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Clostridioides difficile infection across the lifespan: Estimation using life tables

Published online by Cambridge University Press:  25 January 2024

Derek S. Brown
Affiliation:
George Warren Brown School of Social Work, Washington University, St. Louis, Missouri
Margaret A. Olsen*
Affiliation:
Department of Medicine, Washington University School of Medicine, St. Louis, Missouri
Matthew R. Keller
Affiliation:
Department of Medicine, Washington University School of Medicine, St. Louis, Missouri
Dustin Stwalley
Affiliation:
Department of Medicine, Washington University School of Medicine, St. Louis, Missouri
Andrew D. Tipping
Affiliation:
Department of Medicine, Washington University School of Medicine, St. Louis, Missouri
Holly Yu
Affiliation:
Pfizer, Inc, Pearl River, New York
Erik R. Dubberke
Affiliation:
Department of Medicine, Washington University School of Medicine, St. Louis, Missouri
*
Corresponding author: Margaret A. Olsen; Email: molsen@wustl.edu

Abstract

Using a life tables approach with 2011–2017 claims data, we calculated lifetime risks of Clostridioides difficile infection (CDI) beginning at age 18 years. The lifetime CDI risk rates were 32% in female patients insured by Medicaid, 10% in commercially insured male patients, and almost 40% in females with end-stage renal disease.

Type
Concise Communication
Copyright
© The Author(s), 2024. Published by Cambridge University Press on behalf of The Society for Healthcare Epidemiology of America

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Footnotes

Present affiliation: Missouri Institute of Mental Health, St. Louis, MO [A.D.T.]

References

Emerging Infections Program, Healthcare-Associated Infections—Community Interface Surveillance Report, Clostridioides difficile Infection. Centers for Disease Control and Prevention website. https://www.cdc.gov/hai/eip/Annual-CDI-Report-2020.html. Published 2020. Accessed February 6, 2023.Google Scholar
Donskey, CJ. Update on Clostridioides difficile infection in older adults. Infect Dis Clin N Am 2023;37:87102.CrossRefGoogle ScholarPubMed
Olsen, MA, Stwalley, D, Tipping, AD, Keller, MR, Yu, H, Dubberke, ER. Trends in the incidence of Clostridioides difficile infection in adults and the elderly insured by Medicaid compared to commercial insurance or Medicare only. Infect Control Hosp Epidemiol 2023;44:10761084.CrossRefGoogle ScholarPubMed
Ramesh, MS, Yee, J. Clostridioides difficile infection in chronic kidney disease/end-stage renal disease. Adv Chronic Kidney Dis 2019;26:3034.CrossRefGoogle ScholarPubMed
Arias, E. United States life tables, 2017. Natl Vital Stat Rep 2019;68:166.Google ScholarPubMed
Carey, IM, Critchley, JA, DeWilde, S, Harris, T, Hosking, FJ, Cook, DG. Risk of infection in type 1 and type 2 diabetes compared with the general population: a matched cohort study. Diab Care 2018;41:513521.10.2337/dc17-2131CrossRefGoogle ScholarPubMed
Kwon, JH, Wi, CI, Seol, HY, et al. Risk, Mechanisms and implications of asthma-associated infectious and inflammatory multimorbidities (AIMs) among individuals with asthma: a systematic review and a case study. Allergy Asthma Immunol Res 2021;13:697718.CrossRefGoogle ScholarPubMed
Ishigami, J, Matsushita, K. Clinical epidemiology of infectious disease among patients with chronic kidney disease. Clin Exp Nephrol 2019;23:437447.CrossRefGoogle ScholarPubMed
Fleming-Dutra, KE, Hersh, AL, Shapiro, DJ, et al. Prevalence of inappropriate antibiotic prescriptions among US ambulatory care visits, 2010–2011. JAMA 2016;315:18641873.CrossRefGoogle ScholarPubMed
Miller, AC, Segre, AM, Pemmaraju, SV, Sewell, DK, Polgreen, PM. Association of household exposure to primary Clostridioides difficile infection with secondary infection in family members. JAMA Netw Open 2020;3:e208925.CrossRefGoogle ScholarPubMed
Olsen, MA, Stwalley, D, Demont, C, Dubberke, ER. Clostridium difficile infection increases acute and chronic morbidity and mortality. Infect Control Hosp Epidemiol 2019;40:6571.CrossRefGoogle ScholarPubMed
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