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Is High Consumption of Antibiotics Associated with Clostridium difficile Polymerase Chain Reaction–Ribotype 027 Infections in France?

Published online by Cambridge University Press:  02 January 2015

Gabriel Birgand
Regional Coordinating Center for Nosocomial Infection Control, Paris, France
Katiuska Miliani
Regional Coordinating Center for Nosocomial Infection Control, Paris, France
Anne Carbonne
Regional Coordinating Center for Nosocomial Infection Control, Paris, France
Pascal Astagneau*
Regional Coordinating Center for Nosocomial Infection Control, Paris, France Department of Epidemiology and Public Health, Pierre et Marie Curie University School of Medicine, Paris, France
C-CLIN Paris Nord, Centre des Cordeliers, Université Pierre et Marie Curie, 15 Rue de l'Ecole de Médecine, 75006 Paris, France (


We compared antibiotic consumption between hospitals affected by a strain of Clostridium difficile designated as polymerase chain reaction–ribotype 027 (CD-027) and those unaffected during an outbreak in northern France. The mean consumption of several β-lactams, amikacin, and fluoroquinolones was high in affected hospitals (P<.05). However, only levofloxacin and imipenem remained associated with emerging CD-027 in the multivariate analysis, suggesting that those antibiotics should be better targeted by prevention campaigns.

Concise Communications
Copyright © The Society for Healthcare Epidemiology of America 2010

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