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Molecular Heterogeneity of Acinetobacter baumanii Isolates During Seasonal Increase in Prevalence

Published online by Cambridge University Press:  02 January 2015

Celia Christie ,
Dorothy Mazon ,
Walter Hierholzer Jr.  and
Jan Evans Patterson
Celia Christie
Affiliation:
Divisions of Infectious Diseases and, Hospital Epidemiology, New Haven, Connecticut
Dorothy Mazon
Affiliation:
Children's Hospital Medical Center, Cincinnati, Ohio, and the Department of Medicine (Infectious Diseases), New Haven, Connecticut
Walter Hierholzer Jr.
Affiliation:
Children's Hospital Medical Center, Cincinnati, Ohio, and the Department of Medicine (Infectious Diseases), New Haven, Connecticut
Jan Evans Patterson
Affiliation:
Children's Hospital Medical Center, Cincinnati, Ohio, and the Department of Medicine (Infectious Diseases), New Haven, Connecticut
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Abstract

Objective:

To study the epidemiology of Acinetobacter baumanii during a period of increased seasonal prevalence.

Design:

Descriptive molecular and clinical epidemiologic study of A baumanii isolates from 1990 through 1992.

Setting:

A 770-bed urban, acute, tertiary-care university hospital.

Results:

During 1990 through 1992, the rate of A baumanii isolations was 30.4 per 1,000 culture isolations during the summer, compared to 12.6 per 1,000 culture isolations during the fall, winter, and spring (P<.000001). There were 320 isolates identified among 260 patients during this time. Eighty-one patients with isolates available were identified for evaluation; they ranged in age from 2 months to 95 years. Pulsed-field gel electrophoresis (PFGE) typing showed that 59 (83%) of 71 typed isolates had distinct PFGE patterns. There were three small clusters of isolates with the same PFGE patterns, suggesting cross-transmission in those instances.

Conclusions:

A seasonally increased prevalence of A baumanii largely associated with device-related nosocomial infections in severely ill patients was noted over a 3-year period. Although there were isolated instances of cross-transmission, most isolates had distinct PFGE patterns. Clonal dissemination of a single strain was not responsible for the seasonal increased prevalence of A baumanii. PFGE typing was useful in directing control efforts.

Type
Original Articles
Information
Infection Control & Hospital Epidemiology , Volume 16 , Issue 10 , October 1995 , pp. 590 - 594
Copyright
Copyright © The Society for Healthcare Epidemiology of America 1995

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