Skip to main content Accessibility help
×
Home
Hostname: page-component-5cfd469876-fsxpr Total loading time: 0.224 Render date: 2021-06-23T11:01:45.166Z Has data issue: false Feature Flags: { "shouldUseShareProductTool": true, "shouldUseHypothesis": true, "isUnsiloEnabled": true, "metricsAbstractViews": false, "figures": true, "newCiteModal": false, "newCitedByModal": true, "newEcommerce": true }

Sleep/Wake Cycle Disturbance in Alzheimer's Disease: How Much Is Due to an Inherent Trait?

Published online by Cambridge University Press:  10 January 2005

Jerome A. Yesavage
Affiliation:
Department of Veterans Affairs Health Care System Palo Alto, California, US Department of Psychiatry and Behavioral Sciences, Stanford University School of Medicine, Stanford, California, US
Joy L. Taylor
Affiliation:
Department of Veterans Affairs Health Care System Palo Alto, California, US Department of Psychiatry and Behavioral Sciences, Stanford University School of Medicine, Stanford, California, US
Helena Kraemer
Affiliation:
Department of Psychiatry and Behavioral Sciences, Stanford University School of Medicine, Stanford, California, US
Art Noda
Affiliation:
Department of Psychiatry and Behavioral Sciences, Stanford University School of Medicine, Stanford, California, US
Leah Friedman
Affiliation:
Department of Psychiatry and Behavioral Sciences, Stanford University School of Medicine, Stanford, California, US
Jared R. Tinklenberg
Affiliation:
Department of Veterans Affairs Health Care System Palo Alto, California, US Department of Psychiatry and Behavioral Sciences, Stanford University School of Medicine, Stanford, California, US

Abstract

Major advances in understanding the physiology and genetics of circadian rhythm in the past decade challenge the researcher of sleep/wake disorders in Alzheimer's disease (AD) to distinguish patient characteristics stable across the course of illness (“traits”) from characteristics that vary with stage of illness (“states”). A components-of-variance approach with a repeated measures model was used to examine the between-subjects variance over time (“trait”) vs. within-subjects (“state”) variance in 42 patients with probable AD followed, on average, over 2 years on actigraphic sleep/wake measures. Mental status scores indexed stage of illness. Actigraphic measures of sleep efficiency and circadian rhythmicity appeared predominantly “trait,” with between-individual differences accounting for over 55% of variance compared to the less than 5% of variance related to stage of cognitive impairment. We discuss how “state-trait” analyses can be helpful in identifying areas of assessment most likely to be fruitful objectives of physiologic and genetic research on sleep/wake disturbance in AD.

Type
Articles
Copyright
© 2002 International Psychogeriatric Association

Access options

Get access to the full version of this content by using one of the access options below.
13
Cited by

Send article to Kindle

To send this article to your Kindle, first ensure no-reply@cambridge.org is added to your Approved Personal Document E-mail List under your Personal Document Settings on the Manage Your Content and Devices page of your Amazon account. Then enter the ‘name’ part of your Kindle email address below. Find out more about sending to your Kindle. Find out more about sending to your Kindle.

Note you can select to send to either the @free.kindle.com or @kindle.com variations. ‘@free.kindle.com’ emails are free but can only be sent to your device when it is connected to wi-fi. ‘@kindle.com’ emails can be delivered even when you are not connected to wi-fi, but note that service fees apply.

Find out more about the Kindle Personal Document Service.

Sleep/Wake Cycle Disturbance in Alzheimer's Disease: How Much Is Due to an Inherent Trait?
Available formats
×

Send article to Dropbox

To send this article to your Dropbox account, please select one or more formats and confirm that you agree to abide by our usage policies. If this is the first time you use this feature, you will be asked to authorise Cambridge Core to connect with your <service> account. Find out more about sending content to Dropbox.

Sleep/Wake Cycle Disturbance in Alzheimer's Disease: How Much Is Due to an Inherent Trait?
Available formats
×

Send article to Google Drive

To send this article to your Google Drive account, please select one or more formats and confirm that you agree to abide by our usage policies. If this is the first time you use this feature, you will be asked to authorise Cambridge Core to connect with your <service> account. Find out more about sending content to Google Drive.

Sleep/Wake Cycle Disturbance in Alzheimer's Disease: How Much Is Due to an Inherent Trait?
Available formats
×
×

Reply to: Submit a response

Please enter your response.

Your details

Please enter a valid email address.

Conflicting interests

Do you have any conflicting interests? *