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XXY Mice

Published online by Cambridge University Press:  14 April 2009

Bruce M. Cattanach
Bruce M. Cattanach
Affiliation:
Medical Research Council Induced Mutagenesis Group, Institute of Animal Genetics, Edinburgh, 9

Extract

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Welshons & Russell (1959) have presented data to show that the XO chromosomal constitution in the mouse is female. This conclusion was based on results of genetical tests with sex-linked markers and on chromosome counts. All XO females were matroclinous, that is, they had inherited their X-chromosome from their mother. Females of this type will arise when non-disjunction occurs in the meiotic divisions of the father and results in spermatozoa without a sex-chromosome. Alternatively, the paternal sex-chromosome may be lost from the fertilized ovum if non-disjunction of sister-chromatids occurs during the first cleavage division. This latter explanation has been urged by Ohno, Kaplan & Kinosita (1959), who found no evidence for non-disjunction of the X-and Y-chromosome in an extensive cytolosical examination of the mouse testis.

Type
Short Notes
Information
Genetics Research , Volume 2 , Issue 1 , February 1961 , pp. 156 - 158
Copyright
Copyright © Cambridge University Press 1961

References

REFERENCES

Falconer, D. S. (1953). Total sex-linkage in the house mouse. Z. indukt. Abstam.- u. Vererb Lehre, 85, 210–219.Google ScholarPubMed
Fechheimer, N. S. (1960). Mammalian cell chromosome counts: A simple method for making preparations. Nature, Lond., 188, 247–248.CrossRefGoogle Scholar
Ford, C. E. & Hamerton, J. L. (1956). A colchicine, hypotonic citrate, squash sequence for mammalian chromosomes. Stain Tech. 31, 247–251.CrossRefGoogle ScholarPubMed
Ford, C. E., Jones, K. W., Miller, O. J., Mittwoch, U., Penrose, L. S., Ridler, M. & Shapiro, A. (1959). The chromosomes in a patient showing both mongolism and the Klinefelter syndrome. Lancet, i, 709–710.CrossRefGoogle Scholar
Jacobs, P. A. & Strong, J. A. (1959). A case of human intersexuality having a possible XXY sex-determining mechanism. Nature, Lond., 183, 302–303.CrossRefGoogle ScholarPubMed
McLaren, A. (1960). Unbalanced sex-chromosome constitutions. Genet. Res. 1, 253–261.CrossRefGoogle Scholar
Ohno, S., Kaplan, W. D. & Kinosita, R. (1959). Do XY- and O- sperm occur in Mus musculus? Proc. nat. Acad. Sci., Wash., 45, 554–560.Google Scholar
Russell, L. B. & Bangham, J. W. (1960). Further analysis of variegated-type position effects from X-autosome translocations in the mouse. Genetics, 45, 1008–1009.Google Scholar
Welshons, W. J. & Russell, L. B. (1959). The Y-chromosome as the bearer of male determining factors in the mouse. Proc. Nat. Acad. Sci. 45, 560–566.CrossRefGoogle ScholarPubMed