Hostname: page-component-848d4c4894-2xdlg Total loading time: 0 Render date: 2024-06-21T23:06:25.807Z Has data issue: false hasContentIssue false
  • English
  • Français

Clinical Experience With Minocycline and Rifampin-Impregnated Central Venous Catheters in Bone Marrow Transplantation Recipients: Efficacy and Low Risk of Developing Staphylococcal Resistance

Published online by Cambridge University Press:  02 January 2015

Ioannis Chatzinikolaou ,
Hend Hanna ,
Linda Graviss ,
Gassan Chaiban ,
Cheryl Perego ,
Rebecca Arbuckle ,
Richard Champlin ,
Rabih Darouiche ,
George Samonis  and
Issam Raad
Ioannis Chatzinikolaou
Affiliation:
Division of Internal Medicine, Department of Infectious Diseases, Infection Control and Employee Health, University of Texas, M. D. Anderson Cancer Center, Houston, Texas Division of Internal Medicine, Department of Infectious Diseases, School of Medicine, University of Crete, Greece
Hend Hanna*
Affiliation:
Division of Internal Medicine, Department of Infectious Diseases, Infection Control and Employee Health, University of Texas, M. D. Anderson Cancer Center, Houston, Texas
Linda Graviss
Affiliation:
Division of Internal Medicine, Department of Infectious Diseases, Infection Control and Employee Health, University of Texas, M. D. Anderson Cancer Center, Houston, Texas
Gassan Chaiban
Affiliation:
Division of Internal Medicine, Department of Infectious Diseases, Infection Control and Employee Health, University of Texas, M. D. Anderson Cancer Center, Houston, Texas
Cheryl Perego
Affiliation:
Division of Internal Medicine, Department of Infectious Diseases, Infection Control and Employee Health, University of Texas, M. D. Anderson Cancer Center, Houston, Texas
Rebecca Arbuckle
Affiliation:
Division of Pharmacy, University of Texas, M. D. Anderson Cancer Center, Houston, Texas
Richard Champlin
Affiliation:
Department of Bone Marrow Transplantation, University of Texas, M. D. Anderson Cancer Center, Houston, Texas
Rabih Darouiche
Affiliation:
Section of Infectious Diseases, VA Medical Center and Baylor College of Medicine, Houston, Texas
George Samonis
Affiliation:
Division of Internal Medicine, Department of Infectious Diseases, School of Medicine, University of Crete, Greece
Issam Raad
Affiliation:
Division of Internal Medicine, Department of Infectious Diseases, Infection Control and Employee Health, University of Texas, M. D. Anderson Cancer Center, Houston, Texas
*
Department of Infectious Diseases, Infection Control and Employee Health, The University of Texas, M. D. Anderson Cancer Center, 1515 Holcombe Boulevard (Unit 402), Houston, TX 77030
Get access Rights & Permissions [Opens in a new window]

Abstract

In this retrospective evaluation of the 4-year clinical use of minocycline and rifampin-impregnated catheters in bone marrow transplantation (BMT) patients, we report low risk of development of staphylococcal resistance to the antibiotics coating the catheters and efficacy in preventing primary staphylococcal bloodstream infections.

Type
Concise Communications
Information
Infection Control & Hospital Epidemiology , Volume 24 , Issue 12 , December 2003 , pp. 961 - 963
Copyright
Copyright © The Society for Healthcare Epidemiology of America 2003 

Access options

Get access to the full version of this content by using one of the access options below. (Log in options will check for institutional or personal access. Content may require purchase if you do not have access.)

References

1. Raad, I, Darouiche, R, Dupuis, J, et al. Central venous catheters coated with minocycline and rifampin for the prevention of catheter-related colonization and bloodstream infections: a randomized, double-blind trial. Ann Intern Med 1997;127:267–274.10.7326/0003-4819-127-4-199708150-00002Google Scholar
2. Darouiche, RO, Raad, II, Heard, SO, et al. A comparison of two antimicrobial-impregnated central venous catheters. N Engl J Med 1999;340:1–8.10.1056/NEJM199901073400101Google Scholar
3. Hanna, H, Benjamin, RS, Chatzinikolaou, I, et al. The role of long-term silicone central venous catheters impregnated with rifampin and minocycline (S-CVC-RM) in preventing catheter-related infections: a prospective randomized study. Presented at the 38th Annual Meeting of the American Society of Clinical Oncology; May 18-21, 2002; Orlando, FL.Google Scholar
4. Tambe, SM, Sampath, L, Modak, SM. In vitro evaluation of the risk of developing bacterial resistance to antiseptics and antibiotics used in medical devices. J Antimicrob Chemother 2001;47:589–598.10.1093/jac/47.5.589Google Scholar
5. Sampath, LA, Tambe, SM, Modak, SM. In vitro and in vivo efficacy of catheters impregnated with antiseptics or antibiotics: evaluation of the risk of bacterial resistance to the antimicrobials in the catheters. Infect Control Hosp Epidemiol 2001;22:640–646.10.1086/501836Google Scholar
6. Benezra, D, Kiehn, TE, Gold, JW, Brown, AE, Turnbull, AD, Armstrong, D. Prospective study of infections in indwelling central venous catheters using quantitative blood cultures. Am J Med 1988;85:495–498.10.1016/S0002-9343(88)80084-6Google Scholar
7. Darouiche, RO, Raad, II, Bodey, GP, Musher, DM. Antibiotic susceptibility of staphylococcal isolates from patients with vascular catheter-related bacteremia: potential role of the combination of minocycline and rifampin. Int J Antimicrob Agents 1995;6:31–36.10.1016/0924-8579(95)00017-3Google Scholar
8. National Committee for Clinical Laboratory Standards. Methods for Dilution Antimicrobial Susceptibility Tests for Bacteria That Grow Aerobically. Wayne, PA: National Committee for Clinical Laboratory Standards; 2000.Google Scholar
9. Herwaldt, LA, Geiss, M, Kao, C, Pfaller, MA. The positive predictive value of isolating coagulase-negative staphylococci from blood cultures. Clin Infect Dis 1996;22:14–20.10.1093/clinids/22.1.14Google Scholar
10. Hanna, HA, Raad, I. Blood products: a significant risk factor for long-term catheter-related bloodstream infections in cancer patients. Infect Control Hosp Epidemiol 2001;22:165–166.10.1086/501885Google Scholar