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Risk Factors for and Outcomes of Healthcare-Associated Infection Due to Extended-Spectrum β-Lactamase-Producing Escherichia coli or Klebsiella pneumoniae in Thailand

Published online by Cambridge University Press:  02 January 2015

Anucha Apisarnthanarak ,
Pattarachai Kiratisin ,
Payawan Saifon ,
Rungrueng Kitphati ,
Surang Dejsirilert  and
Linda M. Mundy
Anucha Apisarnthanarak*
Affiliation:
Division of Infectious Diseases, Faculty of Medicine, Thammasart University Hospital, Pratumthani, Thailand
Pattarachai Kiratisin
Affiliation:
Division of Microbiology, Faculty of Medicine, Siriraj Hospital, Bangkok, Thailand
Payawan Saifon
Affiliation:
Division of Microbiology, Faculty of Medicine, Siriraj Hospital, Bangkok, Thailand
Rungrueng Kitphati
Affiliation:
Department of Science, Thai National Institute of Health, Nonthaburi, Thailand
Surang Dejsirilert
Affiliation:
Department of Science, Thai National Institute of Health, Nonthaburi, Thailand
Linda M. Mundy
Affiliation:
Saint Louis University School of Public Health, Saint Louis, Missouri
*
Division of Infectious Diseases, Faculty of Medicine, Thammasart University Hospital, Pratumthani, Thailand12121 (anapisarn@yahoo.com)
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Abstract

A matched case-control study was performed to evaluate the risk factors for and outcomes of healthcare-associated infection due to extended-spectrum β-lactamase-producing Escherichia coli or extended-spectrum β-lactamase-producing Klebsiella pneumoniae in Thailand. By multivariable analysis, prior exposure to third-generation cephalosporins and transfer from another hospital were risk factors associated with infection. Receipt of inadequate antimicrobial therapy was a predictor of mortality.

Type
Concise Communications
Information
Infection Control & Hospital Epidemiology , Volume 28 , Issue 7 , July 2007 , pp. 873 - 876
Copyright
Copyright © The Society for Healthcare Epidemiology of America 2007

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References

1.Meyer, KS, Urban, C, Eagen, JA, Berger, BJ, Rahal, JJ. Nosocomial outbreak of Klebsiella infection resistant to late-generation cephalosporins. Ann Intern Med 1993;119:353–358.Google Scholar
2.Lautenbach, E, Patel, JB, Bilker, WB, Edelstein, PH, Fishman, NO. Extended-spectrum β-lactamase-producing Escherichia colt and Klebsiella pneumoniae: risk factors for infection and impact of resistance on outcomes. Clin Infect Dis 2001;32:1162–1171.Google Scholar
3.Paterson, DL, Ko, WC, Von Gottberg, A, et al.International prospective study of Klebsiella pneumoniae bacteremia: implications of extended-spectrum beta-lactamase production in nosocomial infections. Ann Intern Med 2004;140:26–32.Google Scholar
4.Hyle, EP, Lipworth, AD, Zaoutis, TE, et al.Risk factors for increasing multidrug resistance among extended-spectrum β-lactamase-producing Escherichia coli and Klebsiella pneumoniae. Clin Infect Dis 2005;40:1317–1324.CrossRefGoogle Scholar
5.Kang, CI, Kim, SH, Kim, DM, et al.Risk factors for and clinical outcomes of bloodstream infections caused by extended-spectrum β-lactamase-producing Klebsiella pneumoniae. Infect Control Hosp Epidemiol 2004;25:860–867.Google Scholar
6.Lin, MF, Huang, ML, Lai, SH. Risk factors in the acquisition of extended-spectrum beta-lactamase Klebsiella pneumoniae: a case-control study in a district teaching hospital in Taiwan. J Hosp Infect 2003;53:39–45.CrossRefGoogle Scholar
7.Garner, JS, Jarvis, WR, Emori, TG, Horan, TC, Hughes, JM. CDC definitions for nosocomial infections, 1988. Am J Infect Control 1988;16:128–140.CrossRefGoogle ScholarPubMed
8.Clinincal and Laboratory Standards Institute (CLSI). Performance Standards for Antimicrobial Susceptibility Testing: 16th Informational Supplement. Wayne, PA: CLSI; 2006:M100–S16.Google Scholar
9.Kollef, MH. Inadequate antimicrobial treatment: an important determinant of outcome for hospitalized Patients. Clin Infect Dis 2000;31(suppl 4):S131–S138.Google Scholar
10.Harris, AD, Karchmer, TB, Carmeli, Y, Samore, MH. Methodological principles of case-control studies that analyzed risk factors for antibiotic resistance: a systematic review. Clin Infect Dis 2001;32:1055–1061.Google Scholar