Hostname: page-component-848d4c4894-4hhp2 Total loading time: 0 Render date: 2024-05-29T08:40:12.606Z Has data issue: false hasContentIssue false

Triplications and the problem of non-homologous crossing-over

Published online by Cambridge University Press:  14 April 2009

H. Slizynska
Affiliation:
Institute of Animal Genetics, Edinburgh, 9

Extract

Core share and HTML view are not available for this content. However, as you have access to this content, a full PDF is available via the ‘Save PDF’ action button.

Two triplications induced in a normal halpoid chromosome complement by TEM (Tr-I) and by mustard gas (Tr-II) are described. Two models which may lead by successive steps to the formation of a triplication are suggested. The induction of two latent breaks is essential in both of them. The origin of repeats in general is discussed. It is concluded that chromosome breaks rather than non-homologous crossing-over constitute the major source of repeats.

Type
Research Article
Copyright
Copyright © Cambridge University Press 1968

References

REFERENCES

Auerbach, C. (1949). Chemical induction of mutations (8th Int. Conf. Genet.). Hereditas, Suppl. 128.Google Scholar
Auerbach, C. (1951). Problems in chemical mutagenesis. Cold Spr. Harb. Symp. quant. Biol. 16, 199.CrossRefGoogle ScholarPubMed
Auerbach, C. & Moser, H. (1953). Analysis of mutagenic action of formaldehyde food. II. The mutagenic potentialities of the treatment. Z. indukt. Abstamm. -u. VererbLehre 85, 547563.Google ScholarPubMed
Bridges, C. B. (1919). Duplications. (Abstracts.) Anat. Rec. 15, 357358.Google Scholar
Gans, M. (1953). Etude génétique et physiologique du mutant z de Drosophila melanogaster. Bull. biol. Fr. Belg. (Suppl.), 38, 119.Google Scholar
Green, M. M. (1959). Non-homologous pairing and crossing over in Drosophila melanogaster. Genetics 44, 12431256.CrossRefGoogle ScholarPubMed
Green, M. M. (1961). Further data on non-homologous pairing and crossing over in Drosophila melanogaster. Genetics 46, 15551560.CrossRefGoogle ScholarPubMed
Grell, R. F. (1964). Chromosome pairing, crossing over, and segregation in Drosophila melanogaster. Symposium on genes and chromosomes. Buenos Aires, Argentina.Google Scholar
Kaplan, W. D. (1953). The influence of Minutes upon somatic crossing over in Drosophila melanogaster. Genetics 38, 630651.CrossRefGoogle ScholarPubMed
Levitan, M. (1962). Spontaneous chromosome aberrations in Drosophila robusta. Proc. natn. Acad. Sci. U.S.A. 48, 930937.CrossRefGoogle ScholarPubMed
Lewis, E. B. (1967). Genes and gene complexes. In Heritage from Mendel, ed. Brink, R. A.. University of Wisconsin Press.Google Scholar
Muller, H. J. (1935). The organization of chromatin deficiencies as minute deletions subject to insertion elsewhere. Genetica 17, 237252.CrossRefGoogle Scholar
Nichols, W. W., Levan, A., Aula, P. & Norby, E. (1964). Extreme chromosome breakage induced by measles virus in different in vitro systems. Hereditas 51, 380382.CrossRefGoogle Scholar
Peterson, H. M. & Laughnan, J. R. (1963). Intrachromosomal exchange at the Bar locus in Drosophila. Proc. natn. Acad. Sci., U.S.A. 50, 127133.CrossRefGoogle ScholarPubMed
Slizynska, H. (1957). Cytological analysis of formaldehyde induced chromosomal changes in Drosophila melanogaster. Proc. R. Soc. Edinb. 66, 288304.Google Scholar
Slizynska, H. (1963 a). Origin of repeats in Drosophila chromosomes. Genet. Res., Camb. 4, 154157.CrossRefGoogle Scholar
Slizynska, H. (1963 b). Mutagenic effects of X-rays and formaldehyde food in spermatogenesis of Drosophila melanogaster. Genet. Res., Camb. 4, 248257.CrossRefGoogle Scholar
Slizynski, B. M. (1964). Chiasmata in spermatocytes of Drosophila melanogaster. Genet. Res., Camb. 5, 8084.CrossRefGoogle Scholar
Smithies, O., Connel, G. E. & Dixon, G. H. (1962). Chromosomal rearrangements and the evolution of haptoglobin genes. Nature, Land. 196, 232236.CrossRefGoogle ScholarPubMed
Snyder, L. A. (1963). Evidence of an essential difference between point mutations and chromosome breaks induced by triethylene melamine in Drosophila spermatozoa. Z. VererbLehre 94, 182189.Google ScholarPubMed
Sonbati, E. M. & Auerbach, C. (1960). The brood pattern for intragenic and intergenic changes after mustard gas treatment of Drosophila ♂♂ Z. VerebLehre 91, 523528.Google Scholar
Stern, C. (1936). Somatic crossing over and segregation in D. melanogaster. Genetics 21, 625730.CrossRefGoogle Scholar