue, P (2016). Placebo-controlled pilot trial testing dose titration and intravenous, intramuscular and subcutaneous routes for ketamine in depression. Acta Psychiatrica Scandinavica 134, 4856.CrossRefGoogle ScholarPubMed
Maeng, S, Zarate, CA Jr. (2007). The role of glutamate in mood disorders: results from the ketamine in major depression study and the presumed cellular mechanism underlying its antidepressant effects. Current Psychiatry Reports 9, 467474.CrossRefGoogle ScholarPubMed
NICE (NationalInstitute For Health And Care Excellence) (2020) Esketamine for treatment-resistant depression (ID1414). https://www.nice.org.uk/guidance/indevelopment/gid-ta10371. Google Scholar
Nickerson, JW, Attaran, A (2015). The Commission on Narcotic Drugs’ attempt to restrict ketamine. Lancet 385, e19.CrossRefGoogle ScholarPubMed
Sanacora, G, Frye, MA, McDonald, W, Mathew, SJ, turner, MS, Schatzberg, AF, Summergrad, P, Nemeroff, CB, American Psychiatric Association Council of Research Task Force on Novel Biomarkers and Treatments (2017). A Consensus Statement on the Use of Ketamine in the Treatment of Mood Disorders. JAMA Psychiatry 74, 399405.CrossRefGoogle ScholarPubMed
Schatzberg, AF (2019). A Word to the Wise About Intranasal Esketamine. American Journal of Psychiatry 176, 422424.CrossRefGoogle ScholarPubMed
Short, B, Fong, J, Galvez, V, Shelker, W, Loo, CK (2018). Side-effects associated with ketamine use in depression: a systematic review. Lancet Psychiatry 5, 6578.CrossRefGoogle ScholarPubMed
Singh, I, Morgan, C, Curran, V, Nutt, D, Schlag, A, McShane, R (2017). Ketamine treatment for depression: opportunities for clinical innovation and ethical foresight. Lancet Psychiatry 4, 419426.CrossRefGoogle ScholarPubMed
Singh, JB, Fedgchin, M, Daly, EJ, De Boer, P, Cooper, K, Murrough, JW, Sanacora, G, Shelton, RC, Kurian, B, Winokur, A, Fava, A, Manji, H, Drevets, WC, Van Neuten, L (2016). A Double-Blind, Randomized, Placebo-Controlled, Dose-Frequency Study of Intravenous Ketamine in Patients With Treatment-Resistant Depression. American Journal of Psychiatry 173, 816826.CrossRefGoogle ScholarPubMed
Tsai, TH, Cha, TL, Lin, CM, Tsao, CW, Tang, SH, Chuang, FP, Wu, ST, Sun, GH, Yu, DS, Chang, SY (2009). Ketamine-associated bladder dysfunction. International Journal of Urology 16, 826829.CrossRefGoogle ScholarPubMed
Tweed, WA, Minuck, M, Mymin, D (1972). Circulatory responses to ketamine anesthesia. Anesthesiology 37, 613619.CrossRefGoogle ScholarPubMed
Westlund, O, Färdigh, MA (2015). Accessing the news in an age of mobile media: tracing displacing and complementary effects of mobile news on newspapers and online news. Mobile Media & Communication 3, 5374.CrossRefGoogle Scholar
Wilkinson, ST, Ballard, ED, Bloch, MH, Mathew, SJ, Murrough, JW, Feder, A, Sos, P, Wang, G, Zarate, CA, Sanacora, G (2018). The Effect of a Single Dose of Intravenous Ketamine on Suicidal Ideation: A Systematic Review and Individual Participant Data Meta-Analysis. American Journal of Psychiatry 175, 150158.CrossRefGoogle ScholarPubMed
Williams, NR, Heifets, BD, Blasey, C, Sudheimer, K, Pannu, J, Pankow, H, Hawkins, J, Birnbaum, J, Lyons, DM, Rodriguez, CI, Schatzberg, AF (2018). Attenuation of Antidepressant Effects of Ketamine by Opioid Receptor Antagonism. American Journal of Psychiatry 175, 12051215.CrossRefGoogle ScholarPubMed
Winstock, AR, Mitcheson, L, Gillatt, DA, Cottrell, AM (2012). The prevalence and natural history of urinary symptoms among recreational ketamine users. BJU International 110, 17621766.CrossRefGoogle ScholarPubMed
Zanos, P, Thompson, SM, Duman, RS, Zarate, CA, Gould, TD (2018). Convergent Mechanisms Underlying Rapid Antidepressant Action. CNS Drugs 32, 197227.CrossRefGoogle ScholarPubMed
Zarate, CA Jr, Singh, JB, Carlson, PJ, Brutsche, NE, Ameli, R, Luckenbaugh, DA, Charney, DS, Manji, HK (2006). A randomized trial of an N-methyl-D-aspartate antagonist in treatment-resistant major depression. Archives of General Psychiatry 63, 856864.CrossRefGoogle ScholarPubMed
Zhang, MW, Hong, YX, Husain, SF, Harris, KM, Ho, R C (2017). Analysis of print news media framing of ketamine treatment in the United States and Canada from 2000 to 2015. PLoS One 12, e0173202.CrossRefGoogle ScholarPubMed

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