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Autobiographical narratives relate to Alzheimer's disease biomarkers in older adults

Published online by Cambridge University Press:  27 June 2014

Rachel F. Buckley ,
Michael M. Saling ,
Muireann Irish ,
David Ames ,
Christopher C. Rowe ,
Victor L. Villemagne ,
Nicola T. Lautenschlager ,
Paul Maruff ,
S. Lance Macaulay  and
Ralph N. Martins
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Rachel F. Buckley*
Affiliation:
Melbourne School of Psychological Sciences, University of Melbourne, Melbourne, Victoria, Australia The Florey Institute of Neuroscience and Mental Health, University of Melbourne, Melbourne, Victoria, Australia
Michael M. Saling
Affiliation:
Melbourne School of Psychological Sciences, University of Melbourne, Melbourne, Victoria, Australia The Florey Institute of Neuroscience and Mental Health, University of Melbourne, Melbourne, Victoria, Australia
Muireann Irish
Affiliation:
Neuroscience Research Australia, Sydney, New South Wales, Australia School of Psychology, the University of New South Wales, Kensington, Sydney, New South Wales, Australia
David Ames
Affiliation:
National Aging Research Institute, Melbourne, Victoria, Australia The Academic Unit for Psychiatry of Old Age, St. Vincent's Hospital, Department of Psychiatry, University of Melbourne, Melbourne, Victoria, Australia
Christopher C. Rowe
Affiliation:
Department of Nuclear Medicine and Centre for PET, Austin Health, Heidelberg, Australia The Department of Medicine, Austin Health, University of Melbourne, Melbourne, Victoria, Australia
Victor L. Villemagne
Affiliation:
Department of Nuclear Medicine and Centre for PET, Austin Health, Heidelberg, Australia The Department of Medicine, Austin Health, University of Melbourne, Melbourne, Victoria, Australia
Nicola T. Lautenschlager
Affiliation:
The Academic Unit for Psychiatry of Old Age, St. Vincent's Hospital, Department of Psychiatry, University of Melbourne, Melbourne, Victoria, Australia School of Psychiatry and Clinical Neurosciences and West Australian Centre for Health & Ageing, University of Western Australia, Crawley, Australia
Paul Maruff
Affiliation:
The Florey Institute of Neuroscience and Mental Health, University of Melbourne, Melbourne, Victoria, Australia Cogstate Ltd, Melbourne, Victoria, Australia
S. Lance Macaulay
Affiliation:
Commonwealth Scientific Industrial Research Organization, Melbourne, Victoria, Australia
Ralph N. Martins
Affiliation:
Centre of Excellence for Alzheimer's Disease Research and Care, School of Medical Sciences, Edith Cowan University, Perth, Western Australia, Australia Sir James McCusker Alzheimer's Disease Research Unit (Hollywood Private Hospital), Perth, Western Australia, Australia School of Psychiatry and Clinical Neurosciences, University of Western Australia, Perth, Western Australia, Australia
Cassandra Szoeke
Affiliation:
National Aging Research Institute, Melbourne, Victoria, Australia
Colin L. Masters
Affiliation:
The Florey Institute of Neuroscience and Mental Health, University of Melbourne, Melbourne, Victoria, Australia
Stephanie R. Rainey-Smith
Affiliation:
Centre of Excellence for Alzheimer's Disease Research and Care, School of Medical Sciences, Edith Cowan University, Perth, Western Australia, Australia Sir James McCusker Alzheimer's Disease Research Unit (Hollywood Private Hospital), Perth, Western Australia, Australia
Alan Rembach
Affiliation:
The Florey Institute of Neuroscience and Mental Health, University of Melbourne, Melbourne, Victoria, Australia
Greg Savage
Affiliation:
ARC Centre of Excellence in Cognition and its Disorders, Macquarie University, Sydney, New South Wales, Australia
Kathryn A. Ellis
Affiliation:
The Florey Institute of Neuroscience and Mental Health, University of Melbourne, Melbourne, Victoria, Australia The Academic Unit for Psychiatry of Old Age, St. Vincent's Hospital, Department of Psychiatry, University of Melbourne, Melbourne, Victoria, Australia
*
Correspondence should be addressed to: Rachel F. Buckley, BSc (Hons), Melbourne School of Psychological Sciences, Redmond Barry Building, University of Melbourne, Melbourne, Victoria 3010, Australia. Phone: +613-8344-4297; Fax: +613-9347-6618. Email: rachel.buckley@unimelb.edu.au.
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Abstract

