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The susceptibility to cortisone-induced cleft palate of recombinant inbred strains of mice: lack of association with the H-2 haplotype

Published online by Cambridge University Press:  14 April 2009

M. Vekemans ,
B. A. Taylor  and
F. C. Fraser
M. Vekemans
Affiliation:
Department of Biology, McGill University, 1205 avenue Docteur Penfield, Montreal, Quebec H3A 1B1, Canada
B. A. Taylor
Affiliation:
Department of Biology, McGill University, 1205 avenue Docteur Penfield, Montreal, Quebec H3A 1B1, Canada
F. C. Fraser
Affiliation:
The Jackson Laboratory, Bar Harbor, Maine 04609, U.S.A.

Summary

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Recombinant-inbred (RI) strains of mice derived from the cross of strains C57BL/6J and DBA/2J were used to study the inheritance of susceptibility to cortisone-induced cleft palate. Most of the RI strains could be classified as either resistant, like C57BL/6J, or susceptible, like DBA/2J, suggesting the segregation of a major locus. An association with the phosphoglucomutase-1 locus (Pgm-1) on Chromosome 5 was observed. There was no association with the H-2 locus on Chromosome 17 as had been reported in previous studies utilizing different strains. We conclude that susceptibility to cortisone-induced cleft palate may be determined by different loci depending on the strains studied.

Type
Short Paper
Information
Genetics Research , Volume 38 , Issue 3 , December 1981 , pp. 327 - 331
Copyright
Copyright © Cambridge University Press 1981

References

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