Hostname: page-component-77c89778f8-7drxs Total loading time: 0 Render date: 2024-07-20T08:38:36.734Z Has data issue: false hasContentIssue false

Does fluoxetine induce suicidal thoughts?

Published online by Cambridge University Press:  13 June 2014

Michael J Kelleher
Affiliation:
St. Anne's Hospital & Clinic, Shanakiel, Cork, Co. Cork, Ireland

Abstract

Reports from the United States have linked fluoxetine with suicidality. As a result, litigation is pending, and the matter has recieved much media attention. There is no acceptable evidence to support the hypothesis that fluoxetine promotes suicide.

Type
Perspective
Copyright
Copyright © Cambridge University Press 1994

Access options

Get access to the full version of this content by using one of the access options below. (Log in options will check for institutional or personal access. Content may require purchase if you do not have access.)

References

1.Asberg, M, Traskman, L, Thoren, P. 5HIAA in cerebrospinal fluid: a biochemical suicide predictor. Arch Gen Psychiatry 1976; 33: 93–7.CrossRefGoogle ScholarPubMed
2. Anon. Serotonin, suicidal behaviour and impulsivity. Lancet 1987; 2: 949–50.Google Scholar
3.Teicher, MH, Glod, C, Cole, JO. Emergency of intense suicidal preoccupation during fluoxetine treatment. Am J Psychiatry 1990; 147: 207–10.Google ScholarPubMed
4.Rothschild Anthony, J, Locke Carol, A. Re-exposure to fluoxetine after serious suicide attempts by three patients: the role of akathisia. J Clin Psychiatry 1991; 52: 491–3.Google Scholar
5.Lipinski, JF, Mallaya, G, Zimmerman, P. Fluoxetine induced akathisia, clinical and theoretical implications. J Clin Psychiatry 1989; 50: 339–42.Google ScholarPubMed
6.Dasgupta, K. 1990. Additional cases of suicidal ideation associated with fluoxetine. Am J Psychiatry 147; 11: 1570.CrossRefGoogle Scholar
7.King, RA, Riddle, MA, Chappell, PB, Hardin, MT, Anderson, GM, Lombroso, P, Schaill, L. Emergence of self-destructive phenomenon in children and adolescents during fluoxetine treatment. J Am Acad Child Adolesc Psychiatry 1991; 30(2): 179–86..CrossRefGoogle Scholar
8.Mann, JJ, Goodwin, FK, O'Brien, C, Robinson, DS. Suicidal behaviour and psychotropic medication. Consensus statement by the ACNP Council, 03 2nd 1992.Google Scholar
9.Beasley, CM, Dornseif, BE, Bosomworth, JC. Fluoxetine and suicide – a meta-analysis of controlled trials of treatment for depression. BMJ 1991; 303: 685–92.CrossRefGoogle ScholarPubMed
10.USA FDA Panel on Prozac. Effect on litigation. Scrip 1991; 1656: 21.Google Scholar
11.Regier, DA, Farmer, ME, Rae, DS, Locke, BZ, Keith, SJ, Judd, LL, Goodwin, FK. Comorbidity of mental disorders with alcohol and other drug abuse. JAMA 1990; 264; (19): 2511–8.CrossRefGoogle ScholarPubMed
12.Kroef, . Reactions to triazolam (Halcion) [Letter], Lancet 1979; 09.Google Scholar
13.Damluji, NF, Ferguson, JM. Paradoxical worsening of depressive symptomatology caused by antidepressants. J Clin Psychopharmacol 1988; 8: 342–9.CrossRefGoogle ScholarPubMed
14.Brent, DA, Kupper, DJ, Bromet, EJ, Dew, MA. The assessment and treatment of patients at risk from suicide. Psychiatry Update: vol 7. Washington DC: APP, 1988: 353–85.Google Scholar
15.Hagnel, Oet al.Suicide rates in the Ludby study: mental illness as a factor in suicide. Neuropsychobiol 1981; 7: 248–53.CrossRefGoogle Scholar
16.Guze, SB, Robins, E. Suicide and primary affective disorders. Br J Psychiatry 1970; 117: 437–48.CrossRefGoogle ScholarPubMed