Background:

Autobiographical memory (ABM), personal semantic memory (PSM), and autonoetic consciousness are affected in individuals with mild cognitive impairment (MCI) but their relationship with Alzheimer's disease (AD) biomarkers are unclear.

Methods:

Forty-five participants (healthy controls (HC) = 31, MCI = 14) completed the Episodic ABM Interview and a battery of memory tests. Thirty-one (HC = 22, MCI = 9) underwent β-amyloid positron emission tomography (PET) and magnetic resonance (MR) imaging. Fourteen participants (HC = 9, MCI = 5) underwent one imaging modality.

Results:

Unlike PSM, ABM differentiated between diagnostic categories but did not relate to AD biomarkers. Personal semantic memory was related to neocortical β-amyloid burden after adjusting for age and apolipoprotein E (APOE) ɛ4. Autonoetic consciousness was not associated with AD biomarkers, and was not impaired in MCI.

Conclusions:

Autobiographical memory was impaired in MCI participants but was not related to neocortical amyloid burden, suggesting that personal memory systems are impacted by differing disease mechanisms, rather than being uniformly underpinned by β-amyloid. Episodic and semantic ABM impairment represent an important AD prodrome.

Keywords

autobiographical memoryβ-amyloidhippocampal volumemild cognitive impairment
Type
Research Article
Information
International Psychogeriatrics , Volume 26 , Issue 10 , October 2014 , pp. 1737 - 1746
Copyright
Copyright © International Psychogeriatric Association 2014 

