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No evidence in favor of a more deleterious impact of a major depressive episode on verbal memory in older patients with antidepressant response

Published online by Cambridge University Press:  26 February 2015

Elise Blandin ,
Guilhem Carle ,
Benoit Theuil ,
Julien Katz  and
Philip Gorwood
Elise Blandin
Affiliation:
CMME (Groupe Hospitalier Sainte-Anne), Université Paris Descartes, Paris, France Centre of Psychiatry and Neurosciences, INSERM U894, Paris 75014, France
Guilhem Carle
Affiliation:
Secteur 17 Centre Hospitalier Sainte-Anne, 23 rue Broussais 75014 Paris, France
Benoit Theuil
Affiliation:
SHU (Groupe Hospitalier Sainte-Anne), 7 rue Cabanis, 75014 Paris, France
Julien Katz
Affiliation:
AP-HP Hôpital H. Mondor-A. Chenevier, Pôle de Psychiatrie, Créteil 94000 Paris, France
Philip Gorwood*
Affiliation:
CMME (Groupe Hospitalier Sainte-Anne), Université Paris Descartes, Paris, France Centre of Psychiatry and Neurosciences, INSERM U894, Paris 75014, France
*
Correspondence should be addressed to: Pr Philip Gorwood, CMME (Sainte-Anne hospital) 100 rue de la Santé, 75014 Paris, France. Phone: +33 1 45 65 8369. Email: p.gorwood@ch-sainte-anne.fr.
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Abstract

Background:

Older patients may be more vulnerable to the deleterious effect of depressive episodes on delayed narrative memory, a cognitive task which reflects hippocampal activity. We aimed to disentangle which factors could explain such increased vulnerability in the elderly, including the poorer response to treatment, a longer lifetime exposure to past depressive episodes, and lower baseline memory skills.

Methods:

From an initial sample of 8,229 depressed outpatients, we focused on the 2,424 treatment responders, and compared older (65 years old and over, N = 233) to younger (N = 2,191) ones. These patients were included through general practitioners’ assessment and tested for the Wechsler delayed paragraph recall index, a valid and sensitive test assessing verbal declarative memory (and a marker of the hippocampal function), at baseline and after six weeks of treatment.

Results:

As expected, older patients after response to antidepressants showed decreased narrative memory abilities compared to younger ones. As baseline memory performance and residual depressive symptoms were also found in excess in this sample, they could act as confounders. Indeed, after controlling for these two factors, the role of age in memory performance after treatment response was ruled out.

Conclusions:

The potential “toxicity” of a depressive episode to cognitive functions related to the hippocampus may not be more critical in older patients compared to younger ones. Limiting remaining depressive symptoms in older depressed patients might be a way to counteract the observed worsening of memory functions in depressed patients.

Keywords

depressive episodesmemory impairmentelderly patientsneurotoxicityagelifetime
Type
Research Article
Information
International Psychogeriatrics , Volume 27 , Issue 9 , September 2015 , pp. 1477 - 1484
Copyright
Copyright © International Psychogeriatric Association 2015 

