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Neuroimaging of depression in Parkinson's disease: a review

Published online by Cambridge University Press:  02 September 2013

Marcos Hortes N. Chagas ,
Ila M.P. Linares ,
Giovana Jorge Garcia ,
Jaime E.C. Hallak ,
Vitor Tumas  and
José Alexandre S. Crippa
Marcos Hortes N. Chagas*
Affiliation:
Department of Neuroscience and Behavior, Ribeirão Preto Medical School, University of São Paulo, and INCT Translational Medicine (CNPq), São Paulo, Brazil
Ila M.P. Linares
Affiliation:
Department of Neuroscience and Behavior, Ribeirão Preto Medical School, University of São Paulo, and INCT Translational Medicine (CNPq), São Paulo, Brazil
Giovana Jorge Garcia
Affiliation:
Department of Neuroscience and Behavior, Ribeirão Preto Medical School, University of São Paulo, and INCT Translational Medicine (CNPq), São Paulo, Brazil
Jaime E.C. Hallak
Affiliation:
Department of Neuroscience and Behavior, Ribeirão Preto Medical School, University of São Paulo, and INCT Translational Medicine (CNPq), São Paulo, Brazil
Vitor Tumas
Affiliation:
Department of Neuroscience and Behavior, Ribeirão Preto Medical School, University of São Paulo, and INCT Translational Medicine (CNPq), São Paulo, Brazil
José Alexandre S. Crippa
Affiliation:
Department of Neuroscience and Behavior, Ribeirão Preto Medical School, University of São Paulo, and INCT Translational Medicine (CNPq), São Paulo, Brazil
*
Correspondence should be addressed to: Marcos Hortes N. Chagas, Hospital das Clínicas, Terceiro Andar, Av. Bandeirantes, 3900, 14048-900-Ribeirão Preto, SP, Brazil. Phone: +55-16-360227031; Fax: +55-16-36022544. Email: mchagas@fmrp.usp.br.
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Abstract

Background:

Depression is the most common psychiatric manifestation in patients with Parkinson's disease (PD). In addition, depressive symptoms may be considered to be a prodromal manifestation of PD. In recent years, the association between PD and depression has been the focus of neuroimaging studies using functional and structural techniques.

Methods:

The aim of this study was to review the main neuroimaging studies assessing the comorbidity between depression and PD. Literature searches were conducted to find the major neuroimaging studies that consider primarily the comorbidity between depression and PD using the indices Web of Science and Lilacs.

Results:

In total, 296 papers were identified, and 18 of these studies were selected for the current review. The principal neuroimaging technique used was SPECT. The structural neuroimaging studies that have evaluated the impact of current or previous bouts of depression on the neurodegenerative process of PD are scarce and inclusive. The instruments that were used to evaluate depression differed among the studies. Several brain regions appear to be involved in depression, particularly the limbic system and the basal ganglia. In addition, the serotonergic, dopaminergic, and noradrenergic systems also appear to be associated with depressive symptoms in PD.

Conclusion:

Several brain regions and neurotransmitter systems are involved in depression in PD; however, the variety of criteria used to evaluate depressive symptoms precludes more specific conclusions.

Keywords

neuroimagingParkinson’s diseasedepression
Type
Review Article
Information
International Psychogeriatrics , Volume 25 , Issue 12 , December 2013 , pp. 1953 - 1961
Copyright
Copyright © International Psychogeriatric Association 2013 

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