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References

Buckley, R. et al. (2013). Factors affecting subjective memory complaints in the AIBL aging study: biomarkers, memory, affect, and age. International Psychogeriatrics, 25, 1307–1315. doi:10.1017/S1041610213000665.CrossRefGoogle ScholarPubMed
Buckley, R. et al. (2014). Personal memory function in mild cognitive impairment (MCI) and subjective memory complaints: results from the Australian Imaging, Biomarkers, and Lifestyle (AIBL) Study of Ageing. Journal of Alzheimer's Disease, 40, 551–561.CrossRefGoogle ScholarPubMed
Conway, M. A. and Pleydell-Pearce, C. W. (2000). The construction of autobiographical memories in the self-memory system. Psychological Review, 107, 261–288. doi:10.1037//0033-295X.107.2.261.CrossRefGoogle ScholarPubMed
Ellis, K. et al. (2009). The Australian Imaging, Biomarkers and Lifestyle (AIBL) study of aging: methodology and baseline characteristics of 1112 individuals recruited for a longitudinal study of Alzheimer's disease. International Psychogeriatrics, 21, 672–687. doi:10.1017/S1041610209009405.CrossRefGoogle ScholarPubMed
Ellis, K. et al. (2014). Rates of diagnostic transition and cognitive change at 18-month follow-up among 1,112 participants in the Australian Imaging, Biomarkers and Lifestyle Flagship Study of Ageing (AIBL). International Psychogeriatrics, 26, 543–554. doi:10.1017/S1041610213001956.CrossRefGoogle Scholar
Fraser, L. M., O’Carroll, R. E. and Ebmeier, K. P. (2008). The effect of electroconvulsive therapy on autobiographical memory: a systematic review. The Journal of ECT, 24, 10–17. doi:10.1097/YCT.0b013e3181616c26.CrossRefGoogle ScholarPubMed
Gilboa, A., Ramirez, J., Köhler, S., Westmacott, R., Black, S. E. and Moscovitch, M. (2005). Retrieval of autobiographical memory in Alzheimer's disease: relation to volumes of medial temporal lobe and other structures. Hippocampus, 15, 535–550. doi:10.1002/hipo.20090.CrossRefGoogle ScholarPubMed
Gilboa, A., Winocur, G., Grady, C. L., Hevenor, S. J. and Moscovitch, M. (2004). Remembering our past: functional neuroanatomy of recollection of recent and very remote personal events. Cerebral Cortex, 14, 1214–1225. doi:10.1093/cercor/bhh082.CrossRefGoogle ScholarPubMed
Giorgio, A. et al. (2010). Age-related changes in grey and white matter structure throughout adulthood. Neuroimage, 51, 943–951. doi:10.1016/j.neuroimage.2010.03.004.CrossRefGoogle ScholarPubMed
Good, C. D., Johnsrude, I. S., Ashburner, J., Henson, R. N., Fristen, K. and Frackowiak, R. S. (2002). A voxel-based morphometric study of ageing in 465 normal adult human brains. 5th IEEE EMBS International Summer School on Biomedical Imaging. doi:10.1109/SSBI.2002.1233974.CrossRefGoogle Scholar
Hou, C. E., Miller, B. L. and Kramer, J. H. (2005). Patterns of autobiographical memory loss in dementia. International Journal of Geriatric Psychiatry, 20, 809–815. doi:10.1002/gps.1361.CrossRefGoogle ScholarPubMed
Irish, M., Lawlor, B., Coen, R. and O’Mara, S. (2011a). Everyday episodic memory in amnestic mild cognitive impairment: a preliminary investigation. BMC Neuroscience, 12, 80. doi:10.1186/1471-2202-12-80.CrossRefGoogle ScholarPubMed
Irish, M., Lawlor, B. A., O’Mara, S. M. and Coen, R. F. (2010). Exploring the recollective experience during autobiographical memory retrieval in amnestic mild cognitive impairment. Journal of the International Neuropsychological Society, 16, 546–555. doi:10.1017/S1355617710000172.CrossRefGoogle ScholarPubMed
Irish, M., Lawlor, B. A., O’Mara, S. M. and Coen, R. F. (2011b). Impaired capacity for autonoetic reliving during autobiographical event recall in mild Alzheimer's disease. Cortex, 47, 236–249. doi:10.1016/j.cortex.2010.01.002.CrossRefGoogle ScholarPubMed
Jessen, F. et al. (2014). AD dementia risk in late MCI, in early MCI, and in subjective memory impairment. Alzheimer's & Dementia, 10, 76–83. doi:10.1016/j.jalz.2012.09.017.CrossRefGoogle ScholarPubMed
