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Time until fixation of a mutant belonging to a multigene family

Published online by Cambridge University Press:  14 April 2009

Tomoko Ohta
Tomoko Ohta
Affiliation:
National Institute of Genetics, Mishima 411, Japan

Summary

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Time until fixation of a mutant that occurs in one copy of a multigene family was investigated from the standpoint of population genetics. Because of the complexity of the double process of random drift (on the chromosome and in the population), an approximate method based on the rate of steady decay of genetic variability is applied. The simple model of gene conversion with constant gene family size is also used. The expectation based on the approximate method is shown to be valid by extensive Monte Carlo simulations, and the results are useful for understanding the mechanisms of turnover of multigene families, when comparison is available between closely related species.

Type
Research Article
Information
Genetics Research , Volume 41 , Issue 1 , February 1983 , pp. 47 - 55
Copyright
Copyright © Cambridge University Press 1983

References

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