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Duration of Virus Shedding After Trivalent Intranasal Live Attenuated Influenza Vaccination in Adults

Published online by Cambridge University Press:  21 June 2016

Thomas R. Talbot ,
Deidre D. Crocker ,
Jody Peters ,
Jennifer K. Doersam ,
Mine R. Ikizler ,
Edith Sannella ,
Peter F. Wright  and
Kathryn M. Edwards
Thomas R. Talbot*
Affiliation:
Division of Infectious Diseases, Departments of Medicine and Preventive Medicine, Vanderbilt University School of Medicine, Nashville, Tennessee
Deidre D. Crocker
Affiliation:
Division of Infectious Diseases, Department of Pediatrics, Vanderbilt University School of Medicine, Nashville, Tennessee
Jody Peters
Affiliation:
Division of Infectious Diseases, Department of Pediatrics, Vanderbilt University School of Medicine, Nashville, Tennessee
Jennifer K. Doersam
Affiliation:
Division of Infectious Diseases, Department of Pediatrics, Vanderbilt University School of Medicine, Nashville, Tennessee
Mine R. Ikizler
Affiliation:
Division of Infectious Diseases, Department of Pediatrics, Vanderbilt University School of Medicine, Nashville, Tennessee
Edith Sannella
Affiliation:
Division of Infectious Diseases, Department of Pediatrics, Vanderbilt University School of Medicine, Nashville, Tennessee
Peter F. Wright
Affiliation:
Division of Infectious Diseases, Department of Pediatrics, Vanderbilt University School of Medicine, Nashville, Tennessee
Kathryn M. Edwards
Affiliation:
Division of Infectious Diseases, Department of Pediatrics, Vanderbilt University School of Medicine, Nashville, Tennessee Pediatric Clinical Research Office, Vanderbilt University School of Medicine, Nashville, Tennessee
*
A-2200 Medical Center North, 1161 21st Avenue South, Vanderbilt University Medical Center, Nashville, TN37232. tom.talbot@vanderbilt.edu
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Abstract

Objective:

To characterize the probability and duration of viral shedding among adults given trivalent live attenuated influenza vaccine (LATV).

Design:

Prospective surveillance study.

Methods:

Nasal wash samples were collected from adult volunteers at baseline and on days 3, 7, and 10 and between days 17 and 21 following intranasal LAIV vaccination. The presence, titer, and identification of each specific strain of influenza virus shed were determined by standard methodology.

Results:

Twenty subjects received LATV. No samples were positive for influenza virus at baseline. After LAIV vaccination, influenza virus was recovered from 10 of 20 vaccinees on day 3, from 1 of 18 vaccinees on day 7, and from none of the samples on days 10 or 17 through 21. Vaccinees who shed vaccine virus were significantly younger than those who did not (mean age, 26.4 vs 38.6 years; P < .01). Although the presence of specific mucosal immunoglobulin A to influenza B was associated with significantly less shedding of influenza B after vaccination (P = .02), associations of shedding with other measures of immunity were not detected.

Conclusion:

The duration of shedding of vaccine virus after LAIV in adults is limited and may be associated with an individual's prior influenza vaccination history.

Type
Original Articles
Information
Infection Control & Hospital Epidemiology , Volume 26 , Issue 5 , May 2005 , pp. 494 - 500
Copyright
Copyright © The Society for Healthcare Epidemiology of America 2005

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