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Unusual genetic architecture of natural variation affecting drug resistance in Drosophila melanogaster

Published online by Cambridge University Press:  17 February 2003

ROLAND CARRILLO  and
GREG GIBSON
ROLAND CARRILLO
Affiliation:
Department of Genetics, Gardner Hall, North Carolina State University, Raleigh, NC 27695-7614, USA
GREG GIBSON
Affiliation:
Department of Genetics, Gardner Hall, North Carolina State University, Raleigh, NC 27695-7614, USA

Abstract

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Naturally occurring genetic variation was quantified for survival time of adult Drosophila melanogaster exposed to chronic ingestion of the drugs nicotine, caffeine, dopamine, tyramine and octopamine. Responses to nicotine, tyramine and octopamine were genetically correlated in both sexes, whereas caffeine response correlated with starvation resistance. However, there is also genetic variation that is specific for each of the drugs. Females tended to be more resistant than males to nicotine and caffeine but sex-by-genotype interactions were also seen for these drugs and for the response to dopamine. An unusual and complex genetic architecture was observed in crosses between lines with different responses to caffeine ingestion. Additive and dominance components were clearly seen from the analysis of F1 individuals, but increased female resistance to caffeine in backcross generations and increased male sensitivity in F2 generations confused the interpretation of possible epistatic contributions.

Type
Research Article
Information
Genetics Research , Volume 80 , Issue 3 , December 2002 , pp. 205 - 213
Copyright
© 2002 Cambridge University Press