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Pharmacodynamic Properties of Antibiotics: Application to Drug Monitoring and Dosage Regimen Design

Published online by Cambridge University Press:  21 June 2016

Steven C. Ebert  and
William A. Craig
Steven C. Ebert
Affiliation:
University of Wisconsin, Madison, Wisconsin
William A. Craig*
Affiliation:
Department of Medicine, William S. Middleton Memorial Veterans Hospital, Madison, Wisconsin
*
Associate Chief of Staff for Education, William S. Middleton Memorial Veterans Hospital, 2500 Overlook Terrace, Madison, WI 53705
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Extract

The goal of antimicrobial chemotherapy is to effectively eradicate pathogenic organisms while minimizing the likelihood of drug-related adverse effects. In this era of cost containment, consideration should also be given to performing this task with the smallest total dose of drug and the shortest duration of therapy. Determination of the appropriate dose and dosing interval of an antimicrobial requires knowledge and integration of both its pharmacokinetic and pharmacodynamic properties.

Type
Special Sections
Information
Infection Control & Hospital Epidemiology , Volume 11 , Issue 6 , June 1990 , pp. 319 - 326
Copyright
Copyright © The Society for Healthcare Epidemiology of America 1990

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