Hostname: page-component-77c89778f8-fv566 Total loading time: 0 Render date: 2024-07-21T00:43:25.497Z Has data issue: false hasContentIssue false
  • English
  • Français

Pilot Trial of N-acetylcysteine and Tigecycline as a Catheter-Lock Solution for Treatment of Hemodialysis Catheter–Associated Bacteremia

Published online by Cambridge University Press:  02 January 2015

Saima Aslam ,
Barbara W. Trautner ,
Venkat Ramanathan  and
Rabih O. Darouiche
Saima Aslam*
Affiliation:
Sections of Infectious Disease, Houston, Texas Baylor College of Medicine, and the Michael E. DeBakey Veterans Affairs Medical Center, Houston, Texas
Barbara W. Trautner
Affiliation:
Sections of Infectious Disease, Houston, Texas Baylor College of Medicine, and the Michael E. DeBakey Veterans Affairs Medical Center, Houston, Texas
Venkat Ramanathan
Affiliation:
Nephrology, Houston, Texas Baylor College of Medicine, and the Michael E. DeBakey Veterans Affairs Medical Center, Houston, Texas
Rabih O. Darouiche
Affiliation:
Sections of Infectious Disease, Houston, Texas Department of Medicine, and the Center for Prostheses Infection, Houston, Texas Baylor College of Medicine, and the Michael E. DeBakey Veterans Affairs Medical Center, Houston, Texas
*
2002 Holcombe Blvd., Room 4B-370, Section of Infectious Disease, Michael E. DeBakey Veterans Affairs Medical Center, Houston, TX 77030 (saslam@bcm.tmc.edu)
Get access Rights & Permissions [Opens in a new window]

Abstract

We evaluated a catheter-lock solution consisting of N-acetylcysteine, tigecycline, and heparin for catheter salvage in patients with hemodialysis catheter-associated bacteremia. Eighteen case patients received the catheter-lock solution for 14 days plus systemic antibiotic therapy. Treatment was successful for 15 (83%) of the 18 case patients within 90 days of follow-up, with a median catheter retention interval of 64.5 days.

Trial registration. ClinicalTrials.gov identifier: NCT00614679.

Type
Concise Communication
Information
Infection Control & Hospital Epidemiology , Volume 29 , Issue 9 , September 2008 , pp. 894 - 897
Copyright
Copyright © The Society for Healthcare Epidemiology of America 2008

Access options

Get access to the full version of this content by using one of the access options below. (Log in options will check for institutional or personal access. Content may require purchase if you do not have access.)

References

1.Aslam, S, Trautner, BW, Ramanathan, V, Darouiche, RO. Combination of tigecycline and N-acetylcysteine reduces biofilm-embedded bacteria on vascular catheters. Antimicrob Agents Chemother 2007;51:1556–1558.CrossRefGoogle ScholarPubMed
2.Raad, I, Hanna, HA, Alakech, B, Chatzinikolaou, I, Johnson, MM, Tarrand, J. Differential time to positivity: a useful method for diagnosing catheter-related bloodstream infections. Ann Intern Med 2004;140:18–25.CrossRefGoogle ScholarPubMed
3.Maki, DG, Weise, CE, Sarafin, HW. A semiquantitative culture method for identifying intravenous-catheter-related infection. N Engl J Med 1977;296:1305–1309.CrossRefGoogle ScholarPubMed
4.Raad, II, Sabbagh, MF, Rand, KH, Sherertz, RJ. Quantitative tip culture methods and the diagnosis of central venous catheter-related infections. Diagn Microbiol Infect Dis 1992;15:13–20.CrossRefGoogle ScholarPubMed
5.Maya, ID, Carlton, D, Estrada, E, Allon, M. Treatment of dialysis catheter-related Staphylococcus aureus bacteremia with an antibiotic lock: a quality improvement report. Am J Kidney Dis 2007;50:289–295.CrossRefGoogle Scholar
6.Poole, CV, Carlton, D, Bimbo, L, Allon, M. Treatment of catheter-related bacteraemia with an antibiotic lock protocol: effect of bacterial pathogen. Nephrol Dial Transplant 2004;19:1237–1244.CrossRefGoogle ScholarPubMed
7.Krishnasami, Z, Carlton, D, Bimbo, L, et al.Management of hemodialysis catheter-related bacteremia with an adjunctive antibiotic lock solution. Kidney Int 2002;61:1136–1142.CrossRefGoogle ScholarPubMed
8.Vardhan, A, Davies, J, Daryanani, I, Crowe, A, McClelland, P. Treatment of haemodialysis catheter-related infections. Nephrol Dial Transplant 2002;17:1149–1150.CrossRefGoogle ScholarPubMed
9.Marchese, A, Bozzolasco, M, Gualco, L, Debbia, EA, Schito, GC, Schito, AM. Effect of fosfomycin alone and in combination with N-acetylcysteine on E. coli biofilms. Int J Antimicrob Agents 2003;22(Suppl 2):95–100.CrossRefGoogle ScholarPubMed
10.Marr, KA, Sexton, DJ, Conlon, PJ, Corey, GR, Schwab, SJ, Kirkland, KB. Catheter-related bacteremia and outcome of attempted catheter salvage in patients undergoing hemodialysis. Ann Intern Med 1997;127:275–280.CrossRefGoogle ScholarPubMed