When I went to medical school, I was taught that asepsis had its beginnings with Oliver Wendell Holmes, Lord Joseph Lister, and Ignaz Semmelweis. Holmes introduced the concept that puerperal sepsis was spread from patient to patient by physicians. Lister developed the concept that surgical infection was of bacterial origin. Semmelweis proved that childbed fever was transmitted on the contaminated hands of the attendant. In 1846 he effectively used a chloride as an antiseptic for the first time.

Moreover, Semmelweis, on hearing of the death of Professor Kolletschka following a finger pinprick by a scalpel that had been used in an autopsy, noted that the symptoms and outcome were identical to puerperal sepsis. Thus, he established that “cadaverous particles” had lethal potential.

The genus Bacillus is a diverse group of gram-positive, spore-forming aerobic bacilli. B anthracis, the agent of anthrax, is primarily an animal pathogen but is capable of causing human infection, most commonly of the skin or lungs. B cereus, a well-recognized cause of gastroenteritis, may occasionally cause epidemics in health institutions. Both B cereus and other Bacillusspecies are increasingly recognized as opportunistic pathogens in the hospitalized patient. This report is intended as a comprehensive review of the bacteriology, clinical features, and therapy of Bacillus spp infections. Nosocomial epidemics and transmission will be highlighted.

The goal of diagnostic testing is to identify patients with a particular disease. Often, it is just as important that the test not mistakenly identify healthy persons as having disease. For example, a new test for the acquired immunodeficiency syndrome (AIDS) might identify 99.99% of all patients infected with the human immunodeficiency virus (HIV). However, if the test is positive in large numbers of persons who are not infected, its usefulness may be overshadowed by the harm caused by false positive results.