Hostname: page-component-76fb5796d-qxdb6 Total loading time: 0 Render date: 2024-04-27T01:51:35.859Z Has data issue: false hasContentIssue false
  • English
  • Français

Nosocomial Infections With Ceftazidime-Resistant Pseudomonas aeruginosa: Risk Factors and Outcome

Published online by Cambridge University Press:  02 January 2015

Sai-Cheong Lee ,
Chang-Phone Fung ,
Peter Yuk-Fong Liu ,
Tzu-Chien Wang ,
Lai-Chu See ,
Ning Lee ,
Shu-Chu Chen  and
Wen-Bin Shieh
Sai-Cheong Lee*
Affiliation:
Division of Infectious Diseases, Chang GungMemorial Hospital, Keelung
Chang-Phone Fung
Affiliation:
Division of Infectious Diseases, Veterans General Hospital, Taipei
Peter Yuk-Fong Liu
Affiliation:
Department of Internal Medicine, Shalu Tung's Memorial Hospital, Chang Gung College of Medicine and Technology, Taiwan, Republic of China
Tzu-Chien Wang
Affiliation:
Department of Molecular and Cellular Biology, Chang Gung College of Medicine and Technology, Taiwan, Republic of China
Lai-Chu See
Affiliation:
Department of Public Health, Chang Gung College of Medicine and Technology, Taiwan, Republic of China
Ning Lee
Affiliation:
Department of Pathology, Chang GungMemorial Hospital, Keelung
Shu-Chu Chen
Affiliation:
Division of Infectious Diseases, Chang GungMemorial Hospital, Keelung
Wen-Bin Shieh
Affiliation:
Division of Infectious Diseases, Chang GungMemorial Hospital, Keelung
*
Division of Infectious Diseases, Chang Gung Memorial Hospital, 222 Mai Chin Rd, Keelung, Taiwan, Republic of China
Get access Rights & Permissions [Opens in a new window]

Abstract

Prospective studies were conducted for nosocomial Pseudomonas aeruginosa infections from February 1, 1994, to October 30,1995. Of 97 P aeruginosa isolates from 97 patients, 35 were resistant to ceftazidime. Logistic regression revealed previous cephalosporin or piperacillin use as independent risk factors for nosocomial ceftazidime-resistant P aeruginosa infection. Pulsed-field gel electrophoresis revealed that four nosocomial ceftazidime-resistant P aeruginosa infections were caused by cross-infection, probably through medical personnel.

Type
Concise Communications
Information
Infection Control & Hospital Epidemiology , Volume 20 , Issue 3 , March 1999 , pp. 205 - 207
Copyright
Copyright © The Society for Healthcare Epidemiology of America 1999

Access options

Get access to the full version of this content by using one of the access options below. (Log in options will check for institutional or personal access. Content may require purchase if you do not have access.)

References

1. Young, LS. The clinical challenge of infections due to P aeruginosa . Rev Infect Dis 1984;6:S603–S607.CrossRefGoogle Scholar
2. Classen, DC, Jacobson, JA, Burke, JP, Jacobson, JT, Evans, RS. Serious Pseudomonas infections associated with endoscopic retrograde cholangiopancreatography. Am J Med 1988;84:590–595.CrossRefGoogle ScholarPubMed
3. Foord, RD. The emergence of resistance of P aeruginosa in patients treated with ceftazidime. Scand J Infect Dis 1987;19:143.CrossRefGoogle ScholarPubMed
4. McCabe, WR, Jackson, GG. Gram negative bacteremia, I: etiology and ecology. Arch Intern Med 1962;110:847–855.CrossRefGoogle Scholar
5. Fagon, JY, Chastre, J, Novara, A, Medioni, P, Gibert, C. Characterization of intensive care unit patients using a model based on the presence or absence of organ dysfunctions and/or infection: the ODIN. Intensive Care Med 1993;19:137–144.CrossRefGoogle ScholarPubMed
6. Gilligan, PH, Woods, GL. Manual of Clinical Microbiology. 6th ed. Washington, DC: American Society of Microbiology; 1995:509-519, 1327–1341.Google Scholar
7. Garner, JS, Jarvis, WR, Emori, TG. CDC definitions for nosocomial infections 1988. Am J Infect Control 1988;16:128–140.CrossRefGoogle ScholarPubMed
8. Tenover, FC, Albeit, RD, Goering, RV, Mickelsen, PA, Murray, BE, Persing, DH, et al. Interpreting chromosomal DNA restriction patterns produced by pulsed-field gel electrophoresis: criteria for bacterial strain typing. J Clin Microbiol 1995;33:2233–2239.CrossRefGoogle ScholarPubMed
9. Dice, LR. Measures of the amount of ecological association between species. Ecology 1945;26:297–302.CrossRefGoogle Scholar
10. Lortholary, O, Fagon, JY, Hoi, AB, Slama, MA, Pierre, J, Girai, P, et al. Nosocomial acquisition of multiresistant Acinetobacter baumannii: risk factors and prognosis. Clin Infect Dis 1995;20:790–796.CrossRefGoogle ScholarPubMed
11. Lucet, IC, Chevret, S, Decre, D, Vanjak, D, Macrez, A, Bedos, JP, et al. Outbreak of multiply resistant Enterobacteriaceae in an intensive care unit: epidemiology and risk factors for acquisition. Clin Infect Dis 1996; 22: 430–436.CrossRefGoogle Scholar
12. Jacobson, KL, Cohen, SH, Inciardi, JF, King, JH, Lippert, WE, Iglesias, T, et al. The relationship between antecedent antibiotic use and resistance to extended-spectrum cephalosporins in group I ß-lactamase producing organisms. Clin Infect Dis 1995;21:1107–1113.CrossRefGoogle Scholar