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Validation of the Rowland Universal Dementia Assessment Scale (RUDAS) in a multicultural sample across five Western European countries: diagnostic accuracy and normative data

Published online by Cambridge University Press:  18 July 2018

T. Rune Nielsen*
Affiliation:
Danish Dementia Research Centre, University of Copenhagen, Copenhagen, Denmark
Kurt Segers
Affiliation:
Department of Neurology, Brugmann University Hospital, Brussels, Belgium
Valérie Vanderaspoilden
Affiliation:
Department of Neurology, Brugmann University Hospital, Brussels, Belgium
Peter Bekkhus-Wetterberg
Affiliation:
Memory Clinic, Oslo University Hospital Ullevål and Norwegian Center for Minority Health Research, Oslo University Hospital, Oslo, Norway
Guro Hanevold Bjørkløf
Affiliation:
Norwegian National Advisory Unit on Ageing and Health, Vestfold Hospital Trust, Tønsberg, Norway
Ulrike Beinhoff
Affiliation:
Ambulantes Gesundheitszentrum der Charité GmbH, Berlin, Germany
Lennart Minthon
Affiliation:
Clinical Memory Research Unit, Lund University, Malmö, Sweden
Anna Pissiota
Affiliation:
Clinical Memory Research Unit, Lund University, Malmö, Sweden
Magda Tsolaki
Affiliation:
1st Department of Neurology, Aristotle University of Thessaloniki, Thessaloniki, Greece
Mara Gkioka
Affiliation:
1st Department of Neurology, Aristotle University of Thessaloniki, Thessaloniki, Greece
Gunhild Waldemar
Affiliation:
Danish Dementia Research Centre, University of Copenhagen, Copenhagen, Denmark
*
Correspondence should be addressed to: T. Rune Nielsen, Danish Dementia Research Center, Department of Neurology, The Neuroscience Center, University of Copenhagen, Rigshospitalet, section 6922, Blegdamsvej 9, DK-2100 Copenhagen Ø, Denmark. Phone: +45 35 45 71 18. Email: rune.nielsen@regionh.dk.

Abstract

Background:

With increasing cultural diversity and growing elderly immigrant populations in Western European countries, the availability of brief cognitive screening instruments adequate for assessment of dementia in people from diverse backgrounds becomes increasingly important. The aim of the present study was to investigate diagnostic accuracy of the Rowland Universal Dementia Assessment Scale (RUDAS) in a multicultural sample and to calculate normative data as a basis for demographic adjustment of RUDAS scores.

Methods:

The study was a prospective international cross-sectional multi-center study. Receiver operating characteristic curve analysis was used to examine diagnostic accuracy. Regression analysis was used to assess the impact of demographic variables.

Results:

Data was collected from 341 cognitively intact participants and 80 people with dementia with a wide age- and educational range. Of the 421 included participants, 239 (57%) had immigrant background. The RUDAS had high diagnostic accuracy with an area under the curve (AUC) of 0.93. The optimal cut-off score was <25 (sensitivity 0.80, specificity 0.90). Regression analysis revealed that RUDAS scores were mainly affected by education and were unrelated to data collection site and immigrant status. Education-adjusted normative data was calculated as a basis for education adjustment of RUDAS scores. Applying education-adjusted RUDAS scores slightly but significantly improved diagnostic accuracy with an AUC of 0.95.

Conclusion:

We found the RUDAS to have excellent diagnostic properties in our multicultural sample. However, we suggest that RUDAS scores should be adjusted for education to increase diagnostic accuracy and that the choice of cut-off score should be considered based on the clinical context and expected base rate of dementia.

Type
Original Research Article
Copyright
Copyright © International Psychogeriatric Association 2018 

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