Kantarci, K. et al. (2012). APOE modifies the association between Aβ load and cognition in cognitively normal older adults. Neurology, 78, 232–240. doi: 10.1212/WNL.0b013e31824365ab.Google ScholarPubMed
Leyhe, T., Müller, S., Milian, M., Eschweiler, G. W. and Saur, R. (2009). Impairment of episodic and semantic autobiographical memory in patients with mild cognitive impairment and early Alzheimer's disease. Neuropsychologia, 47, 2464–2469. doi:10.1016/j.neuropsychologia.2009.04.018.CrossRefGoogle ScholarPubMed
Lim, Y. Y. et al. (2013). Aβ amyloid, cognition, and APOE genotype in healthy older adults. Alzheimer's & Dementia, 9, 538–545. doi:10.1016/j.jalz.2012.07.004.CrossRefGoogle ScholarPubMed
Lim, Y. Y. et al. (2014). Effect of amyloid on memory and non-memory decline from preclinical to clinical Alzheimer's disease. Brain, 137, 221–231. doi:10.1093/brain/awt286.CrossRefGoogle ScholarPubMed
Maguire, E. A. (2001). Neuroimaging studies of autobiographical event memory. Philosophical Transactions of the Royal Society of London. Series B: Biological Sciences, 356, 1441–1451. doi:10.1098/rstb.2001.0944.Google ScholarPubMed
Mormino, E. C. et al. (2009). Episodic memory loss is related to hippocampal-mediated β-amyloid deposition in elderly subjects. Brain, 132, 1310–1323. doi: 10.1093/brain/awn320.Google ScholarPubMed
Moscovitch, M., Yaschyshyn, T., Ziegler, M., Nadel, L. and Tulving, E. (eds.). (2000). Remote episodic memory and retrograde amnesia: was Endel Tulving right all along? In Memory, Consciousness, and the Brain: The Tallinn Conference (pp. 331–345). New York: Psychology Press.Google Scholar
Petersen, R. C., Smith, G. E., Waring, S. C., Ivnik, R. J., Tangalos, E. G. and Kokmen, E. (1999). Mild cognitive impairment: clinical characterization and outcome. Archives of Neurology, 56, 303–308. doi:10.1001/archneur.56.3.303.CrossRefGoogle ScholarPubMed
Pike, K. E. et al. (2011). Cognition and beta-amyloid in preclinical Alzheimer's disease: data from the AIBL study. Neuropsychologia, 49, 2384–2390. doi:10.1016/j.neuropsychologia.2011.04.012.Google ScholarPubMed
Pike, K. E. et al. (2007). Beta-amyloid imaging and memory in non-demented individuals: evidence for preclinical Alzheimer's disease. Brain, 130, 2837–2844. doi:10.1093/brain/awm238.CrossRefGoogle ScholarPubMed
Rentz, D. M. et al. (2011). Face-name associative memory performance is related to amyloid burden in normal elderly. Neuropsychologia, 49, 2776–2783. doi:10.1016/j.neuropsychologia.2011.06.006.Google ScholarPubMed
Robinson, J. A. and Swanson, K. L. (1990). Autobiographical memory: the next phase. Applied Cognitive Psychology, 4, 321–335. doi:10.1002/acp.2350040407.Google Scholar
Rowe, C. C. et al. (2010). Amyloid imaging results from the Australian Imaging, Biomarkers and Lifestyle (AIBL) study of aging. Neurobiology of Aging, 31, 1275–1283. doi:10.1016/j.neurobiolaging.2010.04.007.Google ScholarPubMed
Sperling, R. A. et al. (2010). Criteria for Preclinical Alzheimer's Disease. Available at: http://www.alz.org/research/diagnostic_criteria/preclinical_recommendations.pdf.Google Scholar
Svoboda, E., McKinnon, M. C. and Levine, B. (2006). The functional neuroanatomy of autobiographical memory: a meta-analysis. Neuropsychologia, 44, 2189–2208. doi:10.1016/j.neuropsychologia.2006.05.023.CrossRefGoogle ScholarPubMed
Villemagne, V. L. et al. (2013). Amyloid β deposition, neurodegeneration, and cognitive decline in sporadic Alzheimer's disease: a prospective cohort study. The Lancet Neurology, 12, 357–367. doi:10.1016/S1474-4422(13)70044-9.CrossRefGoogle ScholarPubMed
Wheeler, M. A., Stuss, D. T. and Tulving, E. (1997). Toward a theory of episodic memory: the frontal lobes and autonoetic consciousness. Psychological Bulletin, 121, 331–354. doi:10.1037//0033-2909.121.3.331.Google Scholar
Winblad, B. et al. (2004). Mild cognitive impairment – beyond controversies, towards a consensus: report of the International Working Group on mild cognitive impairment. Journal of Internal Medicine, 256, 240–246. doi:10.1111/j.1365-2796.2004.01380.x.CrossRefGoogle Scholar