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References

Arnone, D., McIntosh, A. M., Ebmeier, K. P., Munafo, M. R. and Anderson, I. M. (2012). Magnetic resonance imaging studies in unipolar depression: systematic review and meta-regression analyses. European Neuropsychopharmacology, 22, 1–16. doi:10.1016/j.euroneuro.2011.05.003.CrossRefGoogle ScholarPubMed
Arnone, D., McKie, S. and Elliott, R. (2013). State-dependent changes in hippocampal grey matter in depression. Molecular Psychiatry, 18, 1265–1272. doi: 10.1038.CrossRefGoogle ScholarPubMed
Banasr, M. and Duman, R. S. (2007). Regulation of neurogenesis and gliogenesis by stress and antidepressant treatment. CNS & Neurological Disorders - Drug Targets, 6, 311–320.CrossRefGoogle ScholarPubMed
Bora, E., Harrison, B. J., Yücel, M. and Pantelis, C. (2012). Cognitive impairment in euthymic major depressive disorder: a meta-analysis. Psychological Medicine, 26, 1–10.Google Scholar
Bornstein, R. A. and Chelune, G. J. (1989). Factor structure of the Wechsler memory scale-revised in relation to age and educational level. Archives of Clinical Neuropsychology, 4, 15–24.CrossRefGoogle ScholarPubMed
Butters, M. A. et al. (2000). Changes in cognitive functioning following treatment of late-life depression. The American Journal of Psychiatry, 157, 1949–1954.CrossRefGoogle ScholarPubMed
Campbell, S., Marriott, M., Nahmias, C. and MacQueen, G. M. (2004). Lower hippocampal volume in patients suffering from depression: a meta-analysis. The American Journal of Psychiatry, 161, 598–607.CrossRefGoogle ScholarPubMed
Chen, P., Ganguli, M., Mulsant, B. H. and DeKosky, S. T. (1999). The temporal relationship between depressive symptoms and dementia: a community-based prospective study. Archives of General Psychiatry, 56, 261–266.CrossRefGoogle ScholarPubMed
Dotson, V. M., Beydoun, M. A. and Zonderman, A. B. (2010). Recurrent depressive symptoms and the incidence of dementia and mild cognitive impairment. Neurology, 6, 27–34.CrossRefGoogle Scholar
Gorwood, P., Corruble, E., Falissard, B. and Goodwin, G. M. (2008). Toxic effects of depression on brain function: impairment of delayed recall and the cumulative length of depressive disorder in a large sample of depressed outpatients. The American Journal of Psychiatry, 165, 731–739. doi:10.1176/appi.ajp.2008.07040574.CrossRefGoogle Scholar
Gorwood, P., Weiller, E., Lemming, O. and Katona, C. (2007). Escitalopram prevents relapse in older patients with major depressive disorder. The American Journal of Geriatric Psychiatry, 15, 581–593. doi:10.1097/01.JGP.0000240823.94522.4c.CrossRefGoogle ScholarPubMed
Gorwood, P., Richard-Devantoy, S., Baylé, F. and Cléry-Melun, M. L. (2014). Psychomotor retardation is a scar of past depressive episodes, revealed by simple cognitive tests. European Neuropsychopharmacology, 24, 1630–1640. doi:10.1016/j.euroneuro.2014.07.013. CrossRefGoogle ScholarPubMed
Green, R. C. et al. (2003). Depression as a risk factor for Alzheimer disease: the MIRAGE Study. Archives of Neurology, 60, 753–759.CrossRefGoogle ScholarPubMed
Halvorsen, M., Waterloo, K., Sundet, K., Eisemann, M. and Wang, C. E. (2011). Verbal learning and memory in depression: a 9-year follow-up study. Psychiatry Research, 15, 350–354.CrossRefGoogle Scholar
IBM Corp. (2013). IBM SPSS Statistics for MacIntosh, Version 22.0. Armonk, NY: IBM Corp. Google Scholar
Kessing, L. V. (2012). Depression and the risk for dementia. Current Opinion in Psychiatry, 25, 457–461. doi:10.1097/YCO.0b013e328356c368.CrossRefGoogle ScholarPubMed
Lim, J. et al. (2013). Sensitivity of cognitive tests in four cognitive domains in discriminating MDD patients from healthy controls: a meta-analysis. International Psychogeriatrics, 25, 1543–1557.CrossRefGoogle ScholarPubMed
Luppa, M., Luck, T., Ritschel, F., Angermeyer, M.C., Villringer, A. and Riedel-Heller, S. G. (2013). Depression and incident dementia. An 8-year population-based prospective study. PLoS One, 8, e59246.CrossRefGoogle ScholarPubMed
Maeshima, H. et al. (2012). Residual memory dysfunction in recurrent major depressive disorder–a longitudinal study from Juntendo University Mood Disorder Project. Journal of Affective Disorders, 143, 84–88. doi:10.1016/j.jad.2012.05.033.CrossRefGoogle ScholarPubMed
Maeshima, H. et al. (2013). Time course for memory dysfunction in early-life and late-life major depression: a longitudinal study from the Juntendo University Mood Disorder Project. Journal of Affective Disorders, 151, 66–70.CrossRefGoogle ScholarPubMed
Nordanskog, P., Dahlstrand, U., Larsson, M. R., Larsson, E. M., Knutsson, L. and Johanson, A. (2010). Increase in hippocampal volume after electroconvulsive therapy in patients with depression: a volumetric magnetic resonance imaging study. The Journal of ECT, 26, 62–67.CrossRefGoogle ScholarPubMed
O’Brien, J. T., Lloyd, A., McKeith, I., Gholkar, A. and Ferrier, N. (2004). A longitudinal study of hippocampal volume, cortisol levels, and cognition in older depressed subjects. The American Journal of Psychiatry, 161, 2081–2090.CrossRefGoogle ScholarPubMed
Paradiso, S., Lamberty, G. J., Garvey, M. J. and Robinson, R. G. (1997). Cognitive impairment in the euthymic phase of chronic unipolar depression. The Journal of Nervous and Mental Disease, 185, 748–754.CrossRefGoogle ScholarPubMed
Rajkowska, G. (2000). Postmortem studies in mood disorders indicate altered numbers of neurons and glial cells. Biological Psychiatry, 48, 766–777.CrossRefGoogle ScholarPubMed
Reynolds, C. F. 3rd., Frank, E. and Kupfer, D. J. (1996). Treatment outcome in recurrent major depression: a post hoc comparison of elderly (“young old”) and midlife patients. The American Journal of Psychiatry, 153, 1288–1292.Google ScholarPubMed
Russel, E. W. (1973). A multiple scoring method for the assessment of complex memory functions. Journal of Consulting and Clinical Psychology; 43, 800–809.CrossRefGoogle Scholar
Schacter, D. L., Alpert, N. M., Savage, C. R., Rauch, S. L. and Albert, M. S. (1996). Conscious recollection and the human hippocampal formation: evidence from positron emission tomography. Proceedings of the National Academy of Sciences, 93, 321–325.CrossRefGoogle ScholarPubMed
Sheline, Y. I., Sanghavi, M., Mintun, M. A. and Gado, M. H. (1999). Depression duration but not age predicts hippocampal volume loss in medically healthy women with recurrent major depression. The Journal of Neuroscience, 19, 5034–5043.CrossRefGoogle Scholar
Sheline, Y. I. et al. (2012). Treatment course with antidepressant therapy in late-life depression. The American Journal of Psychiatry, 169, 1185–1193.CrossRefGoogle ScholarPubMed
Snaith, R. P. and Zigmond, A. S. (1986). The hospital anxiety and depression scale. British medical journal (Clinical research ed.), 292, 344.CrossRefGoogle ScholarPubMed
Zou, K. et al. (2010). Changes of brain morphometry in first-episode, drug-naive, non-late-life adult patients with major depression: an optimized voxel-based morphometry study. Biological Psychiatry, 67, 186–188. doi:10.1016/j.biopsych.2009.09.014.CrossRefGoogle ScholarPubMed