Changes and differences in radial velocities between neutral and ionized metals have been found for three F5-type supergiants: HD 231195, HD 10494, and HD 17971. Fifteen high dispersion coudé spectrograms (6 Å/mm) were used and 33 to 165 lines were measured on each. Semi-regular time variations up to about 8 km s-1 in radial velocity have been found. In addition, Hα line profiles for 8 high luminosity F-K stars have been analyzed. All of the stars show Ha emissions, variable in time, which is probably a common phenomenon in very luminous stars. Metallic emission lines with low excitation potentials, in particular the Ca I 6572.8 and the Fe I 6574.2 lines, are present in 5 of these stars.