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Gentamicin and Tobramycin Resistant Gram-Negative Bacilli in a Community Hospital

Published online by Cambridge University Press:  02 January 2015

C. Richard Magnussen  and
Maria Sammartino
C. Richard Magnussen*
Affiliation:
Department of Medicine, University of Rochester School of Medicine and Dentistry, St. Mary's Hospital, Rochester, New York
Maria Sammartino
Affiliation:
Department of Medicine, University of Rochester School of Medicine and Dentistry, St. Mary's Hospital, Rochester, New York
*
Department of Medicine, St. Mary's Hospital, 89 Genesee Street, Rochester, NY 14611
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Abstract

The incidence and spectrum of resistance to gentamicin and tobramycin among gram-negative bacilli (GNB) isolated in a community hospital over a one-year period were studied. The overall incidence of resistance was 3.7%. Pseudomonads constituted almost half of the resistant organisms. The majority of resistant GNB was isolated from the respiratory and urinary tracts. Acquisition of resistance was correlated with both the total use of gentamicin in the hospital and recent treatment of individual patients with gentamicin plus tobramycin. The overall incidence of resistant isolates (3.7%) and the incidence of resistance for the enterobacteriaceae (1.9%) were lower than rates reported by comparable studies at several university or municipal hospitals.

Type
Research Article
Information
Infection Control & Hospital Epidemiology , Volume 1 , Issue 4 , August 1980 , pp. 249 - 252
Copyright
Copyright © The Society for Healthcare Epidemiology of America 1980

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References

1.Gaman, W, Cates, C, Snelling, CFTet al. Emergence of gentamicin and carbenicillin-resistant Pseudomonas aeruginosa in a hospital environment. Antimicrob Aeents Chemother 1976;9:474-80.CrossRefGoogle Scholar
2.Moellering, RC Jr. Wennersten, C.Kunz, LJet al. Resistance to gentamicin, tobramycin and amikacin among clinical isolates of bacteria. Am J Med 1977;62:873-81.CrossRefGoogle ScholarPubMed
3.Siebert, WT, Moreland, XJ, Williams, TW. Resistance to gentamicin: A growing concern. South Med J 1977:70:289-92.CrossRefGoogle ScholarPubMed
4.Jauregui, L. Cushing, RD, Lerner, AM. Gentamicin amikacin resistant gram-negative bacilli at Detroit General Hospital. 1975-1976. Am J Med 1977:62:882-88.CrossRefGoogle ScholarPubMed
5.Rennie, RP, Duncan, IBR. Emergence of gentamicin-resistant Klebsiella in a general hospital. Antimicrob Agents Chemother 1977;11:179-84.CrossRefGoogle ScholarPubMed
6.Kauffman, CA, Ramundo, NC, Williams, SG. et al. Surveillance of gentamicin-resistant gram-negative bacilli in a general hospital. Antimicrob Agents Chemother 1978;13:918-23.CrossRefGoogle ScholarPubMed
7.Roberts, XJ, Douglas, RG Jr. Gentamicin use and Pseudomonas and Serratia resistance: Effect of a surgical prophylaxis regimen. Antimicrob Agents Chemother 1978;13:214-20.CrossRefGoogle ScholarPubMed
8.Ruben, FL, Norden, CW, Hruska, E. Factors associated with acquisition of Pseudomonas aeruginosa resistant to gentamicin. Am J Med Sci 1978;275:173-79.CrossRefGoogle ScholarPubMed
9.Yu, VL, Oakes, CA, Axnick, KJet al. Patient factors contributing to the emergence of gentamicin-resistant Serratia marcescens. Am J Med 1979;66:468-72.CrossRefGoogle Scholar
10.Moellering, RC, Wennersten, C, Kunz, LJ. Emergence of gentamicin-resistant organisms. J Infect Dis 1976:134(supplement):S40–S49.CrossRefGoogle ScholarPubMed
11.Keys, TF, Washington, JA. Gentamicin-resistant Pseudomonas aeruginosa Mayo Clinic experience, 1970-1976. Mayo Clin Proc 1977;52:797–801.Google Scholar
12.Gerding, DN, Buxton, AE, Hughes, RAet al. Nosocomial multiply resistant Klebsiella pneumoniae: Epidemiology of an outbreak of apparent index case origin. Antimicrob Agents Chemother 1979;15:608-15.CrossRefGoogle ScholarPubMed
13.Meyer, RD, Lewis, RP, Halter, Jet al. Gentamicin-resistant Pseudomonas aeruginosa and Serratia marcescens in a general hospital. Lancet 1976;1:580-83.CrossRefGoogle ScholarPubMed
14. Hospital Statistics 1977. American Hospital Association. Chicago, 1978.Google Scholar
15.McCabe, WR, Jackson, GG. Gram-negative bacteremia I. Etiology and ecology. Arch Intern Med 1962;110:847-55.CrossRefGoogle Scholar
16.Bauer, DW, Kirby, WMM, Sherris, JCet al. Antibioticsusceptibility testing by a standard single disc method. Am J Clin Pathol 1966;45:493-96.CrossRefGoogle Scholar
17. Approved Standard: ASM-2. Performance standards for antimicrobial disc susceptibility tests. National Committee for Clinical Laboratory Standards, Villanova, Pa. 1979.Google Scholar
18.Relier, LB, Schoenknecht, FD, Kenny, MAet al. Antibiotic susceptibility testing of Pseudomonas aeruginosa: Selection of a control strain and criteria for magnesium and calcium content in the media. J Infect Dis 1974;130:454-63.CrossRefGoogle Scholar
19.Minshew, BH, Pollock, HM, Schoenknecht, FDet al. Emergence in a burn center of populations of bacteria resistant to gentamicin, tobramycin and amikacin: Evidence for the need for changes in zone diameter interpretative standards. Antimicrob Agents Chemother 1977;12:688-96.CrossRefGoogle Scholar