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Enterobacter sakazakii Infections in Neonates Associated with Intrinsic Contamination of a Powdered Infant Formula

Published online by Cambridge University Press:  21 June 2016

Bryan P. Simmons ,
Michael S. Gelfand ,
Michael Haas ,
Linda Metts  and
John Ferguson
Bryan P. Simmons*
Affiliation:
Methodist Central Hospital, Memphis, Tennessee
Michael S. Gelfand
Affiliation:
Methodist Central Hospital, Memphis, Tennessee
Michael Haas
Affiliation:
Methodist Central Hospital, Memphis, Tennessee
Linda Metts
Affiliation:
Methodist Central Hospital, Memphis, Tennessee
John Ferguson
Affiliation:
Methodist Central Hospital, Memphis, Tennessee
*
188 S. Bellevue, Suite 420, Memphis, TN 38104
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Abstract

We report an outbreak of Enterobacter sakazakii infection and colonization in neonates related to an infant formula contaminated during the manufacturing process. The outbreak occurred in a 2O-bed neonatal intensive care unit during a six-week period in 1988, and involved a total of four infants. Three infants had sepsis and three had bloody diarrhea; all patients responded to intravenous antibiotics and recovered without complications. The E sakazakii isolated from the formula had the same plasmid and multilocus enzyme profile as those isolated from patients. This outbreak demonstrates the significance of commercially contaminated formulas and emphasizes the need to limit contamination and multiplication of bacteria in enteral formulas.

Type
Original Articles
Information
Infection Control & Hospital Epidemiology , Volume 10 , Issue 9 , September 1989 , pp. 398 - 401
Copyright
Copyright © The Society for Healthcare Epidemiology of America 1989

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References

1. US Food and Drug Administration: Bacterial contamination of enteral formula products. EDA Drug Bulletin, November 1988.Google Scholar
2. Muytjens, HL, Koelofs-Willemse, H, Jaspar, GHJ: Quality of powdered substitutes for breast milk with regard to members of the family Entero-bacteriaceae . J Clin Microbiol 1988: 26:743–746.CrossRefGoogle Scholar
3. Anderson, KR, Norris, DJ, Gadfrey, LB, et al: Bacterial contamination of tube-feeding formulas. JPEN J Parenter Enteral Nutr 1984; 8:673–678.CrossRefGoogle ScholarPubMed
4. Gill, KJ. Gill, P: Contaminated enteral feeds. Br Med J 1981; 282:1971.CrossRefGoogle ScholarPubMed
5. Fagerman, KE: Pharmacy admixture of enteral nutrient products. Am J Hasp Pharm 1986; 43:884.Google Scholar
6. Casewell, EW: Enteral feeds contaminated with Enterobacter cloacae as a cause of septicemia, Br Med J 1981: 282:973.CrossRefGoogle Scholar
7. Baldwin, BA. Zagoren, AJ, Rose, X: Bacterial contamination of continuously infused enteral alimentation with needle catheter jejunostomy–Clinical implications. JPEN J Patenter Enteral Nutr 1983; 8:30–33.CrossRefGoogle Scholar
8. Schroeder, P. Fisher, D, Yolz., M. et al: Microbial contamination of enteral feeding solutions in a community hospital. JPEN J Parenter Enteral Nutr 1983; 7:364–368.CrossRefGoogle Scholar
9. Ristuccia, PA. Cunah, BA: Enterobacter. Infect Control 1985; 6:124–128.CrossRefGoogle Scholar
10. Arseni, A. Malamau-Landas, E, Koutsia, C, et al: Outbreak of colonization of neonates with Enterobacter sakazakii . J Hosp Infect 1987; 9:143–150.CrossRefGoogle ScholarPubMed
11. Muytjens, HL. Zanen, HC, Sonderkamp, HJ, et al: Analysis of eight cases of neonatal meningitis and sepsis due to Enterobacter sakazakii . J Clin Microbiol 1983; 18:115–120.10.1128/jcm.18.1.115-120.1983CrossRefGoogle ScholarPubMed
12. Clark, NC, Hill, BC, O'Hara, CM, et al: Use of electrophoretic analyses to identify dried infinit formula as the source of Enterobacter sakazakii neonatal infections. Abstract Lit), page 482. Abstracts of the 89th Annual Meeting of the American Society for Microbiology, 1989.Google Scholar
13. Cransden, WR, Webster, M, French, GL. et al: An outbreak of Serratia marcescens transmitted by contaminated breast pumps in a special care baby unit. J Hosp Infect 1986; 7:149–154.CrossRefGoogle Scholar
14. Hostetler, C. Lipman, TO, Geraghty, M, et al: Bacterial safety and reconstituted continuous drip tube feeding. JPEN J Parenter Enteral Nutr 1982; 6:232–235.CrossRefGoogle ScholarPubMed
15. McWey, RE, Curry, NS, Schabel, SI. et al: Complications of nasoenteric feeding tubes. Am J Surg 1988; 155:253–257.CrossRefGoogle ScholarPubMed