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Infection Control Measures for Human Parvovirus Bl9 in the Hospital Setting

Published online by Cambridge University Press:  21 June 2016

Stanley J. Naides
Stanley J. Naides*
Affiliation:
Department of Internal Medicine, The University of Iowa College of Medicine, and The Veterans Administration Medical Center, Iowa City, Iowa
*
Division of Rheumatology, GH E400, Department of Internal Medicine, University of Iowa College of Medicine, Iowa City, IA 52242
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Extract

A human parvovirus was first discovered serendipitously in blood from asymptomatic donors in 1975' and designated B19 because of the location of the original positive serum in a test panel. Subsequently, the newly discovered virus was determined to be the etiologic agent of most cases of transient aplastic crisis in the setting of chronic hemolytic anemia and of the childhood exanthem erythema infectiosum, or fifth disease. While erythema infectiosum with its classic “slapped-cheek” rash is a childhood illness, “fifth disease” in the adult should not be overlooked. At least 40% of adults lack serological evidence of past human parvovirus B19 infection and are at risk. Adults tend to have a more subtle rash, often lacking the “slapped cheeks,” and tend to have a more severe constitutional, flu-like illness with prominent joint symptoms. While the arthralgia and arthritis of adult “fifth disease” are often self-limiting, they may become chronic and lead to an arthropathy that meets American College of Kheumatology criteria for a diagnosis of rheumatoid arthritis. The arthropathy has been reported to persist up to five years, the longest follow-up now available (A. Wolf; MD, personal communication, August 27, 1987).

Type
Special Sections
Information
Infection Control & Hospital Epidemiology , Volume 10 , Issue 7 , July 1989 , pp. 326 - 329
Copyright
Copyright © The Society for Healthcare Epidemiology of America 1989

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