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Molecular Characteristics of Outbreaks of Nosocomial Infection with Influenza A/H3N2 Virus Variants

Published online by Cambridge University Press:  02 January 2015

Taeko Oguma*
Affiliation:
Division of Public Health, Department of Infectious Disease Control and International Medicine, Graduate School of Medical and Dental Sciences, Niigata University, Niigata, Japan
Reiko Saito
Affiliation:
Division of Public Health, Department of Infectious Disease Control and International Medicine, Graduate School of Medical and Dental Sciences, Niigata University, Niigata, Japan
Hironori Masaki
Affiliation:
Masaki Clinic, Nagasaki, Japan
Kazuhiko Hoshino
Affiliation:
Tagami Hospital, Nagasaki, Japan
Hassan Zaraket
Affiliation:
Division of Public Health, Department of Infectious Disease Control and International Medicine, Graduate School of Medical and Dental Sciences, Niigata University, Niigata, Japan
Yasushi Suzuki
Affiliation:
Division of Public Health, Department of Infectious Disease Control and International Medicine, Graduate School of Medical and Dental Sciences, Niigata University, Niigata, Japan
Isolde Caperig-Dapat
Affiliation:
Division of Public Health, Department of Infectious Disease Control and International Medicine, Graduate School of Medical and Dental Sciences, Niigata University, Niigata, Japan
Clyde Dapat
Affiliation:
Division of Public Health, Department of Infectious Disease Control and International Medicine, Graduate School of Medical and Dental Sciences, Niigata University, Niigata, Japan
Tatiana Baranovich
Affiliation:
Division of Public Health, Department of Infectious Disease Control and International Medicine, Graduate School of Medical and Dental Sciences, Niigata University, Niigata, Japan
Reiki Kuroki
Affiliation:
Tagami Hospital, Nagasaki, Japan
Yasushi Makimoto
Affiliation:
Tagami Hospital, Nagasaki, Japan
Yutaka Shirahige
Affiliation:
Nagasaki Doctors' Network for Home Medical Care, Nagasaki, Japan
Norichika Asoh
Affiliation:
Juzenkai Hopital, Nagasaki, Japan
Satoshi Degawa
Affiliation:
Aino Memorial Hospital, Unzen, Japan
Hidefumi Ishikawa
Affiliation:
Nagasaki Doctors' Network for Home Medical Care, Nagasaki, Japan
Hironobu Kageura
Affiliation:
Kageura Clinic, Nagasaki, Japan
Maki Hosoi
Affiliation:
Division of Public Health, Department of Infectious Disease Control and International Medicine, Graduate School of Medical and Dental Sciences, Niigata University, Niigata, Japan
Hiroshi Suzuki
Affiliation:
Division of Public Health, Department of Infectious Disease Control and International Medicine, Graduate School of Medical and Dental Sciences, Niigata University, Niigata, Japan
*
Division of Public Health, Department of Infectious Disease Control and International Medicine, Graduate School of Medical and Dental Sciences, Niigata University, 1-757, Asahimachi-Dori, Chuoku, Niigata City, Niigata Prefecture 951-8510, Japan (t-oguma@med.niigata-u.ac.jp)

Abstract

Objective.

To describe outbreaks of nosocomial influenza infection with molecular methods and to elucidate the viral linkages among outbreak case patients including both inpatients and healthcare workers (HCWs).

Setting.

A 180-bed acute and long-term care hospital in Japan.

Methods.

Retrospective observational study of nosocomial outbreaks of infection with influenza A/H3N2. Together with information about onset dates and vaccination history, we obtained nasopharyngeal swab samples from individuals with cases of influenza or influenzalike illness (ILI). The hemagglutinin genes of the recovered viruses were sequenced and compared, along with those of community-circulating strains, for similarity by phylogenetic tree analysis.

Results.

The outbreaks occurred from February 26 through April 3, 2007, during the 2006–2007 epidemic season, and they involved 11 patients and 13 HCWs. The 2 outbreaks involved 2 different genotypes of influenza A/H3N2 viruses. These virus variants were closely related to the influenza strains that were circulating in the community during the same epidemic season.

Conclusion.

This study showed the dissemination of highly homologous influenza virus variants among inpatients and HCWs within a short period, as a result of nosocomial transmission. These strains were also similar to influenza strains that were circulating in the community.

Type
Original Article
Copyright
Copyright © The Society for Healthcare Epidemiology of America 2011

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