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Association between chlorhexidine gluconate concentrations and resistant bacterial bioburden on skin

Published online by Cambridge University Press:  11 October 2019

Gita Nadimpalli
Affiliation:
Department of Epidemiology and Public Health, University of Maryland School of Medicine, Baltimore, Maryland
Lyndsay M. O’Hara
Affiliation:
Department of Epidemiology and Public Health, University of Maryland School of Medicine, Baltimore, Maryland
Surbhi Leekha
Affiliation:
Department of Epidemiology and Public Health, University of Maryland School of Medicine, Baltimore, Maryland
David P. Calfee
Affiliation:
Division of Infectious Diseases, Weill Cornell Medicine, New York, New York
Loren G. Miller
Affiliation:
LA Biomedical Research Center at Harbor-UCLA Medical Center, Torrance, California
Lisa Pineles
Affiliation:
Department of Epidemiology and Public Health, University of Maryland School of Medicine, Baltimore, Maryland
Natalia Blanco
Affiliation:
Department of Epidemiology and Public Health, University of Maryland School of Medicine, Baltimore, Maryland
J. Kristie Johnson
Affiliation:
Department of Epidemiology and Public Health, University of Maryland School of Medicine, Baltimore, Maryland Department of Pathology, University of Maryland School of Medicine, Baltimore, Maryland
Anthony D. Harris*
Affiliation:
Department of Epidemiology and Public Health, University of Maryland School of Medicine, Baltimore, Maryland
*
Author for correspondence: Dr Anthony Harris, Email: aharris@epi.umaryland.edu

Abstract

We studied the association between chlorhexidine gluconate (CHG) concentration on skin and resistant bacterial bioburden. CHG was almost always detected on the skin, and detection of methicillin-resistant Staphylococcus aureus, carbapenem-resistant Enterobacteriaceae, and vancomycin-resistant Enterococcus on skin sites was infrequent. However, we found no correlation between CHG concentration and bacterial bioburden.

Type
Concise Communication
Copyright
© 2019 by The Society for Healthcare Epidemiology of America. All rights reserved. 

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References

Swan, JT, Ashton, CM, Bui, LN, et al. Effect of chlorhexidine bathing every other day on prevention of hospital-acquired infections in the surgical ICU: a single-center, randomized controlled trial. Crit Care Med 2016;44:18221832.CrossRefGoogle ScholarPubMed
Donskey, CJ, Deshpande, A. Effect of chlorhexidine bathing in preventing infections and reducing skin burden and environmental contamination: a review of the literature. Am J Infect Control 2016; 44:1721.CrossRefGoogle ScholarPubMed
Vernon, MO, Hayden, MK, Trick, WE, Hayes, RA, Blom, DW, Weinstein, MD. Chlorhexidine gluconate to cleanse patients in a medical intensive care unit: the effectiveness of source control to reduce the bioburden of vancomycin-resistant Enterococci. Arch Intern Med 2006;166:306312.CrossRefGoogle Scholar
Milstone, A, Passaretti, C, Perl, T. Chlorhexidine: expanding the armamentarium for infection control and prevention. Clin Infect Dis 2008;46:274281.Google ScholarPubMed
Weinstein, RA. Intensive care unit environments and the fecal patina: a simple problem? Crit Care Med 2012;40:13331334.CrossRefGoogle ScholarPubMed
Popovich, KJ, Lyles, R, Hayes, R, et al. Relationship between chlorhexidine gluconate skin concentration and microbial density on the skin of critically ill patients bathed daily with chlorhexidine gluconate. Infect Control Hosp Epidemiol 2012;33:889896.CrossRefGoogle ScholarPubMed
Supple, L, Kumaraswami, M, Kundrapu, S, et al. Chlorhexidine only works if applied correctly: use of a simple colorimetric assay to provide monitoring and feedback on effectiveness of chlorhexidine application. Infect Control Hosp Epidemiol 2015;36:10951097.CrossRefGoogle ScholarPubMed
Alserehi, H, Filippell, M, Emerick, M, et al. Chlorhexidine gluconate bathing practices and skin concentrations in intensive care unit patients. Am J Infect Control 2018;46:226228.CrossRefGoogle ScholarPubMed
O’Horo, JC, Silva, GLM, Munoz-Price, LS, Safdar, N. The efficacy of daily bathing with chlorhexidine for reducing healthcare-associated bloodstream infections: a meta-analysis. Infect Control Hosp Epidemiol 2012;33:257267.CrossRefGoogle ScholarPubMed
Edmiston, CE, Krepel, CJ, Seabrook, GR, Lewis, BD, Brown, KR, Towne, JB. Preoperative shower revisited: can high topical antiseptic levels be achieved on the skin surface before surgical admission? J Am Coll Surg 2008;207:233239.CrossRefGoogle ScholarPubMed