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P153: The CIMA-Q and CompAS cohort studies on factors associated with Alzheimer's disease (AD): Exploring sociodemographic, health and neuropsychological profile of Subjective Cognitive Decline (SCD) participants from two culturally differentiated samples.

Published online by Cambridge University Press:  02 February 2024

Sonali Arora ,
Campos-Magdaleno Maria ,
Fátima Fernández-Feijoo ,
Alba Felpete ,
Samira Mellah ,
Sylvie Bellevile ,
Onésimo Juncos ,
Arturo X Pereiro  and
CIMA-Q
Sonali Arora
Affiliation:
University of Santiago de Compostela, Santiago de Compostela, Spain
Campos-Magdaleno Maria
Affiliation:
University of Santiago de Compostela, Santiago de Compostela, Spain
Fátima Fernández-Feijoo
Affiliation:
University of Santiago de Compostela, Santiago de Compostela, Spain
Alba Felpete
Affiliation:
University of Santiago de Compostela, Santiago de Compostela, Spain
Samira Mellah
Affiliation:
Centre de Recherche Institut universitaire de gériatrie de Montréal (IUGM), Université de Montréal, Canada
Sylvie Bellevile
Affiliation:
Centre de Recherche Institut universitaire de gériatrie de Montréal (IUGM), Université de Montréal, Canada
Onésimo Juncos
Affiliation:
University of Santiago de Compostela, Santiago de Compostela, Spain
Arturo X Pereiro
Affiliation:
University of Santiago de Compostela, Santiago de Compostela, Spain
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Abstract

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Objective:

To explore commonalities and differences in the sociodemographic, health, and neuropsychological characteristics of participants with SCD recruited in two culturally differentiated cohort studies, namely CIMA-Q (Canada; Bellevile et al., 2019) and CompAS (Spain; Juncos et al., 2012).

Methods:

Older adults with subjective cognitive complaints of the CompAS (N=251; 68.92% women; Control: 30.3%; SCD: 25.9%; MCI: 28.7%) and the CIMA-Q (N=179; 71.5% women; Control:16.1%; SCD: 36.8%; MCI:28.6%) were recruited, respectively, from primary care centers and memory clinics, excluding patients with dementia and other neurological or psychiatric disturbances. Cognitive complaints were assessed considering coincident items of the QAM and MFE questionnaires. Cut-off points for the 5%ile were calculated independently in both samples and according to this, participants were classified as SCD or controls (CompAS: N= 141; CIMA-Q: N=161) considering complaints relevance at baseline (Pereiro et al., 2021). Participants underwent neuropsychological assessment. Participants diagnosed as Mild Cognitive Impairment (MCI) were excluded from the analysis. Between cohort-studies and inter-group (control, SCD) differences were tested in the sociodemographic, health and neuropsychological measures considered. The Holm-Bonferroni correction was applied to reduce the probability of type I error (p<.003).

Results:

Identical cut-off points for 5%ile were obtained in both samples though SCD prevalence was slightly higher in CIMA-Q. For both samples, equivalence between Control and SCD participants in sociodemographic, health, functionality, and neuropsychological measures was observed. Only complaints and depressive symptomatology was significantly higher in SCD participants than in controls in both CompAS and CIMA-Q studies.

Participants of the CIMA-Q, Controls and SCD, showed significantly higher age, cognitive reserve proxies, comorbidity, and better attentional performance than the CompAS participants (see Table 1). CompAS participants, Controls and SCD, showed more neuropsychiatric symptomatology than CIMA-Q participants (see Table 1).

Conclusions:

Control and SCD participants showed equivalence on sociodemographic, health, functional, and neuropsychological measures in both studies. However, significant between-sample differences in the two groups, particularly in SCD participants, were observed in sociodemographic, health, cognitive reserve, behavioral and attentional measures. Identification of these factors are critical to analyze the transcultural validity of cognitive complaints in predicting progression to AD.

Table 1

Between group (control, SCD) and Between study (CIMA-Q, CompAS) differences in sociodemographic, health, and cognitive measures

CIMA-QCompASBetween-studies differences
Between-group differencesBetween-group differencesControlSCD
Sociodemographics
AgeNSNSCIMA-Q>CompAS; F(1,124)=22.78; p<.001CIMA-Q>CompAS; F(1,172)=36.97; p<.001
GenderNSNSNSNS
Schooling (years)NSNSNSCIMA-Q>CompAS; F(1,172)=20.74; p<.001
Prof. qualificationNSNSCIMA-Q>CompAS; χ24=18.18; p=001CIMA-Q>CompAS; χ24=33.95; p<001
Cognitive reserve (quartiles)NSNSCIMA-Q>CompAS; χ23=13.57; p=004CIMA-Q>CompAS;χ23==42.56; p<001
Memory familiar antecedentsNSNSNSCIMA-Q>CompAS; χ21==15.03; p<001
Neuropsychology
Subjective complaints*SCD>Control; F(1,119)=147.17, p<.001)SCD>Control; F(1,177)=192.87, p<.001NSNS
Charlson Index*SCD>Control; F(1,115)=5.29, p=.023NSCIMA-Q>CompAS; F(1,123)=394.96; p<.001CIMA-Q>CompAS; F(1,168)=335.98; p<.001
General cognitionNS (MoCA)NS (CAMCOG-R)----
GDS-15*SCD>Control; F(1,119)=8.60, p=.004SCD>Control; F(1,176)=11.97, p<.001NSNS
TMT-A (secs.)*NSNSNSNS
TMT-B (secs.)*NSNSCompAS>CIMA-Q; F(1,118)=12.56; p<.001CompAS>CIMA-Q; F(1,163)=21.74; p<.001
Verbal fluencyNSNSNSNS
Semantic fluencyNSNSNSNS
Boston testNSNSNSNS
NPI-QNSNSCompAS>CIMA-Q; F(1,119)=16.68; p<.001CompAS> CIMA-Q; F(1,162)=24.46; p<.001
Immediate recall (RAVL test)NSNSNSNS
Short delay (RAVL test)NSNSNSNS
Long delay(RAVL test)NSNSNSNS
Intrusions (RAVL test)NSNSNSNS
IAVD*NSNSNSNS

Note: *On these measures, higher scores denote worse cognition or health condition. TMT: Trail Making Test (A and B forms); NPI-Q: Neuropsychiatric Inventory-Questionnaire; RAVL: Rey Auditory Verbal Learning; IAVD: Instrumental Activity of Daily Living.

Type
Posters
Information
International Psychogeriatrics , Volume 35 , Issue S1 , December 2023 , pp. 269 - 272
Copyright
© International Psychogeriatric Association 2024

Footnotes

∗

Some of the data used in the preparation of this proposal were obtained from the sample of the Consortium for the early identification of Alzheimer's disease - Québec (CIMA-Q; cima-q.ca). The CIMA-Q researchers contributed to the establishment of protocols, the implementation of the cohort, the ; obtaining of clinical, cognitive and neuroimaging data as well as the sequence of biological samples. A list of the researchers involved in the conception of CIMA-Q can be found on the website cima-q.ca

References

References:

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Juncos-Rabadan, O., Pereiro, A.X., Facal, D., Rodriguez, N., Lojo, C., Caamaño, J.A., Sueiro, J., Boveda, J., & Eiroa, P. (2012). Prevalence and correlates of cognitive impairment in adults with subjective memory complaints in primary care centres. Dement Geriatr Cogn Disord. ;33(4), 226–232. https://doi.org/10.1159/000338607.CrossRefGoogle ScholarPubMed
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