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P103: Middle Cerebral Artery Stenosis is Associated with Severity of Depression in Elderly Patients: Magnetic Resonance Angiography (MRA) Findings

Published online by Cambridge University Press:  02 February 2024

Kim Seung Woo
Affiliation:
Department of Psychiatry, Depression Center, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea
Min Kang Lee
Affiliation:
Department of Psychiatry, Depression Center, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea
Hyewon Kim
Affiliation:
Department of Psychiatry, Hanyang University Medical Center, Seoul, South Korea
Mi Jin Park
Affiliation:
Department of Psychiatry, Depression Center, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea
Maurizio Fava
Affiliation:
Depression Clinical and Research Program, Massachusetts General Hospital, Harvard Medical School, Boston, USA
David Mischoulon
Affiliation:
Depression Clinical and Research Program, Massachusetts General Hospital, Harvard Medical School, Boston, USA
Hong-Jin Jeon*
Affiliation:
Department of Psychiatry, Depression Center, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea Department of Health Sciences & Technology, Department of Medical Device Management & Research, and Department of Clinical Research Design & Evaluation, Samsung Advanced Institute for Health Sciences & Technology (SAIHST), Sungkyunkwan University, Seoul, Korea
*
Corresponding author Hong Jin Jeon, M.D., Ph.D. Professor, Department of Psychiatry, Depression Center, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea, Director of the Digital Therapeutics Research Center, Samsung Medical Center, Department of Health Sciences & Technology, Department of Medical Device Management & Research, and Department of Clinical Research Design & Evaluation, Samsung Advanced Institute for Health Sciences & Technology (SAIHST), Sungkyunkwan University, Seoul, Korea
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Abstract

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Objective:

Vascular abnormalities have been frequently reported in elderly adults as a potential risk factor of late-life depression. However, it is still unclear whether stenosis of cerebral arteries may increase risk of depression in the elderly.

Methods:

Study participants were 365 patients 65 years or older with depressive disorder who had undergone brain MRI and angiography (MRA) which were assessed by trained radiologists, and the 15-item Geriatric Depression Scale (GDS-15) and the Mini Mental State Examination (MMSE), and blood glucose and lipid profiles.

Results:

Of the 365 subjects, 108 had at least one location of cerebral artery stenosis (29.59%). Stenosis was associated with age, marital status, infarction, and atherosclerosis. In multivariable linear regression analysis of different locations of stenosis among the whole sample, only bilateral middle cerebral artery (MCA) stenosis was found to have a significant association with higher GDS-15 score (p= 0.0138), and more than 8 scores in the GDS-15 (p= 0.0045), but no significant associations with ACA (anterior cerebral artery), PCA (posterior cerebral artery) or ICA (internal carotid artery). In multivariable linear logistic analysis of different locations among patients with at least one cerebral artery stenosis, left MCA was found to be significantly related to higher GDS-15 scores but not with right MCA (p = 0.0202).

Conclusion:

MCA stenosis is significantly associated with severity of depression in elderly adults with cerebral artery stenosis, especially in those with left MCA stenosis.

Key points

  • Patients with cerebral artery stenosis found with brain magnetic resonance angiography (MRA) were associated with higher depression severity.

  • Stenosis of both left and right middle cerebral artery (MCA) was associated with greater depression severity, with left MCA stenosis having a greater influence on depression severity than right MCA stenosis.

  • Higher depression severity in patients with MCA stenosis suggests that depression in elderly patients is mediated at least in part by vascular pathology of MCA supplied regions and careful investigation and management of cerebral artery stenosis and their risk factors may help reduce the severity of depression in elderly patients who visit psychiatrists.

Type
Posters
Copyright
© International Psychogeriatric Association 2024

Footnotes

#81 Irwon-ro, Gangnam-gu, Seoul, South Korea, 135-710

All authors agreed to this submission.

The material is original research, has not been previously published, and has not been submitted for publication elsewhere while under consideration. The data has not been previously presented orally or by poster at scientific meetings.