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Variation in the shape of the mouse mandible: 1. Effect of age and sex on the results obtained from the discriminant functions used for genetic monitoring

Published online by Cambridge University Press:  14 April 2009

D. P. Lovell ,
P. Totman  and
F. M. Johnson
D. P. Lovell
Affiliation:
MRC Experimental Embryology and Teratology Unit, Woodmansterne Road, Carshalton, Surrey SM5 4EF, England
P. Totman
Affiliation:
MRC Experimental Embryology and Teratology Unit, Woodmansterne Road, Carshalton, Surrey SM5 4EF, England
F. M. Johnson
Affiliation:
Laboratory of Genetics, National Institute of Environmental Health Sciences, Research Triangle Park, NC 27709, USA
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The shape of the mandible of the mouse can be described by a series of discriminant functions which have been used to discriminate between and investigate relationships among strains of mice. The effect of sex and variation in age of the animal on the results obtained from these functions has been investigated. Significant sex differences in mandible shape were detected, but these were considerably smaller than the differences found between two inbred strains. A simple correction for expressing each measure as a proportion of the sum of the measures on each bone removes the effects of overall size. Significant age effects were found, but these were only large in animals under seven weeks of age where considerable changes are taking place in the relative lengths of bone measurements. Routine testing for genetic authenticity using the shape of the mandible is possible over a wide age range and may be an efficient method for monitoring genotypes at the end of long-term experiments.

Type
Research Article
Information
Genetics Research , Volume 43 , Issue 1 , February 1984 , pp. 65 - 73
Copyright
Copyright © Cambridge University Press 1984

References

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